Meanwhile, and to the contrary, a second set of remaining «excitatory» neurons saw greater signaling activity when
mice expected a reward based on exposure to the two sensory cues and got one.
Not exact matches
In the current study, researchers found to their surprise that most of the nerve cells in auditory cortex neurons that stimulate brain activity (excitatory) had signaled less (had «weaker» activity) when the
mice expected and got a
reward.
To map how the same sense can be perceived differently in the brain, the NYU Langone team, led by postdoctoral fellow Kishore Kuchibhotla, PhD, monitored nerve circuit activity in
mice when the animals
expected, and did not
expect, to get a water
reward through a straw - like tube (that they see) after the ringing of a familiar musical note.
As part of the test, researchers distracted the
mice with opposing stimuli: If the
mouse was
expecting a flash of light to guide it to the milk
reward, the researchers distracted it with a sound, and vice versa.
The team trained the
mice to
expect a certain
reward and then increased the
mice's expectations by stimulating the GABA - neurons.
After several trials where the
mice expected a higher
reward than they received, they gave up and stopped
expecting a
reward at all.