Sentences with phrase «mice and human patients»

After confirming in mouse models that cells from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast cancers from both mice and human patients.

This is the finding of a study in both mice and human patients led by researchers at NYU Langone Medical Center and published online June 9 in the journal Cell.

Not exact matches

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

In the brain, his FFI mice develop neuronal loss in the thalamus and his CJD mice experience spongiosis in the hippocampus and the cerebellum, reflecting the damage seen in the brains of human patients.

It works in cell studies and in mouse studies, but so far has proved frustratingly ineffective in human patients.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

Many PD patients typically show an increase in anxiety and depression, and in this respect the SNCA mouse model did not replicate the human condition.

Researchers have isolated exosomes from tumors and from blood of patients with breast cancer, and from blood of mice with human tumors grown after breast implantation in mice, called ortoxenogratfs.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

The authors said that this result suggests that the reason bacterial numbers are so high in these mice, and, by extension, human LAD patients, is not because of a defect in the immune system's surveillance mechanism but because of the inflammation caused by the immune system's abnormal response to normal levels of bacteria in the gums.

By assessing the survival of the cells that engulf the particles and measuring the levels of red or green light that they emitted, the researchers determined which formulation of particles performed best, then tested that formulation in mice with human brain cancer derived from their patients.

They waited until mice had had an EAE attack, akin to a flare - up of MS in human patients, and then administered Del - 1.

They created inflammation in the temporomandibular joints of the mice, and then measured bite force exerted by the mice to assess jaw inflammation and pain, similar to how TMJD pain is gauged in human patients.

«These results are especially exciting because they show that we can take findings in the mouse and possibly apply them at the human patient population,» said Koenig.

Just as the technique restored kidney, muscle, and insulin - producing function in the mouse models, he sees a future for rejuvenating neuronal populations, maybe even one day in human patients.

Hair thinning in a human patient and mouse with inherited loss of function mutations in WNT10A is shown.

«Our studies took us back and forth between human patients and our mouse model,» said Millar.

The researchers are now testing this approach in mice, and they envision that eventually the technology could be adapted to deliver the CRISPR components to treat infections or remove other unwanted bacteria in human patients.

BMT was effective in mice, but in humans resulted in death before the new bone marrow grew and expanded (called engraftment) in treated patients.

The goal of the study was to explore whether fecal microbiota from human IBS patients with diarrhea has the ability to influence gut and brain function in recipient mice.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse models of human cancers.

Though the findings were made in mice, not humans, the researchers say the crucial role of calcium may help explain another mystery: Why some hospital patients and nursing home residents have a much higher risk of contracting C. diff infections and the resulting diarrhea that carries its spores out of the body.

Tests in mice and nonhuman primates had shown TGN1412 to be safe, but when it was injected into humans — in a dose less than 1/500 of what was given to monkeys — it caused a massive release of infection - fighting T cells that overstimulated the patients» immune systems, resulting in multiple organ failure.

The cells exhibited many functions associated with tumor progression; their presence within mouse tumors substantially accelerated cancer growth, and in human lung tumors, a SiglecFhigh neutrophil signature was associated with poor patient survival.

Extracts from the brains of FFI patients transmitted disease to transgenic mice expressing a chimeric human - mouse PrP gene about 200 days after inoculation and induced formation of the 19 - kilodalton PrPSc fragment, whereas extracts from the brains of familial and sporadic Creutzfeldt - Jakob disease patients produced the 21 - kilodalton PrPSc fragment in these mice.

Previous studies have shown the drug to be effective at spurring new bone growth in mice and in humans with osteoporosis, and a U-M research team believes that it may spur new growth in brittle bone disease patients as well.

Further testing found these mice had lower - than - expected growth hormone and insulin - like growth factor (IGF1) levels in the blood, potentially explaining the small stature and delayed development seen in human patients.

And while we successfully demonstrated that cardiolipin can improve the function of mitochondria in flies, mouse models and in human cells, we need to explore its effects in actual patients.&raqAnd while we successfully demonstrated that cardiolipin can improve the function of mitochondria in flies, mouse models and in human cells, we need to explore its effects in actual patients.&raqand in human cells, we need to explore its effects in actual patients.»

«More research is needed to evaluate the efficacy of this use of a cancer medication to alleviate risk of sudden cardiac death, but we are hopeful that what we observed in mice will translate effectively to humans, providing patients and clinicians with a new paradigm for treating this common and life - threatening illness,» Dudley said.

The researchers grafted breast or lung tumors in mice, allowed the tumors to grow to small size and removed these tumors surgically — essentially mimicking the situation in a human tumor patient in which the tumor is surgically removed as soon as possible after diagnosis.

The work highlights a previously unrecognized molecular pathway that contributes to the malfunction of insulin - producing pancreatic beta cells in T1D in human patients and in mice, and shows that a chemical intervention can help beta cells function properly and survive.

«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»

Findings made in animal models do not always translate to patients, but it appears that this important eye vessel functions very similarly in mice and humans.

As a next step, Guha, Avadhani and colleagues plan to extend this study to in vivo mouse models and will also investigate these mechanisms in tumor samples from human breast cancer patients.

The researchers studied tumour tissue from patients, cultivated human tumour cells and tumours in mouse models for neuroblastoma.

The mice show many of the symptoms that human patients do, and so they were an especially good candidate to test iPS cells» abilities, says stem cell researcher Rudolf Jaenisch of the Whitehead Institute for Biomedical Research and the Massachusetts Institute of Technology, both in Cambridge, who collaborated with Townes on the project.

North says his group has already generated a human chimeric form of MAG - 1 that is equally effective as mouse MAG - 1, and they are now generating a humanized form for use in patients.

For all panels, n = 53 mice per genotype, 28 patients with MCI - AD, and 89 human controls.

Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T cells and monitor in a dish both how those cells now fight the tumor and react to healthy human tissue.

In all analyses, n = 53 mice per genotype, 28 patients with MCI - AD, and 89 human controls.

In their new paper in Journal of Immunology, Mandy Ford, Craig Coopersmith and colleagues show that 2B4 levels are increased on certain types of T cells (CD4 + memory cells) in human sepsis patients and in a mouse model of sepsis called CLP (cecal ligation + puncture).

Despite overexpression of mRNA from the XpdTTD allele relative to the wt allele (Figure 1E), TFIIH protein levels were reduced by 50 % in primary mouse XpdTTD / TTD fibroblasts (Figure 4E and 4F), thereby mimicking the situation in human patients with TTD.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutations.3

And, while the genetically - modified mice were made somewhat better by deactivating the HD gene in their hypothalamus, this approach isn't useable in human HD patients because their HD genes don't contain the sequences needed to turn them off with virus used by Petersen and colleaguAnd, while the genetically - modified mice were made somewhat better by deactivating the HD gene in their hypothalamus, this approach isn't useable in human HD patients because their HD genes don't contain the sequences needed to turn them off with virus used by Petersen and colleaguand colleagues.

They then examined the effect of a chemical that inhibits SRF and found that glucose uptake rates increased in both mice and human cells — and that the effects were greater in cells from patients who were insulin resistant or had type 2 diabetes.

Fleming researchers, using a Spondyloarthritis (SpA) mouse model have found that Tnfr2 signaling is regulating polyarthritis and a newly identified heart valve stenosis, which is a common comorbidity of SpA in human patients.

A very large number of changes have been discovered in HD model mice and then subsequently observed in human HD patients, suggesting the mice are useful research tools, even if they don't really have Huntington's disease.