Sentences with phrase «mice models of»

The method has been successfully tested on mice models of leishmaniasis.

The research team, led by Akiko Iwasaki, professor of immunobiology and Howard Hughes Medical Institute investigator, decided to investigate using mice models of herpes simplex virus - 1, the dominant cause of genital herpes in the United States.

The scientists are testing the ability of drugs already on the market to reverse this cellular transformation in the pancreas in mice models of human pancreatic cancer.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Other rows are eyes from three different mouse models of diabetes.

New research shows that in a mouse model of childhood absence epilepsy, brain activity is perturbed between seizures.

The researchers tested their drug compound, Targapremir - 210, in mouse models of triple negative breast cancer.

Jeffrey Noebels and his team at Baylor College of Medicine in Houston, Texas used two genetic mouse models of absence epilepsy and compared them to unaffected mice.

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

A new mouse model of a genetically - linked type of autism reveals more about the role of genes in the disorder and the underlying brain changes associated with autism's social and learning problems.

Speaking about the research, Dr Hawkins said: «We were really surprised that loss of PTEN caused such a dramatic increase in PI (3,4) P2 in our mouse model of prostate cancer.

Led by graduate student Patrick O'Hern, the team at Brown and the University of Cologne in Germany uncovered a complex cause - and - effect sequence in both C. elegans worm and mouse models of SMA.

Researchers have used CRISPR to treat an adult mouse model of Duchenne muscular dystrophy.

So far, gene therapy attempts have only resulted in partial improvements of hearing in mouse models of specific human deafness forms that did not include severe anomalies in hair cell structure.

That, he says, suggests that the widely used mouse model of cystic fibrosis «might not be appropriate.»

Virgin and his team decided to explore this possibility by studying a mouse model of chronic norovirus infection.

By directly manipulating a portion of the prion protein - coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans.

However, Walker Jackson, a former postdoctoral researcher in Lindquist's lab is changing that, creating novel mouse models of human fatal familial insomnia (FFI) and CJD.

Heber - Katz says another scientist working with the mouse model of lupus also noticed the closing ear holes, but thought of it as an inconvenience rather than a eureka moment, saying, «These darn mice, you have to keep going upstairs to punch holes in their ears!»

And Duff's lab has unpublished data suggesting that trehalose lessens tau pathology and improves behavior in mouse models of neurodegeneration.

We demonstrated that DENV serotype 2 (DENV2)-- specific human monoclonal antibody (HMAb) 2D22 is therapeutic in a mouse model of antibody - enhanced severe dengue disease.

Guo and his collaborators continue their studies by establishing additional mouse models of leukemia that have been transplanted with patient cells of relapsed and refractory disease.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes of twins with and without MS. Finally, mouse models of MS are not perfect mimics of the human disease, and mouse immune systems aren't identical to people's.

«It's very difficult to produce a mouse model of a solid tumor of the type we see in most women who are diagnosed with cervical cancer.

A regulated pulse of insulin secretion resulted in a transient correction of serum glucose concentrations in a mouse model of hyperglycemia.

And in a mouse model of Alzheimer's, having more TREM2 in the brain seemed to relieve inflammation and amyloid buildup, slow the loss of neurons and preserve the animals» cognitive abilities.

This is an image of neurons in the somatosensory cortex of mouse models of epilepsy used in the study.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

The new research investigated the effectiveness of MSC therapy in a mouse model of chronic inflammatory lung disease, which reflects some of the essential features of diseases such as COPD and cystic fibrosis.

A drug that acts like a growth - promoting protein in the brain reduces degeneration and motor deficits associated with Huntington's disease in two mouse models of the disorder, according to a study appearing November 27 in the Journal of Neuroscience.

The study involved laboratory cell lines of human leukemia and mouse models of the disease.

Daria Mochly - Rosen and her team at Stanford have previously identified a molecule, P110, that can restore mitochondrial function and prevent neuronal death in mouse models of HD.

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

The scientists tested the new compound using a mouse model of TB and found that substituting R207910 for one of three antibiotics in a treatment cocktail significantly reduced the time required to clear the animals» lungs of bacteria.

When the team used the retinoid fenretinide along with anti-estrogen therapy in mouse models of breast cancer, they did not see the expansion of CK5 + cells previously seen with anti-estrogen therapy alone.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

«Gene therapy restores hearing in deaf mice, down to a whisper: Improved delivery vector better penetrates the inner ear, also restores balance in a mouse model of Usher syndrome.»

In one example highlighted by the researchers, mouse models of T - ALL were treated either with a combination of mTOR inhibitor pp242 and the chemotherapy drug AraC, or they were treated with just AraC or pp242.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

Studies in mouse models of HD showed that creatine raises brain ATP levels and protects against neurodegeneration.

«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.

The researchers used two different mouse models of diabetes to study the effects of the diet.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

«This is the first time a compound targeting Gaucher disease has been tested in a mouse model of Parkinson's disease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's Disease.

The new study, using an experimental mouse model of diabetes, is published online in the journal PLOS One.

Working with mouse models of cancer, they demonstrated how treatment with antibiotics on top of chemotherapy may be significantly superior to treatment with chemotherapy alone.

In this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich's ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration.