Sentences with phrase «mice with cocaine»

Not exact matches

In one experiment, they placed mice in a cage with two rooms, and trained them to expect occasional doses of cocaine in one of the rooms.

Using mice, they found that cocaine induces NO to react with GAPDH so that GAPDH moves into the nucleus.

Blakely's team, led by postdoctoral fellow Linda Simmler, Ph.D., found that the stimulant actions of cocaine were preserved in the genetically - modified mice, consistent with these actions being driven by dopamine elevations.

The increase in electricity — and thus the presumed sensitivity of the mouse to cocaine — lined up perfectly with the rate at which the mice ran around the track.

But when mice were injected with cocaine and also treated with halorhodopsins and light — in this case a yellow pulse sent directly to the brain's reward center — the rush of euphoria was blocked.

Working with mice, researchers at Johns Hopkins have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally digest their own insides.

Mice were injected with cocaine and placed into one of two compartments of a cage to learn to associate cocaine with the smell, feel and look of that location.

By contrast, mice who were not intellectually challenged and / or whose activities and diets were restricted, were eager to return to the quarters where they had been injected with cocaine for weeks on end.

With repeated exposure to the caffeinated alcohol, those adolescent mice became increasingly more active, much like mice given cocaine.

With the combined use of genetics and pharmacology, the investigators altered the production of proteins controlled by eIF2α in adult mice, essentially converting them into adolescents by making them more susceptible to cocaine - induced changes in synaptic strength and behavior.

In the first study, the team injected adolescent and adult mice with saline or a low dose of cocaine.

Conversely, adolescent mice with increased eIF2α activity in the brain became more resistant to the effects of cocaine, as seen in adults.

For the second paper, the team carried out similar experiments in mice with different doses of nicotine instead of cocaine, showing that the same effects are also true for this drug.

But when those high levels of caffeine were mixed with alcohol and given to adolescent mice, they showed physical and neurochemical signs similar to mice given cocaine.

The George lab has made seminal contributions to the field including: discovering a novel population of neurons in the brain of humans, rats and mice that are involved in nicotine dependence, identifying neuronal ensembles responsible for nicotine and alcohol addiction, and unveiled the cellular and molecular changes associates with long term use of nicotine, cocaine, methamphetamine and alcohol use on the brain.

When the researchers added cocaine to injured mouse brains, they found that male mice with concussions had more dopamine building up in between cells than did females or non-injured mice.

In fact, some of the more prominent animal studies show that sugar is eight times more addictive than cocaine: one in particular went on to show that mice react to Oreo cookies with the same addictive behavior as they do with specific drugs.