Sentences with phrase «mice produce more of»

Hungry mice produce more of the protein encoded by the SIRT1 gene, the team reports in the 3 March Nature.

The reason for this response, Gordon says, was twofold: Firmicutes bacteria transplanted from the fat mice produced more of the enzymes that helped the animals extract more energy from their food, and the bacteria also manipulated the genes of the normal mice in ways that triggered the storage of fat rather than its breakdown for energy.

Not exact matches

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

Fiona Mathews of the University of Exeter, UK, who led the study, says the findings echo those in animals, which are also more likely to produce boys during times of plenty, whereas female mice with low blood sugar also seem more prone to producing girls.

Six pairs of mice — with one mouse engineered to produce gobs of human A-beta and one normal — were surgically joined for a year, causing blood mingling that's far more extensive than that of a blood transfusion.

Indeed, the researchers found that mice fed the drug produced more ABC1, they report in the 1 September issue of Science.

Cutting calories from the diets of mice, fruit flies, nematode worms and yeast led all of the organisms to produce more hydrogen sulfide, Mitchell and colleagues found.

Mice that were genetically engineered to produce higher - than - average amounts of the microRNA were more resistant to constant stress: They did not develop any of the behaviors associated with chronic stress, such as anxiety or depression, which would normally appear.

In 2009, they observed that these «humanized» mice produced more frequent and complex alarm calls, suggesting the human mutations may have been involved in the evolution of more complex speech.

In humans, as in mice, fat cells of the obese already produced plenty of leptin — more in fact than those of their thin counterparts, since the level of leptin was directly proportional to the amount of fat.

«By identifying the signals that instruct mouse progenitor cells to become cells that make tubes and later insulin - producing beta cells, we can transfer this knowledge to human stem cells to more robustly make beta cells, says Professor and Head of Department Henrik Semb from the Novo Nordisk Foundation Center for Stem Cell Biology at the Faculty of Health and Medical Sciences.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

The most intriguing mutant type of mice were unusually thin; they generated more active osteocalcin, secreted more insulin, and produced many times more of the insulin - releasing cells in the pancreas.

Photoswitches inserted into retinal ganglion cells (RGC) of blind mice produce much less variety of response (all evenly red means the cells fire at the same time), while blind mice with photoswitches inserted into bipolar cells (ON - BC driven) exhibit much more variety in their retinal response to light, closer to that of normal mice.

Using mice, this study found that in obesity, CB1 cannabinoid receptors become enriched on the nerve terminals that normally inhibit orexin neuron activity, and the orexin neurons produce more of the endocannabinoids to activate these receptors.

Their answer, garnered through a series of electrophysiology, dendritic spine density and immunohistochemistry experiments with mice that were genetically altered to produce either more new neurons or kill off newborn neurons, supports the second model — some of the cortical neurons transfer their connections from mature granule cells to the new granule cells.

The full mouse connectome would produce hundreds of times more data than can be found on all of Google's computers, says Jeffrey Lichtman, the neuroanatomist leading the Harvard team.

«In our mouse experiments, olive oil produced essentially identical effects as Plenish — more obesity than coconut oil, although less than conventional soybean oil — and very fatty livers, which was surprising as olive oil is typically considered to be the healthiest of all the vegetable oils,» said Poonamjot Deol, an assistant project scientist working in Sladek's lab and the co-first author of the research paper.

So when Drake and his colleagues measured the RNA levels — a direct link to how much of a gene is being produced — in the genes of 334 mice, he didn't expect to find more than a few variations that might help explain why males and females have such different rates of cardiovascular disease and diabetes or why they react differently to certain drugs.

The team found lower levels of TRNP1 in areas that were destined to form folds, and higher levels in areas that would not have developed them, suggesting that the protein produced by the gene inhibits more complex brain development in humans as well as in mice.

In addition, substances called growth factors, produced naturally in the brain, were more abundant in key regions on both sides of the brain in optogenetically stimulated, stroke - affected mice than in their unstimulated counterparts.

In studies of neural development in mice, Stahl found that TRNP1 produces a protein that determines whether neural stem cells self - replicate, leading to a balloonlike expansion of cortical surface area, or whether they differentiate into a plethora of intermediate stem cell types and neurons, thickening the cortex and forming more complex brain structures.

When the total number of wheel revolutions was quantified during the 14 - hour data collection period, IL - 15Rα — KO mice produced 15,090 wheel revolutions (equivalent to 5.4 km), 6.3-fold more than the B6129 control mice (Figure 3B).

Similarly, we observed that male IL - 15Rα — KO mice produced 6.3-fold more wheel revolutions compared with B1629 control mice in cage wheel running experiments and had a larger number of ambulatory photobeam breaks in the light and dark cycles.

Multiple mouse models of SMA have been produced, generally by knocking out the endogenous mouse SMN1 gene and replacing it with one or more copies of the human SMN2 gene that produces much less full - length SMN protein than the SMN1 gene.

Reduction of htt to 50 % endogenous levels produces viable mice with no overt phenotypes (Duyao et al., 1995; Zeitlin et al., 1995) however more detailed evaluation has revealed deficits in cognition and motor behavior (Nasir et al., 1995) raising the possibility that lowered htt starting in development may have adverse effects in the mouse.

However, unlike the mouse, the zebrafish is smaller and can produce more offspring in a shorter time (200 eggs per week compared to a mouse litter of 15 pups in 21 days).

Researchers comparing normal and obese mice found that obese mice produced more than twice as much of a small microRNA molecule called microRNA - 143 in their liversANCHOR.

We hypothesized that this would be sufficient to produce stable increases in progranulin levels in the hippocampus of Grn + / − mice, but were also interested in whether progranulin might be increased in more FTD - relevant regions, such as the frontal cortex.

DartMouse ™ offers clients a marker - assisted congenic breeding strategy to produce congenic mice with > 99 % recipient strain genetic purity in half the time (5 generations; 1.25 - 1.5 years) instead of the more practiced 10 - 20 generations, which can take greater than 5 years.

The extract caused the mice's muscle cells to produce more of pretty much all the proteins that make the insulin receptor work — from the IR insulin receptor to GLUT4 transport protein to insulin - receptor substrate to Akt.

in 2016, genetically identical mice that consumed a high - fat diet were more likely to produce obese offspring with impaired glucose tolerance, an early sign of type 2 diabetes.

More specifically, addition of the PI3K inhibitor LY294002 to the growth medium of mouse muscle cells produces enhanced nuclear localization of FOXO1 and increased MAFbx mRNA transcription (52, 53).

Principal Translations / Traduzioni principali: Inglese: Italiano: mouse, plural: mice n noun: Refers to person, place, thing, quality, etc. (small rodent) Young may refer to: Offspring, the product of reproduction of a new organism produced by one or more parents; Youth, the time of life when one is young

Cat toy companies keep this in mind when producing their products such as toy mice, birds, butterflies and other «prey» on... MORE pole toys, and «chase» toys, such as laser toys to chase a beam of light.

A 2 week course is more than sufficient, especially these days when all the forms, data and real estate clauses are computer produced by the click of a mouse.