Sentences with phrase «metastatic tumors in the brain»

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Tumors that originate in other organs of the body and spread to the brain are known as metastatic brain tTumors that originate in other organs of the body and spread to the brain are known as metastatic brain tumorstumors.

Published in the February 27 issue of Cell, the study found that tumor cells that reach the brain — and successfully grow into new tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic invasion.

Dr. Massagué is particularly interested in the ability of tumor cells to hug blood vessels, as he suspects this behavior may be essential for the survival of metastatic cancer cells not only in the brain but also in other parts of the body where metastatic tumor growth can occur.

The MRI imaging detected metastatic tumors, including micrometastases, in lung, liver, lymph node, adrenal gland, bone, and brains of the mice.

Similar to high - grade gliomas, which originate in the brain, these metastatic brain tumors are lethal, and there are very few therapeutic options.

In early clinical trials, Sessler and his colleagues treated 39 metastatic brain tumor patients with texaphyrins 2 hours before radiation therapy for 10 days.

CSCs were prepared from 231BrM and CN34BrM cells that were infected with lentivirus carrying with or without miR -7-2, and they were transplanted into nude mice through intracardiac injection followed by monitoring metastatic tumor growth in the brain.

We also examined the expression of miR - 7 and KLF4 in brain - metastatic lesions and found that these genes were significantly down - or upregulated, respectively, in the tumor cells in brain.

After 5 weeks, metastatic tumor growth in the brain was prominent in all mice that received CSCs carrying vector only.

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

Furthermore, we examined the expression of KLF4 in brain metastatic tissues by immunohistochemistry and found that KLF4 was expressed more in the nucleus and significantly less in cytosol in brain metastatic tissues compared with primary tumors (Fig. 6C and D).

They found that injecting into the carotid artery breast cancer cells that express markers allowing them to enter the brain — cells labelled with bioluminescent and fluorescent markers to enable tracking by imaging technologies — resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced breast cancer patients.

To further validate the clinical significance of miR - 7 and KLF4 in brain metastasis of breast cancer, we microdissected tumor tissues from both primary and brain metastatic lesions followed by conducting TaqMan qRT - PCR.

They found that injecting patient - derived, brain - seeking melanoma cells into the carotid artery of these preclinical models resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced melanoma cancer patients.

We found that the expression of miR - 7 was significantly lower in brain metastatic tumors than that in primary tumor tissues (Fig. 6A, left), whereas the expression of KLF4 was significantly higher in brain metastatic tissue compared with primary tumors (Fig. 6A, right).

«Metastatic brain tumors — often from lung, breast or skin cancers — are the most commonly observed tumors within the brain and account for about 30 percent of advanced breast cancer metastases,» says Khalid Shah, MS, PhD, director of the Molecular Neurotherapy and Imaging Laboratory in the MGH Departments of Radiology and Neurology, who led the study.

Generally, treatment of metastatic brain tumors will include surgery, stereotactic radiosurgery, conventional radiation therapy and chemotherapy, each used independently or in combination.

I then transitioned to a dedicated surgical neuro - oncology fellowship at the University of Miami, where I gained significant experience in treating malignant brain tumors, developing clinical trials, and delivering minimally invasive therapies for both primary and metastatic tumors of the central nervous system.

The Program specializes in the treatment of primary head and neck cancers, brain and spine tumors such as squamous cell carcinoma, basal cell cancer, glomus tumor, paragangliomas, acoustic neuromas, salivary gland and mucosal tumors, astrocytomas, oligodendrogliomas, glioblastomas, and hemangioblastomas, and metastatic tumors that may have arisen from elsewhere in the body such as the breast, lung, or prostate.

Brain Tumors Tumors in the brain may occur in dogs as primary or as metastatic tuBrain Tumors Tumors in the brain may occur in dogs as primary or as metastatic tTumors Tumors in the brain may occur in dogs as primary or as metastatic tTumors in the brain may occur in dogs as primary or as metastatic tubrain may occur in dogs as primary or as metastatic tumorstumors.

Secondary or metastatic brain tumors originate from malignant tumors (cancers) located primarily in other organs and metastasize (spread) to the brain.