Sentences with phrase «mice as a model system»

Not exact matches

Using the mouse as an experimental model, LMU neurobiologist PD Dr. Conny Kopp - Scheinpflug and her research group have now demonstrated that the activity of nerve cells in the auditory system has a direct effect on myelinization — higher levels of activity correlate with the formation of thicker myelin sheaths.

And we've learned a lot about that in model systems, such as in fruit flies, worms, and mice.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

The sequencing of the first genome involving a cockroach species may one day serve as a model system comparable to how research on mice can apply to humans.

Enormous projects such as ENCODE (for humans and mice) or modENCODE (for other lab model systems, such as the fly Drosophila or the worm C. elegans) have been devoted to collecting these data in order to analyse and interpret them in the framework of genomic data and to form hypotheses about functions and relations.

«Additionally, the genetically - engineered mouse model will allow us to test potential treatments aimed at correcting achlorhydria, not just for gastric NETS, but also for other diseases of the gastrointestinal system such as Barrett's esophagus (chronic inflammation of the lower part of the esophagus), or hiatus hernia,» says Dr Calvete.

As they develop human clinical trials, Wargo and colleagues also are conducting lab and mouse model research to better understand the mechanisms that connect bacteria and the immune system.

In the study, the fungal infection Candida albicans was introduced to mice or human models of the lung vasculature and as blood was pumped over that system, researchers recorded what happened using highly sophisticated microscopes.

«Importantly, we use mice as models of human beings in research, and so when looking for anti-obesity drugs, we need to fully understand the function of the NPY system in this animal model to understand how similar circuits in humans connect with the body clock.»

Mouse vocalizations are also used as a model system in research into neuropsychiatric disorders such as autism.

The HZI will also provide access to laboratory and animal facilities up to BSL3 and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

Unfortunately, this is not widely appreciated and mammalian models such as mice are generally thought to be the best systems for informing our understanding human physiology and pathophysiology.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

Scientists could also infect animal models, such as mice, with the virus to get a better understanding of how the pathogen affects the neural system.

His laboratory studies early mouse development as a model system to understand molecular mechanisms leading to establishment of pluripotency in vivo.

In the latest issue of Neuron, a team led by Gladstone Investigator Anatol Kreitzer, PhD, and Salk Investigator Edward Callaway, PhD, combined mouse models with a sophisticated tracing technique — known as the monosynaptic rabies virus system — to assemble brain - wide maps of neurons that connect with the basal ganglia, a region of the brain that is involved in movement and decision - making.

The ICS is a large - scale facility open to the community that ensures the generation of mouse models à la carte, the validation of genetic models, the expansion and preservation and distribution of models with the housing department, and offers in its phenotyping department a series of standardized functional analysis of mouse models that can be performed in a comprehensive pipeline or on demand, as well as for more specialized studies, that cover the major functions and key physiological systems.

The experts explain that many of the state - of - the - art technologies are required to tease out relevant information from model systems, whether these be organoids or «classical animal models such as the fruit fly, zebra fish or mouse,» adds Milán.

The origin of the mouse as the principal model system for biomedical research dates back to the start of human civilization.

The award will support graduate students working on the project, and also help offset other costs, such as producing sufficient quantities of the compound analogs, optimization of the nanoparticle delivery system, and the cost of the mice used to model leukemia.

Researchers gain valuable information about the strengths and weaknesses of our immune system using mouse cell models such as used here.

But, rather than studying the entire nervous system of a single model organism, Professor Graybiel has studied one brain region — a portion of the basal ganglia known as the striatum — in mice, rats, cats, monkeys, and humans using a whole range of technologies from microscopy through electrophysiological recordings to genetics.

The HZI will also provide access to laboratory and animal facilities up to BSL3 (including the gnotobiotic unit) and conventional, modified (e.g. knockout, knock - in, reporter) and humanised (e.g. immune system) mice as animal models.

Beginning with the 2010 RX and HS models, the Remote Touch system, featuring a computer mouse - like controller with haptic feedback, was introduced; [108][177] other models have featured touchscreen controls (through the 2009 model year) as a navigation screen interface.

All models include Samsung Pay and can hook up to Samsung's improved DeX Pad that can help to transform your smartphone into a laptop — you can use a keyboard, mouse, and monitor with your smartphone as the nucleus of the system.