Sentences with phrase «mice with abnormalities»

The new drug, in its time - release coating, was tested in mice with abnormalities similar to those experienced by people with neovascular age - related macular degeneration, or «wet» AMD.

Not exact matches

Depending on results from further behavioural studies in mice and humans, the abnormalities could then be treated in parallel with seizures.

«We plan to evaluate whether the abnormalities we found are associated with deficits in attention in these and other mouse models.

In addition, we plan to treat these mice with standard treatments for attention deficit disorder such as Ritalin and determine whether the behaviour and the EEG abnormalities can be corrected».

Researchers at Weill Cornell Medical College recently identified a gene abnormality that is associated with anxiety - related behaviors; it makes humans and mice hypervigilant to cues that signal danger.

Because hair cells are also critical for the sense of balance, mice with damaged or missing hair cells show balance abnormalities.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Now, in the first report on the effects of erasing a single microRNA in a vertebrate, scientists describe mice with subtle but profound heart abnormalities.

The fact that mice missing Arp2 / 3, and also showing motor abnormalities, seemed to get better with the antipsychotic drug haloperidol suggested that they have too much dopamine in their brains.

In the new study, Soderling, postdoctoral researcher Il Hwan Kim, and their team characterized three brain abnormalities in the Arp2 / 3 mice that also appear in people with schizophrenia.

The mice also displayed features consistent with autism spectrum disorder, such as social interaction abnormalities, repetitive behaviors, and abnormal «squeaks» or vocalizations.

Wang went on to probe the mechanisms behind these cardiac abnormalities, striking up a collaboration with Jeffrey Esko, a biologist at UC San Diego who had engineered mice that model MPS.

Verma is quick to point out that although there have been two case studies in which BRCA1 mutations were linked to brain abnormalities, the dramatic effects documented in the mice in the study are unlikely to occur in women with a BRCA1 mutation, who still have some functioning BRCA1, compared with the mice who had none at all.

A team of neuroscientists has identified a protein in laboratory mice linked to impairments similar to those afflicted with Angelman syndrome (AS)-- a condition associated with symptoms that include autism, intellectual disability, and motor abnormalities.

The researchers tested the mice for abnormalities in reward - learning behavior — learning to associate actions with rewarding outcomes.

Antipsychotic medications, a mainstay of treatment for schizophrenia, alleviated some of the animals» symptoms.In the new study, Soderling, postdoctoral researcher Il Hwan Kim, and their team characterized three brain abnormalities in the Arp2 / 3 mice that also appear in people with schizophrenia.

These abnormalities were not observed during the time of our experiments in Tg - hIAPP untreated mice or mice injected with pancreas homogenate without IAPP aggregates.

A new Duke University study in mice links three previous and, until now, apparently unrelated hypotheses about the causes of schizophrenia, a debilitating mental disorder appearing in late adolescence that affects how people think, act and perceive reality.The brains of people with the schizophrenia show various abnormalities, including faulty neural connections or an imbalance of certain brain chemicals.

The bacteria associated with the 3D surface will colonize that mouse, and reduce certain abnormalities that we see in that mouse, such as an allergy response.

Our findings first confirmed previous work with this model in demonstrating that compared to undefeated control animals, mice most susceptible to social defeat stress demonstrated a number of abnormalities in social avoidance, depression and anxiety as measured by routine test procedures.

It is unfortunate that the investigators did not assess insulin secretion, insulin action, or systemic inflammation in early - aging BubR1H / H; INK - ATTAC mice, with and without ablation of senescent adipose cells, but reasonable to be optimistic that doing so would yield some normalization of age - related metabolic abnormalities.

Both Drosophila and mouse models with centrosome dysfunction showed abnormalities in the neuroepithelium reminiscent of the ones described in brains of human patients.

Francesco Longo is interested in understanding the synaptic and behavioral abnormalities associated with autism spectrum disorder, with particular attention to striatal dysfunction in fragile X syndrome model mice.

A new study shows that increasing the activity a critical piece of machinery called «mTORC1» in a mouse model of Huntington's disease leads to improved motor problems and brain abnormalities associated with the disease.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

Howard Hughes Medical Institute researchers have produced a genetically altered mouse that exhibits behavioral abnormalities that are strikingly similar to those observed in humans with schizophrenia...

In previous studies, TERT - / - mice have been generated on either a C57BL / 6J or a 129 / C57BL / 6J mixed genetic background strain, both of which have «very heterogeneous and unusually long telomeres,» again raising the possibility that any developmental abnormalities might be due to subpopulations of stem cells with critically - short telomeres.

It is known that motor abnormalities in CAG 94 KI and CAG 140 KI mouse models are present from an early age, with a delayed onset observed in the CAG 94 KI model as compared to CAG 140 KI; in addition, overt behavioral deficits were observed after 2 years of age in the CAG 140 KI mouse model (Menalled et al., 2003, Hickey et al., 2008).

Finally, and possibly most importantly this study doesn't explain ANY of the metabolic effects so strongly linked to PCOS, as giving a massive injection of AMH to the pregnant mice still did NOT induce any of the metabolic abnormalities or insulin resistance that are so characteristic of the vast majority of women with the condition.

In the initial report, mice harboring a mutation in the core circadian gene Clock (termed Clock mutant mice) were fed a high - fat (HF) diet and observed to develop obesity at a young age, as well as a variety of metabolic and endocrine abnormalities consistent with the metabolic syndrome (2).

A study that exposed mice to fluoride and subsequently treated them with GABA showed improved results for T4, T3 and thyroid hormone - binding globulin (TBG levels) along with healing of the structural abnormalities in thyroid follicles that were observed after fluoride exposure.

The fluoride - exposed mice that were subsequently treated with GABA were found to have improved results for T4, T3 and thyroid hormone - binding globulin (TBG levels) and healing of the structural abnormalities in thyroid follicles that were observed after fluoride exposure.