In other labs, some intriguing differences between male and female
mice test subjects have already begun to emerge.
Not exact matches
He averred that none of the
mice,
test subjects or controls, had any stomach cancer.
Geneticist Clarence Cook Little suspected cancer was an inherited disease, and
mice — short - lived and low maintenance — were the ideal
test subjects.
Finally, Lowry and his colleagues studied another set of
mice, who were
subjected to a stress - response
test.
Yes, using
mice in early drug studies can spare human
test subjects from harm, which most people would argue justifies the frequently misleading findings.
Cohen
subjected the
mice to a learning
test known as the Morris water maze.
Using this
mouse - tracking software Freeman developed, the millimeters of movement of a
test subject's
mouse cursor can be linked with brain - imaging data to discover otherwise hidden impacts on specific brain processes.
This was then
subjected to initial
testing for immunological efficacy in mThy1 - AS
mice, which overexpress WT human AS under the murine Thy1 promoter, and which exhibit sensorimotor behavioral deficits, axonal AS pathology, and C - terminally - truncated AS aggregates with regional distribution similar to PD and PD dementia (PDD).
Results showed the first two groups didn't develop PCOS, unlike the
mice in the control group, whereas the
test subjects with ovary ARs still contracted the disease, albeit at a lower rate than the normal
mice.
After exposing one group of
mice to six weeks of charged particles, the researchers
subjected them to a series of
tests.
When you're
testing on lots of
subjects — and it might benefit to study more than one generation at a time — it's hard to beat a
mouse or rat.
Analysis of exploration times during the
test revealed significant object / age interaction (P = 0.0293, 3 - way ANOVA with age and treatment as between -
subjects factors and object as within -
subjects factors), indicative of preferential exploration of the object in the novel location by the younger animals and a lack of such preferential exploration in 20 - month - old
mice.
In the study, researchers removed the ovaries of female
mice to mimic the effects of post-menopausal women before implanting estrogen - receptor positive cancer tumors into the
test subjects.
The second section is on
mice which, while decent
test subjects, are obviously not identical to humans.
In a study involving dietary ketosis via a low carbohydrate diet (less than 10 percent of total calories), compared to
subjects on a 50 percent carbohydrate diet, the low - carbohydrate
subjects demonstrated better performance on memory
tests, with higher scores being correlated to higher serum KB levels.14 A study using cultured
mouse hippocampal cells showed that addition of the KB β - hydroxybutyrate (β - OHB) to cells exposed to Aβ resulted in no decrease in the numbers of dendrites or total neurons — two of the noted pathological changes in AD.