The CDI HuProt
microarray contains nearly 75 % of the human proteome on a single glass slide, a unique and powerful tool for high - throughput serum profiling and biomarker discovery.
As
the microarray contains a diversity of genes originated from different organisms, all genes were transformed to Homo sapiens ones.
The Virochip, a pan-viral
microarray containing ∼ 19,000 probes derived from all viral species in GenBank (n ∼ 2500)[21], [23], has been previously successful in detection of novel outbreak viruses such as the SARS coronavirus [22], [24] and the 2009 pandemic H1N1 influenza virus [23].
While
some microarrays contain distant sites, these often are not available from the same patient.
In addition to analysis using the full HuProt microarray, CDI can custom print
microarrays containing up to 14 separate subarrays - each containing only proteins of interest as determined during the discovery phase.
Not exact matches
DNA
microarrays consist of thousands of spots
contained on a single 1 x 3 inch glass slide, each spot representing a different gene.
For instance, the National Center for Biotechnology Information's public repository of gene - expression data, GEO, now
contains 392,000
microarray experiments.
CDI has produced the ZikaProt ZIKV / DENV protein
microarray which
contains the proteomes of Asian and African strains of Zika as well as dengue serotypes 1 and 2.
Using a specialized DNA array
containing thousands of Arabidopsis genes (an EST
microarray), the researchers then analyzed gene expression in their mutant and quickly found that MPK4 somehow controls the expression of anti-microbial genes of the SAR response.
We can make cell
microarrays that
contain a very large percentage of the human genome without being limited by the protein's properties,» says Sabatini.
B. Heatmap depicts normalized intensities of
microarray probes
contained in promoters (at most one per promoter) that best differentiate between CPA and control groups.