Sentences with phrase «mice with earlier stage»

They found that levels of an enzyme involved in ketone metabolism, known as BDH1, were twice as high in mice with both early stage and complete heart failure compared to normal animals.

Not exact matches

When his team looked at gene expression changes in the mice, then applied them to humans with early stage cancer, the results revealed a breakdown of which patients have a high or low chance of survival.

But little is known about the early developmental stages of human gametes — owing to the sensitivity of working with human tissue — and most work in this area has been conducted using mice.

In a final set of experiments, the researchers used necrostatin - 1 to treat mice with axonal damage and hind leg weakness, a telltale sign of axonal demise similar to the muscle weakness that occurs in the early stages of ALS in humans.

But in APOE4 or APOE3 mice with earlier - stage AD, the amount of soluble amyloid - beta actually increased.

After 11 weeks, the mice fed with artificial sweeteners showed an unusually high spike in blood glucose levels when given a glucose meal, a condition called glucose intolerance that is seen as an early stage in the development of diabetes.

LaDu, working with Leon Tai, research assistant professor in anatomy and cell biology, and their coworkersgave bexarotene to mice carrying APOE4 or APOE3 for seven days during the early, intermediate, or late stages of AD.

The drug, bexarotene, was found to reduce levels of the neurotoxic protein amyloid - beta in experimental mice with late - stage Alzheimer's but to increase levels during early stages of disease.

His lab is now investigating what happens in the earliest stages of the development of mice with the autism - related Shank3 mutation, and whether any of those effects can be reversed either during development or later in life.

Scientists at Georgia State University (GSU) with funding from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have designed an imaging technique to detect early - stage liver tumors, and have proven it successful in mice.

In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer's.

In summary, we demonstrate similar neurological / motor function deficits in SOD1 and PFN1 mice, both exhibiting clinically - relevant attributes of Amyotrophic lateral sclerosis (ALS), with more advanced computer vision systems identifying distinctive behavioral patterns and discriminating the phenotype at very early disease stages in both models.

This strain showed a highly virulent phenotype, with rapid multiplication during the early stage of infection in a murine model of TB with excessive lung inflammation, and infection with this strain resulted in more rapid death of mice than infection with the reference H37Rv strain.

LaDu, working with Leon Tai, research assistant professor in anatomy and cell biology, and their coworkers gave bexarotene to mice carrying APOE4 or APOE3 for seven days during the early, intermediate, or late stages of AD.