Not exact matches
He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in
mouse models of kidney
disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.
«It would be interesting to
model some of these
diseases in
mice and see if supplementing NMN provides any benefit to their behavior or memory.»
Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a
mouse model of the
disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.
To better understand their findings, the team examined the animal
model for APS1 (i.e.
mice with the same genetic defect as human patients with the syndrome) and found that male
mice spontaneously developed an inflammatory
disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.
For researchers using
mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious
diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with
disease progression.
These findings allowed researchers to create a chimera virus: a
mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal
model of
disease, treating not only human herpes virus infection but also its associated cancers.
Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in
mice models of
disease.
The behavioral tests used here
modeled one dimension of the
disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in
mice than in humans, he says.
By directly manipulating a portion of the prion protein - coding gene, Whitehead Institute researchers have created
mouse models of two neurodegenerative
diseases that are fatal in humans.
To unravel exactly how ADAR1 is connected to
disease severity at a molecular level, the researchers transferred multiple myeloma patient tissue to
mice, creating what's known as a xenograft or «humanized»
model.
«Most
mouse models produce pathology that only distantly resembles human
diseases.
Sinclair thinks that these
mouse models indicate that resveratrol may be effective in preventing age - related
diseases in humans, like cancer, heart
disease and type 2 diabetes.
We demonstrated that DENV serotype 2 (DENV2)-- specific human monoclonal antibody (HMAb) 2D22 is therapeutic in a
mouse model of antibody - enhanced severe dengue
disease.
Guo and his collaborators continue their studies by establishing additional
mouse models of leukemia that have been transplanted with patient cells of relapsed and refractory
disease.
Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes of twins with and without MS. Finally,
mouse models of MS are not perfect mimics of the human
disease, and
mouse immune systems aren't identical to people's.
The new research investigated the effectiveness of MSC therapy in a
mouse model of chronic inflammatory lung
disease, which reflects some of the essential features of
diseases such as COPD and cystic fibrosis.
Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop
disease progression in
mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of nerve cells, which protected them from free radicals and structural damage.
A drug that acts like a growth - promoting protein in the brain reduces degeneration and motor deficits associated with Huntington's
disease in two
mouse models of the disorder, according to a study appearing November 27 in the Journal of Neuroscience.
For the research, the scientists used the platform to target colon macrophages in order to reduce inflammatory symptoms caused by Inflammatory Bowel
Disease (IBD) in
mouse models.
The study involved laboratory cell lines of human leukemia and
mouse models of the
disease.
The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a
mouse model of the
disease and in human cells.
The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and
mouse models of the
disease.
«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in
mouse models of the
disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.
«This is the first time a compound targeting Gaucher
disease has been tested in a mouse model of Parkinson's disease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's D
disease has been tested in a
mouse model of Parkinson's
disease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's D
disease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's
DiseaseDisease.
Now Perry and Holmes have built up a detailed picture of how this happens through experiments in
mice with prion
disease, a
model of neurodegeneration.
In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in
disease suppression and increased overall survival in
mouse models.
Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a
mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative
disease.
We have
mouse models for many of these
diseases, says Zeng, so we can treat the brains of affected animals with the same dye - and - dice approach.
Most importantly, these cells protected
mice from developing diabetes in a
model of
disease, having the critical ability to produce insulin in response to changes in glucose levels.
«This
mouse model also will be useful in studies to further investigate impact of the omega - 3 omega - 6 ratio in
disease prevention and treatment.»
So until recently, much of what scientists learned was gleaned by inference or from studying
mouse models of the
disease.
Recently research published in Cancer Discovery showed that changing the schedules of drug administration can improve outcomes leading to more complete responses in
mouse models of the
disease.
Blocking this inflammation after radiation therapy brought a significant improvement in survival in a
mouse model of the
disease.
Additionally, work in a
mouse model revealed similar cells, indicating that the progenitors are conserved from
mouse to human, and therefore, they must be «important cells with promising potential for cell therapy in treating liver
disease,» explained Dr. Gouon - Evans.
«Gut microbes promote motor deficits in a
mouse model of Parkinson's
disease.»
Antibiotic treatment reduced motor deficits and molecular hallmarks of Parkinson's
disease in a
mouse model, whereas transplantation of gut microbes from patients with Parkinson's
disease exacerbated symptoms in these
mice.
She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as
mouse models, to look at the protein in
diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.
This anxious behavior mirrored that of CdLS patients, while autopsied brain tissue from individuals with CdLS showed symptoms of
disease that matched those of the experimental
mice suggesting that they were a good animal
model.
This was observed in human ovarian cancer cells grown in culture, and then in
mouse models of the
disease.
Desgrosellier said the team will follow up with
mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human
disease.
Studying aging and its associated
diseases has been challenging because existing vertebrate
models (e.g.,
mice) are relatively long lived, while short - lived invertebrate species (e.g., yeast and worms) lack key features present in humans.
Using CRISPR / Cas9, the Hamon Center team was able to correct the genetic defect in a
mouse model of DMD and thus prevent the development of features of the
disease, which in boys causes progressive muscle weakness and degeneration, often along with breathing and heart complications.
Most animal studies of the
disease are conducted with laboratory
mice that have been genetically engineered and bred to
model ALS, but for this research, investigators used rats with ALS because they more accurately portray the
disease's variable course in humans.
The prevention of dilated cardiomyopathy in a
mouse model by feeding a high - fat diet signals an advance in the understanding of the mechanisms involved in heart
disease and has implications for the future development of treatments for this condition.
«This research project is a prime example of how
mouse models can help us to better understand cancer
diseases in human beings,» says Sabine Harlander.
In Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and
Disease Progression in Heart Failure: Critical Importance of the Cardiosplenic Axis, Prabhu and colleagues showed that immune cells that are stored in the spleen were intricately involved in the heart failure that follows a heart attack, or infarction, in a
mouse -
model system.
This molecule, Del - 1, is the same regulatory protein that has been found to prevent inflammation and bone loss in a
mouse model of gum
disease.
While the
mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal
models to further study the course of
disease and its transmission.
The team also showed that they could recover muscle growth and function in
mouse models of muscular dystrophy, a
disease with a known gene mutation.
He returned to St. Louis and shifted several members of his lab to studying Zika, including developing
mouse models of the
disease.