Sentences with phrase «micrornas as biomarkers»

Peripheral inflammatory responses may, then, serve as biomarkers and thus serve as targets of immune - based therapies for depression.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

Objective To determine the types and frequency of rice and rice - containing products consumed by infants in the first year of life and the association with As biomarker concentrations.

While we are unaware of any prior studies relating As biomarker concentrations to rice intake among infants, associations have been observed in pregnant women in our cohort, 19 children in the National Health and Nutrition Examination Survey, 16,18 and multiple studies of adults.11 - 15

In particular, protein tyrosine phosphatase, receptor type, F (PTPRF) may serve as a biomarker linking insulin resistance with insufficient milk supply.

Human sperm may hold the potential to serve as biomarkers of the future health of newborn infants, according to a new study by a Wayne State University School of Medicine research team.

Furthermore, this can also serve as a biomarker to stratify patients for treatment.

In the future, doctors could thus use Gab2 as a biomarker and infer the course of the disease by measuring Gab2 levels.

So A1c serves as a biomarker, indicating average blood glucose levels over a two - to three - month period.

«In addition to the potential of these genes and gene products to help us design new drugs, they could also serve as biomarkers for accurate diagnosis,» she says.

The third researcher, Daniel Conklin of the University of Louisville, tracked biomarkers of exposure to new and emerging tobacco products as well as biomarkers of cardiovascular harm and injury.

Its expression could be used as a biomarker test to ensure patients might benefit from an NPTX2 inhibitor, when one is developed.

A total of 67 biochemical features discriminated cancer from benign tumors in these samples, but only four specific metabolites could be considered as biomarkers for cancer: creatinine riboside, tryptophan, Nε, Nε, Nε - trimethyllysine, and 3 - methylhistidine.

«Despite the identification of circulating tumor cells (CTCs) and cell - free DNA (cfDNA) as biomarkers capable of providing clinically relevant information in cancer patients, at present their identification is not routinely used in clinical practice,» explains Silvia Morbelli, MD, PhD, of the IRCCS San Martino — IST National Cancer Research Institute and University of Genoa in Genoa, Italy.

«Our results, and methods, could have implications for the analysis of endogenous and exogeneous compounds in the exhaled breath as biomarkers of systemic and lung diseases, as well as in development of new approaches to study human exposure to airborne contamination.»

Lin28 may serve as a biomarker for such treatment - resistant tumors.»

The authors say these sets of proteins can serve as biomarkers for monitoring autophagy in the clinical setting.

By the early 2000s, multi-stakeholder collaborations proliferated to address the need for important tools, such as biomarkers, that require preclinical data sharing.

«A retrospective analysis of the CHD1 gene in these samples may reveal the potential utility of CHD1 as a biomarker for improved prostate cancer patient stratification and targeted therapy with PARP inhibitors,» notes Johnsen.

«We have confirmed the potential of these dimers as biomarkers.

We propose that it is now feasible to validate the dimers as biomarkers for this disease,» says Carulla.

The blood samples were analyzed to measure hormone and lipid levels, as well as biomarkers of insulin resistance and inflammation.

Blood contains proteins, enzymes, lipids, metabolites, and peptides that serve as biomarkers for health screening, monitoring and diagnostics.

The technique of using sodium ions in the body as a biomarker for imaging is very challenging because of the lower detectability of the sodium signal in biological tissue by currently available MRI scanners.

The exact mechanisms must be probed in further animal studies, Reid says, but eventually he hopes researchers will be able to use a patient's bacterial makeup as a biomarker for cancer screening or to develop probiotics for improving prognosis and treatment outcomes.

«Our findings suggest that PD1could serve as a biomarker as well as a much needed antiviral drug for severe and lethal influenza virus infections,» Imai says.

Using a simple genetic test, doctors could one day use CHL1 as a biomarker to determine whether or not to prescribe SSRIs.

During the webinar, our expert panel of researchers will discuss: • Strategies and technologies for successful cancer biomarker discovery through robust detection and analysis of miRNAs in biofluids • Research into analytic and biological variables that impact miRNA measurements in serum and plasma from the clinical pathologist's point of view • The novel application of miRNAs in serum as biomarkers of aging and chronic disease • The answers to questions submitted by the live, online viewers.

Their natural characteristics make them uniquely suited for research and clinical applications, including as biomarkers both for diseases and for intrinsic biological activity.

They concentrated on organic proxies, also known as biomarkers.

The high MAO - B activity consistently observed in patients with Parkinson's disease has been proposed as a biomarker, but there has been a lack of suitable small molecule probes for MAO - B specific detection in live cells and tissues.

Furthermore, PRL - 3 has the potential to be used as a biomarker in personalised therapy for AML patients.

But in ACS Central Science, researchers reveal that an enzyme already implicated in a host of neural disorders could someday serve as a biomarker.

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

«This is how we can start thinking about precision medicine in action,» said the study's senior author, Alice S. Chen - Plotkin, MD, an assistant professor of neurology at Penn. «We found that a relatively common genetic variation can both serve as a biomarker for and influence the disease course of Parkinson's patients.

The researchers also are seeking other potential drug targets in the 50 percent of patients who don't have high levels of the anti-death protein, as well as biomarkers in addition to CA125 that could be used to screen for ovarian cancer.

Professor Moffatt said: «The genes we identified represent new potential drug targets for allergic diseases as well as biomarkers that may predict which patients will respond to existing expensive therapies.»

«This work led by Professor O'Donnell is a technical tour de force, providing a wonderful resource for other biomedical researchers,» said Mike Murphy, Ph.D., programme leader, Mitochondrial Biology Unit at Cambridge University, U.K. «A particularly important aspect is the focus on platelets, which are readily available from patients» blood in diagnosis, prognosis or as a biomarker in assessing therapies.

Previous research has shown that eye movements in response to visual stimuli can serve as a biomarker for brain states such as fatigue or high mental concentration.

In a study published in the May / June issue of mBio, an online open - access journal from the American Society of Microbiology, the researchers found that the microorganisms found in must — freshly - pressed grape juice, before fermentation — can be used as biomarkers to predict which metabolites will be found in the finished wine.

In one VA - funded study, he is using a type of electroencephalography (EEG)-- in which veterans wear an electrode - studded cap on their head — to trace brain patterns that may eventually serve as biomarkers.

The findings, which appear in the journal Alzheimer and Dementia, point to new biological pathways that may be implicated in AD and could serve as biomarkers for risk of the disease.

These macrophage - derived mediators may have potential as biomarkers to reflect the urinary stone risk, according to a new study from Japan, which was recently presented at the recent 2nd Meeting of the EAU Section of Urolithiasis and received Clinical Research Award.

«The findings advance our understanding of the role of lncRNAs in cancer biology and, importantly, broaden the opportunity to use lncRNAs as biomarkers to detect prostate cancer.»

«Furthermore, the insulin - specific TFH cells could serve as biomarkers to determine the treatment success of the insulin vaccinations we perform.»

«This suggests that using epigenetics as a biomarker could give you a lot of information about environmental exposures within particular populations that's not captured by genetics,» Zaitlen said.

«Triple - negative breast cancer continues to be a severe health problem, demanding the consideration of emerging long non-coding RNAs as biomarkers and therapeutic targets in combatting this disease,» said Liquing Yang, Ph.D., assistant professor in the Department of Molecular & Cellular Oncology.

These EVs have been recognized as messengers of cell - to - cell communication and as biomarkers for various diseases.

«This way,» he says, «we can start to evaluate the use of various compounds as biomarkers and indicators of patient recovery.»

«This is, however, an important pre-requisite in order to detect proteins as biomarkers, i.e. as indicators of certain diseases, or new drug targets.»