Sentences with phrase «mice used in the study»

Daniel Peterson, an immunologist at Johns Hopkins Medical Institute in Baltimore, Md., says that the study has limitations because no human — no matter how dirt averse — could be as germ - free as the mice used in the study.

Instead, some suggested that the knockout strain of mice used in the study were especially prone to cancer.

We are very grateful to Dr. Peter C. Butler (University of California, Los Angeles, Los Angeles, CA) for supplying the colony of Tg - hIAPP mice used in this study and for providing advice in various aspects of IAPP and diabetes research.

Mice used in this study were in a 129Ola / C57BL6 mixed background unless noted differently.

And they still have to discover and test drugs that can do this for natural - born adult humans; the mice used in this study were genetically engineered.

Correspondingly, endothelial - specific deletion of Tie2 using Ve - cad - Cre driver mice, pursued in validating the Tie2fl / fl mice used in this study, essentially phenocopied the global Tie2 KO phenotype with embryonic lethality around E10.5 (Supplementary Fig. 13), confirming the key role of endothelial Tie2 during embryonic development.

In addition, Zhang and colleagues observed that soluble Aβ is responsible for learning and memory deficits in the huAPP / PS1 mice used in these studies [46].

A photo of mice used in this study is available at http://www.ninds.nih.gov/img/mice.htm.

Even the mice used in the study had fur changes when the PAD13 or TGM3 genes were defective.

We were unable to confirm the anti-inflammatory effects of exercise in the frontal cortex using inflammatory gene expression, as the Grn − / − mice used in this study (∼ 8 months when brains were collected) were not old enough to manifest these changes, which become prominent around 1 year of age (Ahmed et al., 2010; Wils et al., 2012).

DJ - 1 + / −; PolgWT / MT mice were then bred with each other to produce the cohorts of mice used in this study.

A, Double heterozygous mice were bred to generate the four genotypes of mice used in this study.

Not exact matches

While we can't use sterile mice to make any definitive conclusions about humans, the twins study, published in the journal Science last year, provided clear evidence that the microbiome is involved in weight gain — something earlier research had only suggested.

One study found brain hemorrhages in mouse fetuses exposed to pulsed ultrasound at doses similar to those used on human babies.

While our work has used mouse models because we can study the process in detail this way, we do know that milk cells cross into human babies as well.»

In a study in the journal Science, researchers explain how they used mouse embryonic stem cells and microchip technology to create heart muscle tissue that actually beatIn a study in the journal Science, researchers explain how they used mouse embryonic stem cells and microchip technology to create heart muscle tissue that actually beatin the journal Science, researchers explain how they used mouse embryonic stem cells and microchip technology to create heart muscle tissue that actually beats.

The researchers used two genetic lines of mice in the study to focus on AHR.

The researchers are planning to use the novel mouse model to study how ErbB4 may coordinate brain activities, in an effort to learn more about mechanisms behind attention deficit disorders.

In a study published earlier this year, his team, along with scientists at Arcturus Therapeutics, treated hemophilia in mice using mRNA that encodes a clotting proteiIn a study published earlier this year, his team, along with scientists at Arcturus Therapeutics, treated hemophilia in mice using mRNA that encodes a clotting proteiin mice using mRNA that encodes a clotting protein.

Jiang said autism researchers worldwide could use the mouse model to study ways to compensate for the gene and improve symptoms in people with autism spectrum disorders and Phelan - McDermid Syndrome, a more profound developmental condition caused by mutations to SHANK3 and other genes in chromosome 22.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

In this study, Dr. Dimitriou monitored spindle signals in humans while they learned to control the position of a visual cursor by moving their hand (much like using a computer mouseIn this study, Dr. Dimitriou monitored spindle signals in humans while they learned to control the position of a visual cursor by moving their hand (much like using a computer mousein humans while they learned to control the position of a visual cursor by moving their hand (much like using a computer mouse).

While the study used mice, COUP - TFII probably works the same way in other mammals, including humans, Donahoe says.

They studied the bone metabolism at the cellular level using advanced imaging and computational techniques, which allowed them to identify 142 metabolites that were significantly altered by more than 1.5 times in the diabetic mice.

Ellen Heber - Katz, a scientist at The Wistar Institute in Philadelphia, used to study autoimmunity — that was until she noticed something strange in the mice she was using to model lupus: The small holes that she had poked in their ears to distinguish the animals from one another kept closing.

Since then, Pereira - Smith's team has moved into using genetic techniques in mice to study whether and how senescence is regulated by MORF4 and related genes.

In a previous study Hu's research team used neuron - disrupting molecules to prove the relationship between dmPFC activity and a mouse's decision to surrender to or push back against its cage mate in the tube tasIn a previous study Hu's research team used neuron - disrupting molecules to prove the relationship between dmPFC activity and a mouse's decision to surrender to or push back against its cage mate in the tube tasin the tube task.

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.

In this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumorIn this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumorin Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumors.

Dr. Erez and her team used mouse models to study and follow the spontaneous metastasis of melanoma in the brain.

This is an image of neurons in the somatosensory cortex of mouse models of epilepsy used in the study.

So from our study using mice, the correct time to eat more would be earlier in the day.»

Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of at least a third of all myeloma cases.

Experiments with a compound called TNP [N2 -(m - Trifluorobenzyl), N6 -(p - nitrobenzyl) purine], which researchers often use to study obesity and diabetes, show that in mice the therapy can promote the formation of new bone.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune systeIn this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune systein order to reconstruct elements of the human immune system.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

Different types of studies use different stand - ins: Flies for genetics; zebrafish for early development; rats and mice and monkeys for cancer, neuroscience and more.

The new study, using an experimental mouse model of diabetes, is published online in the journal PLOS One.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxiIn a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxiin the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxiin collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxiin mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.

In their study, Stephanie Cherqui, PhD, associate professor in the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weaknesIn their study, Stephanie Cherqui, PhD, associate professor in the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weaknesin the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weakness.

In this study, the researchers used two groups of mice with different types of colitis, chronic and acute.

Now, in a provocative study that raises unsettling questions about the widespread use of vitamin supplements, Swedish researchers have showed that relatively low doses of antioxidants spur the growth of early lung tumors in cancer - prone mice, perhaps by hindering a well - known tumor suppressor gene.

Zhao and colleagues used mice to study serotonin's role in the skin.

Preliminary results from his latest mouse studies show that an herb used in traditional Chinese medicine supplies a microRNA that combats the flu virus in the lungs.

In the study, the researchers used electrical pulse to permeate Cpf1 RNPs into up to 50 mouse embryos simultaneously (Fig. 3b).

All animals use the same enzyme to create the same methylation mark as a signal for gene repression, and her colleagues who study epigenetics in mice and humans are excited about the new findings, Strome said.

Nakajima defends his group's methodo logy, stating that they adopted a strategy similar to that commonly used in studying autoimmune encephalitis in mice.

«It also remains to be elucidated whether this phenomenon is particular for the mouse strain used in this study or is a more general phenomenon that also occurs in other genetic strains,» said Dr. Gerjo JVM van Osch, senior author of the Journal of Orthopedic Research article.