Sentences with phrase «mice by gene therapy»

Improving EphB2 levels in such mice by gene therapy completely fixed their memory problems.

Not exact matches

Since patients (and mice) with Usher 1c also have balance problems caused by hair - cell damage in the vestibular organs, the researchers also tested whether gene therapy restored balance.

Inhibiting NF - ƘB in microglia in mice slowed disease progression by 47 percent, says Brian Kaspar, MD, a principal investigator in the Center for Gene Therapy at Nationwide Children's and senior author of the new study.

Indeed, exposure of the protein produced by the nanoparticle - based gene therapy to the gut mucosa prevents inhibitor development and restores clotting - factor activity in mouse models of both haemophilia A and B. «This approach really could hold big benefit for patients,» says Jörg Schüttrumpf, a transfusion - medicine specialist who led one of the studies performed at the German Red Cross Blood Donor Service in Frankfurt.

The blood sugar of the diabetic mice were made normal by the gene - therapy - treated human islets on the right.

Mice in which telomeres have been lengthened by gene therapy tended to live longer in some studies than mice that didn't get the treatmMice in which telomeres have been lengthened by gene therapy tended to live longer in some studies than mice that didn't get the treatmmice that didn't get the treatment.

We were intrigued by the occurrence of hydrocephalus in the brains of these mice and began to investigate the structures within the brain that might be involved — the choroid plexus and the ciliated ependyma,» said corresponding author Alessandra d'Azzo, Ph.D., who holds the Jewelers For Children Endowed Chair in Genetics and Gene Therapy at St. Jude.

Secondly, this is the first research to demonstrate that the loss of hair cells and hearing can be curtailed in USH3 mice by clarin - 1 gene therapy.

«We found that gene therapy blocked progressive hearing loss and improved hearing in treated mice by nearly four orders of magnitude compared to untreated sibling controls,» said Alagramam.

In previous work, Dr. Ryosei Minoda, head of the Department of Otolaryngology at Kumamoto General Hospital, reported that hearing loss was restored by gene therapy to the inner ear of Connexin 30 deficient fetal mice.

A team of Chinese and American researchers led by Dr. Ji - jing Pang of the Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, PR China, and including Jackson Laboratory scientist Bo Chang, M.D., used gene therapy to restore cone function in the retinas of the B6 (A)- Rpe65rd12 / J (005379) mouse, a model of Leber congenital amaurosis — even if the disease has progressed for three months (Li et al. 2011; Pang et al. 2005).

Yet, their efforts to rescue cone function by gene therapy in mid-course LCA stages failed: when applied to 35 - day old Rpe65 - deficient mice, gene therapy restores rod function only (Pang et al. 2010).

La Jolla, CA — A team led by Salk Institute scientists has used gene therapy to reverse infertility in male mice.

Successful creation of transgenic mice by Dr. Jaenisch is considered the first proof of the feasibility of gene therapy in the intact mammalian organism.

Mice treated four days after birth had a median survival of 41 days; by comparison, most mice treated immediately after birth lived for 100 days or longer6, a finding that mirrors earlier gene therapy studiMice treated four days after birth had a median survival of 41 days; by comparison, most mice treated immediately after birth lived for 100 days or longer6, a finding that mirrors earlier gene therapy studimice treated immediately after birth lived for 100 days or longer6, a finding that mirrors earlier gene therapy studies7.

Furthermore, by combining this information with the characterization of mice genetically engineered to develop lung tumours, we attempt to elucidate the key genes driving lung cancer initiation, progression and response to therapy.