Sentences with phrase «mice on a high fat diet»

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Influence of intermittent fasting and high - fat diet on morphological changes of the digestive system and on changes of lipid metabolism in the laboratory mouse

By combining each mouse's genome, phenome, proteome and metabolome, the scientists were able to identify a particular gene, located on their chromosome 2, and whose presence plays an important role in the development of type 2 diabetes «The mice with a high - fat diet are more or less likely to develop diabetes depending on whether this gene is active or not,» said Evan Williams, LISP PhD student and the article's co-first author.

They identified 21 of these microRNAs that were expressed differently in the sperm of mice fed on a high fat diet compared with those on a healthy diet.

«Binge - eating mice reveal obesity clues: Mice fed on a high fat or chocolate - based diet show abnormal feeding behaviors such as snacking, bingeing and disrupted eating patterns.&ramice reveal obesity clues: Mice fed on a high fat or chocolate - based diet show abnormal feeding behaviors such as snacking, bingeing and disrupted eating patterns.&raMice fed on a high fat or chocolate - based diet show abnormal feeding behaviors such as snacking, bingeing and disrupted eating patterns.»

Fat tissue taken from mice on a high - fat diet rich in omega - 3 fatty acids (right) has fewer inflammatory immune cells (shown in green) than fat tissue taken from mice that did not receive the omega - 3 supplement (lefFat tissue taken from mice on a high - fat diet rich in omega - 3 fatty acids (right) has fewer inflammatory immune cells (shown in green) than fat tissue taken from mice that did not receive the omega - 3 supplement (leffat diet rich in omega - 3 fatty acids (right) has fewer inflammatory immune cells (shown in green) than fat tissue taken from mice that did not receive the omega - 3 supplement (leffat tissue taken from mice that did not receive the omega - 3 supplement (left).

They found that the mice with the new bacteria gained significantly more weight on a high fat diet than control mice, also on a high fat diet (International Society for Microbial Ecology, doi.org/jz9).

The findings build on a 2015 UCLA study that demonstrated that both green tea and black tea helped prevent obesity in mice that consumed a high - fat, high - sugar diet.

BYE BYE BUDS Mice that became obese on a high - fat diet (right) lost a quarter of their taste buds (stained red) and also had fewer progenitor cells (stained green)-- which give rise to new taste buds — than mice of a healthy weight on a regular diet (leMice that became obese on a high - fat diet (right) lost a quarter of their taste buds (stained red) and also had fewer progenitor cells (stained green)-- which give rise to new taste buds — than mice of a healthy weight on a regular diet (lemice of a healthy weight on a regular diet (left).

Eggen and his collaborators investigated the impact of high - and low - fat diets on inflammation and microglial markers in a specific brain region — the hypothalamus — of 6 - month - old mice.

The team found that mice on a high - fat diet gained weight less rapidly if fibre was added to their food.

Mice given an experimental vaccine developed by Cytos Biotechnology in Zurich, Switzerland, remained an impressive 15 percent lighter on an all - you - can - eat high - fat diet.

Four recent studies in mice, rats and monkeys suggest that a high - fat diet during pregnancy may have adverse effects on offspring, adding another item to the list of things moms - to - be might fret about.

Experiments with mice show that after just four weeks on a high - fat or a high - sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet.

In this research, after just four weeks on a high - fat or a high - sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet.

On the other hand, as they aged, these «knockout mice» grew fatter than the normal mice, especially when fed a high - fat diet.

Experiments showed that mice unable to produce AIM fed on a high - fat diet for a year developed multiple liver tumors.

These researchers wanted to observe the effects of citrus flavanones for the first time on mice with no genetic modifications and that were fed a high - fat diet.

The high - fat diet without the flavanones increased the levels of cell - damage markers called thiobarbituric acid reactive substances (TBARS) by 80 percent in the blood and 57 percent in the liver compared to mice on a standard diet.

Female MRI MRI images reveal far greater amounts of abdominal fat (in red) in mice exposed to low doses of penicillin and fed a high - fat diet as opposed to mice fed only a high - fat diet (image on left).

PLAQUE BE GONE A sugar called cyclodextrin stopped cholesterol crystals (white) from building up in the arteries of mice on a high - fat diet.

Mice were on the high - fat or lower - fat diet for four weeks before transplantation and maintained on the same diet after transplantation.

When the team fed mice a high - fat diet for 18 weeks, those also given aspartame put on more weight than those that weren't.

Transplanted hearts lasted in four groups of mice as follows: • 21 days: mice with hyperlipidemia caused by a genetic mutation of apolipoprotein E (ApoE) placed on a high - fat diet • 51 days: healthy mice placed on a high - fat diet leading to hyperlipidemia • 61 days: mice with hyperlipidemia caused by a genetic mutation of ApoE on a lower - fat diet • More than 100 days: healthy mice placed on a lower - fat diet

Surprisingly, the mice on high - fat diet moved less before they gained the majority of the weight, suggesting that the excess weight alone was not responsible for the reduced movements.

«Our previous results on mice showed that replacing some of the fat in a diet high in saturated fats from coconut oil with soybean oil — to achieve a level common in the American diet — causes significantly more weight gain, adiposity, diabetes and insulin resistance than in mice fed just the high - fat coconut oil diet,» Sladek said.

They found that adding one particular set of these compounds, known as oligomeric procyanidins (PCs), to the food made the biggest difference in keeping the mice's weight down if they were on high - fat diets.

The researchers also set parameters to assess the impact of the effects of the high - fat, high - calorie diet on mouse pancreas tissue, such as increased inflammation and other biological signs that indicate pancreas problems.

In a set of papers out today in the journals Nature Genetics and Nature Communications, researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms that promote metastasis in the mouse model and also implicated the typical Western high - fat diet as a key environmental factor driving metastasis.

Working in mice that were put on high - fat diets to model diabetes, «we demonstrated that obesity increases the expression of pro-inflammatory genes in abdominal fat, but not in other organs such as the liver or muscle, nor in subcutaneous fat,» says Jongsoon Lee, PhD, Assistant Investigator in Joslin's Section on Pathophysiology and Molecular Pharmacology and Assistant Professor of Medicine at Harvard Medical School.

The mice fed on a low calorie diet were found to experience an extreme increase in NPGL expression, while the 5 - week high - fat - diet group saw a large decrease in NPGL expression.

After 6 weeks on a high - fat diet, 85 % of the F4 / 80 + cells in periepididymal adipose tissue of the recipient mice were donor - derived (i.e., CD45.1 +).

During this period, the mice on the high - fat diet gained 30 to 50 percent more body mass than mice fed a normal diet, and they developed more intestinal tumors than mice on a normal diet.

However, the stem cells from mice on a high - fat diet were more able to function on their own.

The mice were placed on high - fat diets, which raise the chances of developing the two conditions.

First, they found that the mice on a high - fat diet had many more intestinal stem cells than mice on a normal diet.

Publishing in the journal Cell a group of scientists have published their research working on mice which reports that a high fat diet of the mother can bring about a shift in gut microbes that negatively impacts the social behaviour of the offspring mice.

Among their experiments, the researchers studied beta cell signaling in mice that were modified to lack expression of the proteins and experienced insulin resistance by being placed on a high - fat diet, or aging, or becoming pregnant.

Of note today: non-exclusive breastfeeding increases the risk of HIV transmission via the alteration of gut microbiome / T - cell activation; Fasting altered the gut microbiome in beneficial ways but only in mice previously fed a high fat diet; An investigation into new species of the honey and bumblebee gut commensal genus Gilliamella; Catfish development shapes gut microbial community structure independent of diet; A metagenomic analysis of the skin microbiome of the frog, Craugastor fitzingeri; The microbiome is altered during the bioremediation of herbicide contaminated soil; The impact of urban density on the soil microbiome; A randomized placebo controlled clinical trial of a microbiota based drug for the prevention of Clostridium difficile Infection; and the virome of the Cuatro Ciénegas Basin of Mexico

Surprisingly, the effects of obesity on gut bacteria, inflammation, and osteoarthritis were completely prevented when the high fat diet of obese mice was supplemented with a common prebiotic, called oligofructose.

On either chow or high fat diet, A / J mice maintain low glucose and insulin levels.

Mice lacking the IRX3 gene not only weighed 25 percent to 30 less than those that had it, these animals didn't gain any weight on a high - fat diet and were seemingly resistant to diabetes.

Mice fed on a high - fat diet showed increased levels of free fatty acids in their blood.

Mice on the high - fat diet become much more obese and more insulin - resistant compared to their peers on the glucose diet.

To illuminate the physiological role of TRIP - Br2 on fat storage and metabolism, the scientists conducted experiments on mice genetically engineered not to produce TRIP - Br2, known as KO (knock out) mice, which were fed either a low - fat diet or a high - fat diet.

After eight weeks on a high - fat diet, mice that had been engineered with genes to activate the Hedgehog signaling pathway didn't gain weight (left), but control animals whose Hedgehog pathways were not activated became obese (right)(Credit: Long Lab)

The treatment lowered liver weight and improved glucose tolerance among mice on any diet, but most strikingly among those on the high - fat / high - fructose diet.

Over an eight - week period, a control group of mice fed a high - fat diet predictably became obese, but the mice whose Hedgehog pathway had been activated didn't gain any more weight than another control group fed on a normal diet.

To explore if Hedgehog signaling also has an effect on diet - induced obesity after birth, Long and his team genetically engineered mice so that the Hedgehog pathway in fat cells would activate when they ate a high - fat diet.

In addition, the KO mice on the high - fat diet had improved glucose tolerance and insulin sensitivity and lower triglycerides.

The obese mouse on the right was fed a high - fat diet.