Sentences with phrase «metastatic tumor sites»

The unique tumor - tropic properties of neural stem cells (NSCs) may provide the means to significantly improve antibody distribution within metastatic tumor sites throughout the body [2], [3], [4], [5], [6].

Intravenously - delivered NSCs preferentially migrate to primary and metastatic tumor sites within and outside the CNS.

Not exact matches

Plasma samples also can not address the issue of expression heterogeneity (primary tumor vs. metastatic site (s)-RRB-.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

The team chose to compare breast tissue from healthy individuals with tumor samples taken from breast cancer patients — including both primary tumors that had not spread from the breast to other body sites, and highly aggressive, metastatic tumors.

In some individuals there were significant genetic differences between tumor sites, suggesting early metastatic spread; in others, there was little difference between a primary tumor and its metastases.

It is not easy to determine whether metastasis began early or late in the development of the primary tumor or whether individual metastatic sites were seeded directly from the original tumor or from an intermediate site.

«Given the high discrepancy of genetic findings between a primary tumor and metastatic sites within the same patient, our study suggests we should concentrate on metastatic sites that represent the majority of the tumor burden.

The prognosis for metastatic cancer (also called stage IV cancer) is generally poor, so a technique that could detect these circulating tumor cells before they have a chance to form new colonies of tumors at distant sites could greatly increase a patient's survival odds.

However, metastatic tumors continued to appear over time in untreated sites likely because those tumors were so small at initial treatment that they were not detected.

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

hen breast cancer patients get chemotherapy before surgery to remove their tumor, it can make remaining malignant cells spread to distant sites, resulting in incurable metastatic cancer, scientists reported last week.

The degree of heterogeneity did not differ between primary and metastatic sites, indicating that more than one core biopsy, or even an entire tumor block might be needed to determine PD - L1 expression in a tumor.

Tissue heterogeneity in PD - L1 expression in both primary and metastatic sites indicates that a single core biopsy might not be sufficient to determine tumor PD - L1 expression.

One limitation of our study is the use of metastatic samples from various organ sites, potentially influencing expression via differences from the organ - specific tumor microenvironment.

While metastatic sites may have originated from the primary tumor, several studies have demonstrated a different immunohistochemical or mutation profile compared to the primary.

currently the tumor treatment studies are restricted to primary tumors but very little is being done to understand nanoparticle routing and penetration of metastatic site

[25] Seeing that in metastatic patients the only available tumor is often core biopsies rather than whole tissue blocks, we next attempted to determine whether the degree of heterogeneity varies between primary and metastatic sites, using the TMA cores as surrogates for core biopsy specimens.

Within a given tumor, variable PD - L1 staining heterogeneity was seen, however the degree of heterogeneity was similar in primary and metastatic sites (P = 0.482).

Additionally there is only weak correlation in staining between the matched primary and distant metastasis, suggesting that the primary tumor is not an adequate surrogate for determining PD - L1 expression in metastatic sites.

There was no difference in lactate dehydrogenase, the number of metastatic sites, prior adjuvant therapy, primary in place at initiation of therapy, or intent of treatment across the cohorts for right - compared with left - sided tumors.

MCG / AU Health was the only site for the phase 1 trial to test the vaccine's safety and look at tumor response in patients with persistent, recurrent and / or metastatic disease.

Metastatic disease refers to cancer that has spread through the blood or lymph system to form new tumors in other parts of the body distinct from the original site.

December 13, 2011 Molecular markers can predict spread of cancer, guide treatment Molecular markers found in cancer cells that have spread from a primary tumor to a limited number of distant sites can help physicians predict which patients with metastatic cancer will benefit from aggressive, targeted radiation therapy.

This is supported by recently published data in the New England Journal of Medicine (21), where patients with triple - negative breast cancer were seen to show increased complete pathologic response to bevacizumab treatment, with no detectable tumor at primary or metastatic sites, whereas no improvement was observed in hormone receptor — positive cases.

The tumors are very aggressive and metastatic, so it is a fair assumption that at the time of diagnosis the disease will have already spread beyond the primary site.

We believe that disrupting this niche will delay or prevent metastatic spread, and more importantly, protect tumor sites from hemorrhage, which is the most common lethal event in this disease.

Hematogenous metastatic brain tumors commonly originate from extracranial sites.