Tumors grew in all the mice, but the tumors in
mice given the compound were about half the size of those in mice without the compound.
Surprisingly, an even lower percentage — only 20 percent — of
the mice given both compounds developed cancer.
Not exact matches
In a final experiment, the group
gave the animals a
compound that prevented LPA from binding to its receptor on
mouse brain cells, right before they were injected with hydrocephalus - inducing LPA.
When the researchers implanted the skin of the pregnant
mice with time - release capsules containing either a
compound that inhibits IDO or a control substance, only one group rejected fetuses:
mice that had been
given the inhibitor and were carrying genetically foreign fetuses.
They found no difference in the number of plaques or the total amount of amyloid beta between the
mice that received the
compound and those
given just saltwater.
Levels of APOE protein dropped by about half in
mice given the APOE
compound as compared with those that received the placebo oligo or saltwater.
Then they
gave the
mice a
compound called (S)-4-carboxyphenylglycine (S -4-CPG), a placebo or nothing at all.
Still, Zuker was adamant: Knock out either of the two subunits on the protein receptor he identified and laboratory
mice lose all sense of sweet, regardless of which
compounds they're
given.
In one group of
mice, he and his colleagues dosed their mothers with a synthetic
compound that simulates a mild viral infection during late pregnancy; when their offspring hit early puberty at about 6 weeks of age, the young
mice were exposed to unpredictable stress, such as being restrained, deprived of water, or
given electric foot shocks.
Moreover, normal
mice, ordinarily killed or disabled by an ischemic stroke, were
given a shot of a
compound that blocks the action of IL - 21.
The CAM and zebrafish in vivo assays and the ex vivo
mouse aortic ring assay clearly identify kahweol as a new anti-angiogenic
compound, but
gives no information on which specific steps of angiogenesis are targeted by this
compound.
In one set of experiments, when the scientists boosted insulin resistance by
giving mice a
compound that cuts insulin signaling, they saw increased expression of several markers of aging in beta cells.
However, to be effective, the VTS - 270
compound has to be
given for the life of the
mouse.
Giving obese
mice a
compound in green tea slowed their weight gain, according to Penn State scientists.
Mice which had ingested epicatechin, a compound found in dark chocolate, suffered significantly less brain damage after undergoing induced stroke than mice which had not been given this compo
Mice which had ingested epicatechin, a
compound found in dark chocolate, suffered significantly less brain damage after undergoing induced stroke than
mice which had not been given this compo
mice which had not been
given this
compound.
In the animal study, researchers divided a group of 52
mice with colon cancer tumors into three groups: a control group, a group fed the grape
compounds and a group
given sulindac, an anti-inflammatory drug that an earlier study showed decreased the incidence of tumors.