Developmental expression of transcription factor genes in a demosponge: insights into the origin of
metazoan multicellularity.
The A. queenslandica genome allows us to assess systematically the origin of the six hallmarks of
metazoan multicellularity: (1) regulated cell cycling and growth; (2) programmed cell death; (3) cell — cell and cell — matrix adhesion; (4) developmental signalling and gene regulation; (5) allorecognition and innate immunity; and (6) specialization of cell types.
These cardinal features of
metazoan multicellularity have their origins on the metazoan stem and often are the result of metazoan gene novelties combining with more ancient factors.