Sentences with phrase «mice with the rodent»

Virgin first infected mice with the rodent equivalent of these two herpes strains and then exposed them to two types of bacteria: Listeria monocytogenes, a common cause of food poisoning, and Yersinia pestis, which causes bubonic plague.

So the team engineered a mouse model that gradually lost the enzyme as it grew older and then bred those mice with rodents that were engineered to develop amyloid plaques from an age of 75 days.

Not exact matches

A review of the farm's pest control records flagged an ongoing rodent infestation, with rodents, dead carcasses and baby mice observed, along with workers who weren't following proper sanitary practices.

For all the human - mouse mixing, however, the rodents were no better learners than those with mouse - only brains.

They started with pairs of fat yellow mice known to scientists as agouti mice, so called because they carry a particular gene — the agouti gene — that in addition to making the rodents ravenous and yellow renders them prone to cancer and diabetes.

An inflammatory protein that triggers a pregnant mouse's immune response to an infection or other disease appears to cause brain injury in her fetus, but not the premature birth that was long believed to be linked with such neurologic damage in both rodents and humans, new Johns Hopkins - led research suggests.

This summer Wagers published research [subscription required] showing that when muscle stem cells were transferred into mice with a type of muscular dystrophy, the rodents» muscle function improved.

Working with mice, researchers at Vanderbilt University in Nashville have found that rodents are more sensitive to insulin's effects at certain times of day.

As rodents prefer to spend more time with novel objects than familiar ones, the researchers first exposed the mice to two identical objects (cones or pyramids, in either black or white).

While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.

As rodents prefer to spend more time with novel objects than familiar ones, the researchers first exposed the mice to two identical objects for habituation (cones or pyramids) and later measured the animals attention towards a novel object with different shape.

During studies with mice, he concluded that female rodents were more anxious when their hormone levels mirrored those of premenstrual women.

Frustrated, Christiano turned to a colleague, who suggested she look at a lanceolate mouse, a rodent with sparse, stubbly hairs but no identified mutation.

So far, they have worked with only small laboratory rodents — mice and rats.

Then they injected the rodents» brains with Salmonella bacteria to cause an infection and waited to see whether the mice making the extra amyloid did better than controls at fighting off the microbes.

After two months, the rodents can lift 30 percent more weight, and their muscle mass has swollen by a third — double what his control group of mice (those without IGF - I) can achieve with weight training alone.

Charged with finding a new remedy for malaria, scientists working for Mao Tse - tung and Chou En - lai decided to test Ge Hang's ancient wormwood recipe in mice infected with a malarial strain that is lethal in rodents.

The livers of the engineered mice were covered in lesions after 10 weeks, and only half of the animals lived longer than that, compared with more than six months for the unmodified rodents.

In rodents, differences in life expectancy and morbidity during aging are particularly high: Despite close relationships with regard to genetic aspects, small rodents like mice or rats live no longer than two to three years, whereas mole - rats or chinchillas have an average life span of 20 to 30 years while staying comparatively healthy.

Changes in muscle repair with aging were determined by injecting the old mice and young mice (neither group exercised) with snake venom commonly used to induce muscle injury in rodent studies.

Chronically treating mice with an antidepressant, fluoxetine, and raising rodents in a stimulating environment with toys and plenty of social interaction, are among other paradigms that do the same.

You would create a mouse model of attention deficit / hyperactivity disorder (ADHD) or depression and dose the rodent with molecules carefully designed to close one cell receptor or open another.

They used genetic knockout mice to look for the cells, silencing different types of TRCs, then flushing the rodents» mouths with water to see which cells responded.

But for all Dawson's frustration with mice, the rodents did yield a couple of interesting drug leads.

Mice injected with a virus genetically altered to help the rodents create an antibody designed to fight the malaria parasite produced high levels of the anti-malaria antibody.

As the mice developed, Verma's team found that the rodents» brains were only a third of their normal size, with particularly striking reductions in brain areas involved in learning and memory.

During the stress period, half of the mouse mothers (control and early - life stress) received a standard rodent diet, the other half received a diet that was supplemented with essential micronutrients.

Twenty - four hours after the injection, the researchers saw large numbers of immune system white blood cells in tissue samples of the rodent brains near the site of injury of those mice injected with the cytokine IL - 1b, but not in the brain tissue of the control group of mice.

It was one of the most mind - bending scientific reports in 2014: Injecting old mice with the plasma portion of blood from young mice seemed to improve the elderly rodents» memory and ability to learn.

A newly discovered hormone in mice prompts the rodents to boost their production of pancreatic β cells, the ones that make insulin and are missing or not productive enough in patients with diabetes.

Pulsing blue light upon the mice for 48 hours led to an increase in the rodents» insulin levels and better tolerance of glucose compared with control mice.

To Mayford, this suggests that when the mice got the drug in the first round of the experiment, it caused a bland memory to be muddled with a bad one, thereby hampering the rodents» ability to learn.

And when the researchers gave mice manganese and then injected them with shiga toxin, all of the rodents survived.

For four weeks, the researchers fed mice either a grain - based rodent chow, a high - fat diet (high fat and low fiber content with 5 percent cellulose as a source of fiber) or a high - fat diet supplemented with fiber (either fermentable inulin fiber or insoluble cellulose fiber).

Yet when Evans and his colleagues recently gave a PPAR & # 948 - boosting drug to normal adult mice, the rodents developed no greater stamina than nondoped counterparts — until the researchers had the animals combine the drug with a workout routine.

The SNRK - lacking mice maintained their extra weight even when treated with a drug known to induce weight loss in rodents by activating brown fat.

A team led by parasitologist Stefan Kappe at the Center for Infectious Disease Research in Seattle in Washington gave a rodent version of this «genetically attenuated parasite,» or GAP, to mice and showed that they were completely protected when later infected with an unmodified — or wild - type — version of the same Plasmodium strain.

- Modelling Human Disease in Rodents with CRISPR / Cas9 Genome Editing: June 27th - Why do the results discovered using genetically engineered mice sometimes fail to translate to humans?

When the researchers administered daily doses of BCX to mice before and after they injected the rodents with a nicotine - derived carcinogen, they found that the mice treated with BCX had fewer lung tumors than those that got no BCX.

Working in mice, Norbury's team used several methods to deplete different types of innate immune cells — collectively known as myeloid cells — at the three checkpoints before infecting the rodents with poxvirus.

For their new study, scientists compared ancient mouse teeth with those of modern rodents that hang out near people who are only semi-settled.

After being injected with a muscle - preserving gene, some of these mighty rodents maintained the muscles of youthful mice, at the human equivalent of age 80, without exercise [source: Cromie].

CELPHEDIA networks aims to develop transverse inter-species approaches (rodents with the mouse as a leader, non-human primates and non mammalians including aquatic vertebrates), at the level of both the technology and the study of human diseases, but also to harmonise scientific protocols and processes.

We selected mice as the rodent species with which to prove this concept as they are a major agricultural, health and conservation pest, they are the most sophisticated animal model, and this knowledge base can be leveraged, and naturally occurring genetic elements known in mice but not other species can be exploited.

The researchers can rewrite bad memories with precision in mice, such as by switching a memory about the aforementioned yucky - tasting (to rodents) quinine water with a good memory of interacting with a desired member of the opposite sex.

In a study published in the Journal of Agriculture and Food Chemistry, mice fed a high - fat diet along with acetic acid — vinegar's key component — developed up to 10 % less body fat than control rodents.

The drug combined with the training increased the rodents» running time by 68 percent and distance by 70 percent compared with mice receiving exercise training alone.

And I bet obesity researchers who typically work with rodents would believe it, too, since peanut butter is often used in these studies as a high - reward, obesogenic comfort food that rats and mice will readily and consistently overeat.

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38

In a later study, they applied some Alzheimer's inflicted mice with 500 mg of caffeine (where do they find these poor rodents?).