Sentences with phrase «mice by infection»

Not exact matches

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

Johns Hopkins researchers report that fetal mice — especially males — show signs of brain damage that lasts into their adulthood when they are exposed in the womb to a maternal immune system kicked into high gear by a serious infection or other malady.

Virgin and his team decided to explore this possibility by studying a mouse model of chronic norovirus infection.

The new study indicates that such infections in the mice cause the number of tuft cells to increase by five - to tenfold, leading the norovirus to replicate more efficiently.

In additional tests, the scientists found they could restore the norovirus infections by transplanting fecal material from untreated mice into mice that earlier had been treated with the antibiotics.

A molecule naturally produced by the immune system protects mice and monkeys against Zika virus infection, an international team of researchers has found.

Dr Kimberley Prior, of the University of Edinburgh's School of Biological Sciences, who led the study, said: «We were surprised by how strongly malaria infection responded to changes in the eating times of the mice they were infecting.

To see if they would suffice to make H5N1 infection less severe, Webby and his co-workers injected mice with DNA for the neuraminidase gene from human H1N1, one of three flu subtypes covered by this winter's flu shot.

Aguzzi and his team tested this by generating mimetic antibodies in tissue sections from the cerebellum of mice which have a similar toxicity to that of a prion infection.

A study by scientists at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health finds New York City house mice carry bacteria responsible for mild to life - threatening gastroenteritis in people, and some of these bacteria may be resistant to antibiotics.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

«From tiny studios to penthouse suites, New York City apartments are continually invaded by house mice,» says lead author Simon H. Williams, BSc, a research scientist at the Center for Infection and Immunity.

Using mouse models Dr Grainger and his team looked at how and where monocytes are programs in response to toxoplasmosis, an infection caused by a common parasite called Toxoplasma gondii.

The researchers first mimicked a hepatitis B infection by inserting the hepatitis B genome into liver cells in mice.

In their research on young mice, for instance, all the subjects died when they were infected with the Nodamura virus, but when Ding's researchers removed the suppressor protein called B2 from the virus, the infected mice began producing huge armies of the virus - attacking siRNAs and lived, unaffected by the otherwise lethal infection.

The Zika virus reproduces in the vaginal tissue of pregnant mice several days after infection, according to a study by Yale researchers.

The upshot of this and other experiments conducted by Bogyo's team is that using ebselen to disable a toxin in C. difficile was enough to significantly reduce the clinical symptoms of the infection and block the persistent gut damage in mice.

The researchers showed that a two - day treatment regimen with partial or selective PPAR - γ agonists (Telmisartan and Rosiglitazone — both FDA - approved drugs) ameliorated the pathological outcomes of infection in mice by inducing expression of glucose transporters.

They'll test it against Pseudomonas infections in mice, and the results of the experiment should be ready by next summer.

For the new study, researchers in Diamond's laboratory, led by first author Helen Lazear, PhD, now at the University of North Carolina at Chapel Hill, tested five strains of the Zika virus in the mice: the original strain acquired from Uganda in 1947; three strains that circulated in Senegal in the 1980s; and the French Polynesian strain, which caused infections in 2013 and is nearly identical to the strain causing the current outbreak.

«Mouse study reveals potential drug target for arthritis caused by chikungunya virus: A specific immune system proteinase may promote arthritic inflammation after viral infection.»

By 10 days after infection, most mice had no free parasites in their blood.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

Deer mice carry hantavirus, a viral infection spread by the critters» urine and droppings.

To study the still unknown pathogenesis of the disease, the researchers developed a mouse model susceptible to the full range of infection by the human parasite.

By day six, mice begin to exhibit the telltale physical symptoms that indicate the infection has become fatal.

Following transmission by mosquitoes, the early specific (also called adaptive) immune response to WNV is thought to be dominated by antibodies, and, consistent with this, the researchers found that older mice had less potent WNV - specific antibody responses during the early phase of infection.

The Borrelia bacteria that cause Lyme disease are carried by small mammals such as mice and shrews, from which the ticks pick up the infection and transmit it to humans.

The researchers manipulated a nutrient in the drinking water of mice that is used by malaria parasites during an infection — just as a gardener might manipulate nutrients through fertilizers to favor certain plants.

Women plagued by repeated urinary tract infections may be able to prevent the infections with help from over-the-counter painkillers, new research in mice shows.

Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.

To investigate this, researchers from San Diego State University, USA, led by Roberta Gottlieb and Ralph Feuer, first established a mouse model of mild juvenile CVB infection.

In a study published online October 8 by the Journal of Biological Chemistry, researchers found that mice that died of a «mad cow» infection failed to show any of the enzyme - resistant, misfolded prions.

Earlier research by Rafi Ahmed of Emory University found that such viral infections in mice stall the innate immune response by flicking on the PD - 1 switch, which keeps the T cells from functioning.

In an encouraging new development, researchers have designed and tested a topical therapy in mice that prevents infection by one of the most prevalent STDs, genital herpes virus, for days after it is applied.

When the treated mice were subsequently exposed to HSV - 2, the siRNAs thwarted infection by binding to and destroying the RNA of the virus.

«Earlier studies have shown that vitamin E can help regulate the aging body's immune system, but our present research is the first study to demonstrate that dietary vitamin E regulates neutrophil entry into the lungs in mice, and so dramatically reduces inflammation, and helps fight off infection by this common type of bacteria,» said first author Elsa N. Bou Ghanem, Ph.D., postdoctoral scholar in the department of molecular biology and microbiology at Tufts University School of Medicine (TUSM).

Infected, untreated mice showed clear signs of sickness ∼ 4 — 5 d after infection and perished by day 8 — 9.

In mice with a lethal Haemophilus influenzae infection, the researchers found glucocorticoids upregulated IRAK - M expression by enhancing the protein NF - κB p65 and glucocorticoid receptor binding to the IRAK - M promoter.

OE4 vaccination could completely protect mice and cotton rats against later infection by standard forms of RSV.

Immune function and pathology dissected by high - throughput analysis of mice with targeted gene disruptions — an investigation by the Infection and Immunity Immunophenotyping (3i) consortium.

Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D. Broad protection against influenza infection by vectored immunoprophylaxis in mice.

Furthermore, mice that lack Vα14 iNKT cells have been shown to be more susceptible to arthritis induced by Borrelia infection.

(A) Prior to infection, total IFN - γ — producing gp33 - specific CD8 T cells per spleen (CD90, CD8, CD44, IFN - γ) as represented by IFN - γ production in response to gp33 peptide restimulation in immunized and control mice (n = 3).

In the mouse model of NDM - 1 bacterial infection, combination therapy comprising CBS and Carbapenem significantly prolonged the life expectancy and raised the eventual survival rate of infected mice by more than 25 percentage points compared to Carbapenem monotherapy.

April 11, 2018 - A serum developed by Yale researchers reduces infection from malaria in mice, according to a new study.

A serum developed by Yale researchers reduces infection from malaria in mice, according to a new study.

Although the Badovinac study does mention that immunization of B6 Prf1 − / − mice followed by LCMV infection results in mortality with LCMV - specific CD8 T cell expansion (as do naive B6 Prf1 − / − mice), these data were not shown as the focus of the report was on the BALB / c model.

The authors use a new mouse model with infection by two Zika strains including one from the ongoing Brazilian outbreak.

A / J mice are susceptible to infection by Legionella pneumophilia.