Sentences with phrase «mice lack»

In fact, 5 - HT2AR knockout mice lack drug - elicited HTR.

You can't translate lifespan changes directly, because we already have a variety of improvements in our biochemistry that mice lack.

Mice lack such ECM, which means that they generate fewer neurons and have a smaller brain.

Such mice lack a gut microbiome and do not develop this kind of immune cell.

Mice lack colonic BMI - 1 stem cells that play a critical role in how colon cancer forms — or carcinogenesis — and how material passes through the cell lining of the intestinal wall — or gut permeability.

To investigate further, the team studied mice lacking a functional PER3 gene.

When TNF - alpha action was blocked in the mice lacking ATG16L1, their damaged guts underwent repair and the mice survived.

The researchers discovered mice lacking ErbB4 have low levels of a particular neurotransmitter — GABA, or gamma - aminobutyric acid — in their brain.

In a study published in the current issue of Neuron, researchers showed mice lacking ErbB4 activity in specific brain regions performed poorly on timed attention tasks.

In 2006, Paul Greengard, a neuroscientist at the Rockefeller University in New York, and his colleagues created mutant mice lacking the gene, and found that the animals developed depression - like behaviours.

We also discovered that when we depleted neutrophils, nerve debris clearance was significantly halted in both normal mice and mice lacking a major population of macrophages.»

Periasamy also found that mice lacking sarcolipin piled on weight, which suggests the protein may help combat obesity (Nature Medicine, doi.org/jbc).

A study in this issue of JCI Insight demonstrates that mice lacking the proinflammatory signaling molecule TAK1 are protected from obesity and insulin resistance induced by a high fat diet.

They validated the cell models and showed that changing clock gene function in these cells is similar to what happens in mice lacking clock genes.

Mice lacking IRF1 showed much higher levels of the bacteria when infected, and 100 percent succumbed to the infection, compared with only 25 percent of the mice that have IRF1.

Previous research has shown that mice lacking CBX2 are sterile, but Biason - Lauber says it's too early to tell whether her team's patient will be infertile as well.

We generated knockout mice lacking synaptobrevin / VAMP 2, the vesicular SNARE protein responsible for synaptic vesicle fusion in forebrain synapses, to make use of the exquisite temporal resolution of electrophysiology in measuring fusion.

A team led by Antonia Sassmann - Schweda of the Max - Planck - Institute for Heart and Lung Research and colleagues generated mice lacking TAK1 specifically in adipocytes.

They saw that mice lacking this protein were protected from synapse loss via similar pruning mechanisms or other pathways that protect neuron health.

If mice lacked this type of ipRGC, the only change Hattar could find was that the animals could no longer constrict their pupils.

Looking forward, the researchers plan to investigate knockout mice lacking the gene that produces AGF to further define its role.

Then, he found that mice lacking Klotho died young, after developing arteriosclerosis and other age - related conditions much earlier than normal (Science, 7 November 1997, p. 1013).

While 80 percent of normal mice are able to handle a temperature drop, all mice lacking ERRγ did not tolerate the cold.

And by studying mice lacking the gene for ERRγ (and therefore unable to make the ERRy molecule), the team observed that all brown fat cells resembled white cells in these mice.

Those findings prompted the two teams to work together to breed mice lacking four genes: three hoxd genes and a mouse version of hoxa - 13, which together are known to direct the development of limb ends.

But treatment with leptin does cure obesity in mice lacking leptin, so it's «possible,» O'Rahilly says, that similar treatment could help the few people who do have leptin defects.

In mice lacking MHCI, both kinds of stimulation made connections stronger.

Past studies have shown that adult mice lacking the receptor that binds two types of interferons, interferon - α and interferon - β, are highly susceptible to Zika.

Just 11 weeks after getting a single shot of the gene therapy, 10 young mice lacking the ob / ob gene reached weight, insulin, glucose, and leptin levels comparable to normal mice.

In the new work, scientists from New York City, St. Louis and China found that such spacing is disrupted in mice lacking the Pcdhαc2 gene.

The researchers also demonstrated NOX's involvement by showing that mice lacking the NOX proteins had fewer HSCs in the liver after hepatotoxin exposure.

The scientists will now look into possible techniques to restore the function of pejvakin, particularly using gene therapy, which has already proved successful in conserving hearing in mice lacking in pejvakin, even when they are overexposed to noise.

Mice lacking certain sequences had abnormally low numbers of brain cells that have been implicated in the progression of Alzheimer's disease.

Mice lacking both genes displayed more pronounced abnormalities.

Using direct, controlled acoustic stimulation, the scientists were able to prove that the auditory system of mice lacking in pejvakin is affected by their acoustic environment.

They found that mice lacking Esrp1 alonewere born alive but with cleft palate and cleft lip deformities that prevented feeding.

Because mice lacking both genes would not be born alive, the scientists followed up this lead by making «conditional knockout mice,» in which Esrp1 and Esrp2 activity was normal early in fetal development, but then was switched off in skin epithelial cells.

Using mice in which the production of the enzyme was blocked, the researchers found that mice lacking FIH in their muscles require more oxygen than normal when exercising.

The researchers found that mutant mice lacking Del - 1 had more severe attacks of the EAE than normal mice, with more damage to myelin, the fatty sheath that coats neurons and helps in the transmission of signals along the cell.

Through study of mice lacking Sp7, Javed and colleagues found that initial tooth morphogenesis was normal, even though the animals lacked mineralized tooth sockets.

Since it is known that 13 different members of the fibroblast growth factor, or Fgf, family act as signaling proteins between the two different tissues — dental mesenchyme and oral epithelium — during murine tooth development, Javed and colleagues looked for changes in Fgf ligands in the mice lacking Sp7.

To explore these questions Akiko Iwasaki, professor of immunobiology and investigator of the Howard Hughes Medical Institute, and her co-authors observed replication of the Zika virus in the vaginal tissue of control, wild - type mice (genetically unmodified mice) and mice lacking genes that regulate immune system proteins known as type I interferons.

In this study, the team was able to piece together the biological process that leads to the production of new bone by studying the offspring of mice lacking the Gastric Intrinsic Factor gene, which is active in the stomach and allows the gut to absorb vitamin B12.

In an article entitled «Prion protein modulates monoaminergic systems and depressive - like behavior in mice» and published in the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kuru.

Mice lacking the HSF1 gene showed structural brain abnormalities and were prone to seizures after birth following exposures to very low levels of toxins.»

In a new study published online May 28 in the journal Cell Metabolism, Knutson and colleagues found that mice lacking ZIP14 — when mated with mice with hemochromatosis — did not load iron in the liver.

Wondering whether other enhancers pick up the slack — providing a backup system to keep limb development on track — Osterwalder and his colleagues bred mice lacking a pair of enhancers specifically implicated in digit formation.

Female mice lacking L2 in their eggs ovulate and are otherwise healthy, but they produce no offspring.

«But the definitive proof can only come from a mouse lacking PK2.»

Specifically, they determined that the immune systems in genetically altered mice lacking the critically important calcium channel component STIM1 failed to control TB, leading to severe lung inflammation and premature death.