Sentences with phrase «methoxymethyl moiety»

«This makes the uranyl moiety very important, but also the universal view that the ITI was a niche concept of limited applicability dominated because it was restricted to high oxidation state actinide metals like uranium.

The versatility of HPLC in compound separation is due mainly to the availability of numerous chromatographic matrices (reversed - phase, normal phase, ion - exchange, ion - pair, and others), its reproducibility (peak performance and results), and its selectivity (compounds of specific moieties / structures).

«This molecular switching technology of an aromatic compound using an orthoquinone moiety is a new insight that appears to have been reported first by our research team.»

Upon irradiation with ultraviolet (UV) light before deposition on graphene, the diazirine moiety is cleaved and a reactive carbene species is formed.

The P2 4 - aminomethylphenylalanine moiety of the inhibitor forms a salt - bridge with the nonconserved Asp83 of NS2B; ion - pairing between Asp83 and the P2 residue of the substrate likely accounts for the enzyme's high catalytic efficiency.

The carbohydrate moiety associated with this residue, which is recognizable in the cryo - EM electron density, may function as an attachment site of the virus to host cells.

«We could introduce different functional organic moieties to the present MOF and create materials with magnetic, electronic and photonic functionalities.»

The substrate specificity of mammalian thioglycosidase involves both the aglycone and the glycosyl moieties.

In addition, exosomes are being co-opted as a treatment modality and have been modified through their parental cells to express a targeting moiety or marker tag on their surface.

Some compounds containing the triarylmethane moiety are known to exhibit anticancer properties, and many new compounds have been synthesized to investigate their bioactivities.

«In conclusion, we demonstrated how sub-natural line width vibrational resolved RIXS gives direct experimental access to the ground state potential energy surface around selected atomic sites and moieties, not accessible with other techniques.

When the transcript of the M1 RNA gene is combined with the protein moiety not only is a tRNA precursor cleaved but also the precursor to 4.5 S RNA from Escherichia coli.

Ins - PBA - F consists of a long - acting insulin derivative that has a chemical moiety, phenylboronic acid (PBA), added to one end.

The isoselenocynate moiety was designed based on naturally occurring isothiocyanates, which can be found in vegetables, such as broccoli and cauliflower, and are known for their cancer prevention properties.

Furthermore, by using a digestive enzyme specific for cutting the arabinogalactan sugar chain at various sections, the group was able to identify that a disaccharide moiety containing a methyl - glucuronic acid unit located at the terminus of arabinogalactan, was essential for AMOR's activity.

The organic chemists in the group then synthesized the disaccharide moiety on the terminus of arabinogalactan.

The optimal spacer length between the benzimidazole N - 1 and the basic nitrogen is a 3 - carbon propylene moiety (e.g. 49), while shorter (2 carbon) or longer (4 - 5 carbon) linkers result in 5 to 10-fold lower anti-HIV activity.

As expected, such studies confirmed that three functional groups on the indole moiety properly overlapped the three pharmacophore residues of the parent compound.

Starting from compound 16, several derivatives, in which the D - Phe (4 - F) 1 moiety was replaced by various aromatic amino acids, while maintaining the same configuration of [D - Phe (4 - F) 1, L - Arg2] fragment, have been synthesized.

The introduction of a 2,3 - disubstituted pyridine ring with an aminomethyl moiety at the 2 - position led to compound 142 with an IC50 value of 0.021 μM that showed a comparable potency to 131.

Since it is plausible that the unfavorable pharmacokinetic profile of 182a is due to a rapid oxidative metabolism, a series of derivatives functionalized with electron deficient moieties on the terminal aromatic ring were synthesized.

Among the plethora of organic and inorganic chemical consolidants for gypsum that have been tested in our laboratory, many of them possess chemical moieties that are capable of interacting with surface calcium ions.

Finally, the replacement of the pyridine ring with a pyrazine moiety (compound 164) conferred an antiviral potency comparable to that of the benzyl analogue 157.

The CRISPR — Cas9 RNA - guided endonuclease system allows precise and efficient modification of complex genomes and is continuously developed to enhance specificity, alter targeting and add new functional moieties.

The introduction of an aminomethyl moiety led to the active compound 135 with an IC50 value of 2 nM.

In order to explore new pharmacophore moieties, FC131 was used as a lead compound for the development of novel CXCR4 antagonists.

N - Acylethanolamines are fatty acid derivatives that are amide - linked to an ethanolamine moiety.

In order to identify novel non-peptide CXCR4 ligands, the introduction of crucial functional moieties for receptor binding onto a bicyclic heterocyclic scaffold to mimic FC131's quite rigid backbone was carried out.

In particular, an oligomer based on a biguanide moiety, NB325, showed wide antiviral activity in several in vitro assays.

The replacement of the Arg3 - Nal4 peptide bond with an (E)- alkene isostere in compound 7 produced a negative effect on CXCR4 inhibitory activity, probably due to the lack of H - bonding of amide moiety and a different interaction of pseudo -1,3-allylic strain between the Arg3 carbonyl group and the Nal4 side chain.

CXCR4 antagonists in which a substituted benzylic aminomethyl group or a heterocyclic aminomethyl moiety replacing the butyl amine residue showed potent antiviral activity [88].

Tyrosine is an amino acid present in proteins that contains a hydroxyl moiety, and kinases are enzymes that catalyze phosphorylation (addition of a phosphate group) of various substrates in the cell.

Major challenges in the development of drug delivery systems (DDSs) have been the short half - life... chemistry affects the PK profile and organ distribution of a gold nanoparticle - based DDS containing both a passive and active targeting moiety via... -LSB-...]

The targeted drug delivery appears to be a very promising strategy for controlling the biodistribution of the cytotoxic agent only on malignant tissues by linking it to tumor - targeting moiety.

Significance of the carbohydrate moiety of the rat ovarian luteinizing - hormone / chorionic - gonadotropin receptor for ligand - binding specificity and signal transduction

The researchers determined that iminopyrimidinones could bind in the same manner as the isothiourea moiety.

X-ray crystallography revealed that the isothiourea moiety was making an extended network of hydrogen bonds with functional groups that were key to BACE1's catalytic activity.

In contrast to previously reported CD123 - targeted agents, such as CSL360 / 362, MGD006, and SGN - CD123A, 12,13,32,33 which employ variable domains of the 7G3 antibody and bind to the N - terminal domain of CD123, 31 IMGN632 binds to the D2 - D3 region in the extracellular domain via its unique G4723A antibody moiety.

The effects that we and others had observed with the old GcMAF and old Goleic were not due to the moiety of the protein molecules, but to the moiety of the glycosaminoglycans, the vitamin nutrients, and the oleic acid.

This is made by binding creatine to to parts of hydrochloride molecules (technically, the creatine molecule is bound to a hydrochloride «moiety.»)

The phosphatases, in turn, contain a redox - sensitive cysteine moiety in their catalytic site, which is converted by H2O2 into a sulfenic acid moiety, which renders the phosphatase inactive.

Even the receptors to which pain - modulating neurotransmitters (endorphin, serotonin, and GABA) attach are protein moieties.

On digestion, sucrose is hydrolyzed in the gut into its 2 equal molecular moieties of glucose and fructose.

The presence of a glucose moiety compared with a galactose or arabinose on the cyanidin and peonidin anthocyanidins present in cranberry juice seems to make them more bioavailable as a percentage of the delivered dose (16).

These boys soaked up everything about Aboriginal culture; the moiety system, songlines, language, dance and history.

In the case of a failure of the surface to warm due to a La Nina - like process, the OLR reduction (and hence the energy gain) will be lessened by the reduction in water vapor and other feedback moieties, but it will still be greater than occurs with a warmed surface.

Imagine that its only radiatively active moiety is CO2 — no ozone, no water to speak of, etc. — so that its temperature is determined by the balance between absorption of incoming infrared by CO2 and emission of infrared out of the layer by CO2.

That argument fails also, as long as we make assumption # 3 above, that UP temperatures are determined by CO2 and other moieties that will act in the same direction.

This diverted moiety of power was carried by Bode's feedback circuit β.

In June 2002, the Yirritja moiety clans57 and the Dhuwa moiety clans58 (of the Yolgnu people) lodged a claim seeking clarification of the rights provided under the ALRA, and a determination of their native title rights and interests over the area.