Sentences with phrase «mice and humans at»

When they analyzed microbes found in fecal samples collected from mice and humans at different times of day, they discovered rhythmic fluctuations in the abundance of microbes and their biological activities.

«This is the first systematic comparison of the mouse and human at the genomic level,» said Bing Ren, Ph.D., co-senior author on the Consortium's main Nature study and professor of cellular and molecular medicine at the University of California, San Diego.

Not exact matches

Genetics has revealed that related molecular timepieces are at work in fruit flies, mice and humans

Compared with mice with cells from healthy people as well as non-chimera mice, those whose brains had human schizophrenia cells were more afraid to explore a maze, more anxious, more antisocial, less able to feel pleasure (from sipping sugar water), worse at remembering, and more sleepless — all of which characterize people with schizophrenia, too.

A study by researchers at the University of Chicago Medicine shows that when mice that are genetically susceptible to developing inflammatory bowel disease (IBD) were given antibiotics during late pregnancy and the early nursing period, their offspring were more likely to develop an inflammatory condition of the colon that resembles human IBD.

«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.

Researchers at Weill Cornell Medical College recently identified a gene abnormality that is associated with anxiety - related behaviors; it makes humans and mice hypervigilant to cues that signal danger.

«Our research is the first to study Zika infection in a mouse model that transmits the virus in a way similar to humans,» explains Alysson R. Muotri, Ph.D., professor and director of the Stem Cell Program at UC San Diego and co-senior author of the study.

The mouse, dog and human genomes are of high quality whereas the three others are at different stages of analysis completion.»

The book looks at fish that live in subfreezing waters, ruminating monkeys, ridiculously poisonous newts, birds that see in the ultraviolet, mice that live on lava flows, cave fish, coelacanths, bush babies, humans, and some other marvels of evolution.

«Finding these similarities and studying the aspects of mouse biology that may reflect human biology, allows us to approach the study of human illnesses in a better way,» affirms Bing Ren, one of the principal authors from the ENCODE Consortium and a lecturer in molecular and cellular medicine at the University of California — San Diego.

Géléoc and colleagues at Boston Children's Hospital studied mice with a mutation in Ush1c, the same mutation that causes Usher type 1c in humans.

Molecular geneticist Cheng Chi Lee, developmental biologist Gregor Eichele, and their co-workers at the Baylor College of Medicine in Houston have isolated a gene in mice and humans that shares 44 % of the amino acid sequence of the period (per) gene of the fruit fly Drosophila melanogaster.

The large amounts of fat around the testes of obese mice, «could alter the environment and encourage epigenetic changes», says Teague, who presented the results at the 14th World Congress on Human Reproduction in Melbourne, Australia, this month.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of at least a third of all myeloma cases.

This is the finding of a study in both mice and human patients led by researchers at NYU Langone Medical Center and published online June 9 in the journal Cell.

«Even the timing of the emergence of symptoms in the mice — during young adulthood — parallels the onset of schizophrenia in humans,» said Joseph Gogos, PhD, a professor of physiology and neuroscience at CUMC, a principal investigator at the Zuckerman Institute and a lead author of the paper.

Using the new gene - editing enzyme CRISPR - Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the lab.

At a neuroscience meeting, two teams of researchers will report implanting human brain organoids into the brains of lab rats and mice, raising the prospect that the organized, functional human tissue could develop further within a rodent.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

Judy Anderson, a muscular dystrophy expert at the University of Manitoba in Winnipeg, Canada, adds that evidence for acetylcholine defects in human muscular dystrophy has been contradictory over the years, but if this preliminary finding holds up in mice and humans, it could pave the way for new drug targets.

«There's a lot of grumbling, both in the general public and the scientific community, about how often we cure diseases in mice that never translates when we try those cures in humans,» says Felipe Sierra, director of the Division of Aging Biology at the National Institute on Aging.

Mice without the leptin gene, called ob / ob, overeat, weigh in at three to four times normal, and develop symptoms similar to the obesity - related diabetes seen in humans.

Kristen Earle, Gabriel Billings, KC Huang and Justin Sonnenburg, of Stanford University's School of Medicine, Department of Microbiology and Immunology, took second place with this photo of a mouse colon colonized with human microbiota, seen at 63x.

Dr. Aplin and Jessica Teh, PhD, his senior postdoctoral researcher at Jefferson (Philadelphia University + Thomas Jefferson University), examined the effects of a combination of two FDA - approved targeted agents on human melanomas grafted onto mice.

Using the supercomputers at Almaden and Lawrence Livermore National Laboratory, the group simulated networks that crudely approximated the brains of mice, rats, cats and humans.

«For example, cancer research is heavily reliant on mouse models, and as a result we've become very good at curing mice, but that hasn't translated very well to humans.

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells.

However, if a softer noise (known as a prepulse) is played before the loud tone, mice and humans are «primed» and startle less at the second, louder noise.

Joseph Castellano at Stanford University in California and his colleagues discovered this by collecting blood from people at three different life stages — babies, young people around the age of 22, and older people around the age of 66 — and injecting the plasma component into mice that were the equivalent of around 50 years old in human years.

The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.

Working with human breast cancer cells and mice, scientists at The Johns Hopkins University say new experiments explain how certain cancer stem cells thrive in low oxygen conditions.

A common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD) in the offspring of obese mice, according to researchers at the University of Colorado Anschutz Medical Campus.

Before Katlyn showed up at NIH, the doctors there were already well prepared: They had inserted healthy human ADA genes into a modified mouse retrovirus — a type of virus that can enter human cells and transfer new genetic material right into the DNA strands in their nuclei.

They found evidence of Del - 1 in the same areas as osteoclast activity, then followed up by generating human and mouse osteoclasts in vitro and found Del - 1 mRNA and protein expressed at high levels.

MLVs so dependably cause cancer in lab - bred mice — especially leukemia and lymphoma — that a small fraternity of scientists at the NCI and elsewhere has fruitfully studied these viruses since the 1960s in an effort to understand how human cancer begins.

In marked contrast to the widely held notion that the insulin - producing pancreatic beta cell loses function with wear and tear, the researchers now show that mouse and human beta cells are fully functional at advanced age.

Starting in the mid-2000s, Yoshiki Sasai's team at the RIKEN Center for Developmental Biology in Kobe, Japan, demonstrated how to grow brainlike structures using embryonic stem cells, first from mice and then humans.

Now, a new study in mice shows how a gene, called FOXP2, implicated in a language disorder may have changed between humans and chimps to make learning to speak possible — or at least a little easier.

But Husseini Manji, head of neuroscience research and development at Janssen Pharmaceutical Companies in Titusville, New Jersey, cautions against assuming that results in mice will bear out in humans.

«The methods for achieving transplantation tolerance differ between mice and humans, but the mechanisms that maintain it are likely shared,» said Marisa Alegre, MD, PhD, professor of medicine at the University of Chicago and co-senior author on the study.

«These results are especially exciting because they show that we can take findings in the mouse and possibly apply them at the human patient population,» said Koenig.

Similar to humans, the mice developed tumors at secondary sites including the liver, lung, peritoneum, and diaphragm.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

«By identifying the signals that instruct mouse progenitor cells to become cells that make tubes and later insulin - producing beta cells, we can transfer this knowledge to human stem cells to more robustly make beta cells, says Professor and Head of Department Henrik Semb from the Novo Nordisk Foundation Center for Stem Cell Biology at the Faculty of Health and Medical Sciences.

• Piero Anversa at New York Medical College in Valhalla, New York, and Donald Orlic at the National Human Genome Research Institute in Bethesda, Maryland, used mouse bone marrow to repair damaged mouse hearts.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

«Worms, mice, humans, and even fruit flies show similar effects of intoxication at similar alcohol concentrations,» he says, and human neurons contain a switch similar to that in C. elegans.

UBC Psychiatry Professor Dr. Weihong Song and Neurology Professor Yan - Jiang Wang at Third Military Medical University in Chongqing attached normal mice, which don't naturally develop Alzheimer's disease, to mice modified to carry a mutant human gene that produces high levels of a protein called amyloid - beta.