Sentences with phrase «mice from normal mice»

Not exact matches

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

Top row, eyes from normal mice.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

When various mammals, from mice to monkeys, are either overfed or starved for a few weeks, their weight soon returns to normal levels when free access to food is resumed.

When she compared the «healer» cells from the lupus mice with «nonhealer» cells from normal mice, she noticed several differences.

Male mice from both strains lived 15 per cent longer than normal mice or females.

Normal mice who received marrow from the Hoxb8 «knockouts» groomed themselves compulsively.

The mice were allowed at least 2 weeks for recovery from the implant procedure in order to return to normal function.

Three groups of middle - aged mice (about a year old) were studied: one group ate a normal diet, in which fewer than 30 percent of calories came from fat, while two others were fed high - calorie diets in which 60 percent of the calories came from fat.

The scientists exposed a group of mouse lemurs to moderate chronic caloric restriction (30 % fewer calories than their peers consuming a normal diet) from the outset of early adulthood (Restrikal cohort, see visuals below).

To our amazement, the clearance was unchanged from that in normal mice.

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

If human body clocks are similar to mouse ones, Sato's study suggests that people suffering from jetlag could adjust their eating patterns to get their internal clocks back to normal more quickly.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

For example, normal newborn mouse pups will emit frequent, high - pitched noises when they are separated from their littermates, but VPA - treated pups do not.

That's because the boosted mice produced normal — rather than high — levels of the amyloid precursor proteins from which plaques are made.

Tissue taken from mice with the C. elegans gene had significantly higher levels of omega - 3 acids compared with that of normal animals, the team found.

And normal mice showed no ill effects from the drug.

Her team took purified extracts of the miRNA from stressed mice and injected them into normal embryos.

When the Stanford team measured pyrophosphate levels in cultured cells derived from ank and normal mice, they found that the chemical accumulated in cells from the ank mice but decreased in the culture medium.

The normal mice's brain plaques seemed to be built from human A-beta protein, and the only source of that was the blood of the mutated partner mouse.

They destroyed the T cells in 12 mice, five of which received marrow cells from normal mice while seven received marrow from mice with a defective Fas - ligand gene.

Removing a single gene from the brains of mice and zebrafish causes these animals to become more anxious than normal.

They expected eggs to be more complex, but last year, Hayashi made PGCs in vitro with cells from a mouse with normal coloring and then transferred them into the ovaries of an albino mouse.

In another experiment, the research team transferred infection - combatting white blood cells — called neutrophils — from normal mice to genetically mutated mice.

A new study has determined that mice that spent time running on wheels not only developed twice the normal number of new neurons, but also showed an increased ability to distinguish new objects from familiar objects.

During her postdoctoral work, Bissell noticed that removing mammary cells from a mouse and putting them into a culture dish caused them to lose not only their normal in vivo shapes, but also their ability to secrete milk.

Chen observed no such growth, however, when she treated retinal explants from normal mice with a compound that blocks apoptosis.

The scientists first compared mouse megakaryocyte cells created from embryonic stem cells engineered to lack p45 - Nfe2 with normal megakaryocytes.

Dr. Baran Sumer (left) and Dr. Jinming Gao (right) and have invented a transistor - like threshold sensor that can illuminate cancer tissue, helping surgeons more accurately distinguish cancerous from normal tissue in mouse models.

The purple GM tomatoes have already been found to prolong the lives of cancer - prone mice and in the latest findings they also more double the normal shelf life of tomatoes from an average of 21 days to 48 days.

In an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythm.

To see whether it was a true functional organ, his team transplanted the small thymus from normal mice into mutant, thymus - free animals.

In the latest study, the researchers injected the nine miRNAs into zygotes from normal mice, implanted the zygotes in females, and allowed them to mature.

Song says the amyloid - beta traveled from the genetically - modified mice to the brains of their normal partners, where it accumulated and began to inflict damage.

Not only did the normal mice develop plaques, but also a pathology similar to «tangles» — twisted protein strands that form inside brain cells, disrupting their function and eventually killing them from the inside - out.

As a final test to see whether parasites could directly access the brain from the blood, the researchers infected mice with a mixture of normal parasites and mutants that was unable to reproduce, each labeled in different colors.

In July, he and researchers from the University of Hawaii published evidence that apparently normal mouse clones can possess fundamental defects.

In the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal mice.

Mice generated from embryonic stem cells in which ion channel genes have been mutated by homologous recombination often have a perfectly normal heart.

Untreated 3xTg mice displayed impaired learning and memory as expected, but 3xTg mice that were administered PD146176 for 3 months were indistinguishable from normal mice in a memory test.

(Left) Blood smears from anemic mice indicate irregular shapes of red blood cells; (right) wild type mice indicate normal shapes of red blood cells.

But because mice are naturally social and communicative, and their normal activities — such as how often they groom or play — are well known, those that diverge from the norm are fairly easy to study.

By transferring part of the gut bacteria from healthy mice to diabetic mice, they are re-establishing a normal level of cathelicidin.

As controls, fibroblasts and secretions from normal lab rats, mice, and another rodent called the spiny mouse were powerless to stop the human cancer cells growing.

The neurons were taken from normal mice.

On the flip side, said Tran, PGC1 alpha transgenic mice, which had increased expression of these genes, were particularly resistant to various stressors and recovered from injury much more than quickly than animals with normal regenerative abilities.

Ward's lab team took skin tissue samples from her well - established psoriasis transgenic mouse model, called the KC - Tie2 mouse, and compared it to skin tissue samples of normal mice.

Kipnis and his colleagues wondered how smart mice would be if they had a normal supply of T cells everywhere in their bodies except the meninges, so he injected a compound into mice that prevented T cells from reaching the meninges.

This time, Xu used a sophisticated technique called droplet digital PCR to count the ribosomal DNA copies in normal and cancer cells from the mice.