Sentences with phrase «mevalonate pathway»

Poggi A, Boero S, Musso A, Zocchi MR. Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human natural killer cells.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

The study, «P53 - and mevalonate pathway - driven malignancies require Arf6 for metastasis and drug resistance» by Ari Hashimoto and colleagues, has been published online ahead of print and suggests that statin - like drugs may be effective treatments for breast cancer patients whose tumors express high levels of Arf6 signaling proteins.

Thanks to the activity of the mevalonate pathway, Rab11b delivers Arf6 (green) to the plasma membrane, where it can be activated to promote cancer cell invasion and drug resistance.

The mevalonate pathway (MVP) is a metabolic pathway that produces the building blocks for a wide range of biological molecules, from cholesterol to the long - chain lipid groups that anchor certain proteins to cell membranes.

Statin Drugs lower cholesterol by inhibiting the enzyme HMG - CoA reductase, which is the rate - limiting enzyme of the mevalonate pathway of cholesterol synthesis.

Statin drugs for lowering cholesterol block the mevalonate pathway which is the same pathway used by cells to make cholesterol as well as used by cells for growth and division.

While vitamin C does lower cholesterol levels somewhat it does not block the mevalonate pathway nor causes cancer.