Not exact matches
«I think it's important [
for journals] to be discussing this, but I think it's unrealistic to think that journals can and should play the role of the sole enforcer,» says Claire Fraser, director of The Institute
for Genomic Research in Rockville, Maryland, which posts a range of
microbial gene sequences online.
These drug - bug interactions could make
microbial genes just as important as a person's
genes for predicting how a drug will affect someone, says Matthew Redinbo of the University of North Carolina at Chapel Hill.
High in the Cederberg Mountains of South Africa grows a bristly shrub that embodies the tug - of - war taking place between industrialized and developing nations over the value of genetic resources — the
genes found in plant, animal or
microbial cells used
for research as well as in commercial products, such as enhanced seeds and naturally derived cosmetics and pharmaceuticals.
When it comes time
for microbial gene swapping, anything goes.
In a study to be presented on Feb. 5 at the Society
for Maternal - Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in Atlanta, researchers will present findings from a study titled, Maternal Diet Alters the Breast Milk Microbiome and
Microbial Gene Content.
The
microbial mass in and on a person may amount to just a few pounds, but in terms of genetic diversity these fellow travelers overwhelm their hosts, with 400
genes for every human one.
The team's next goal was to transfer the
genes for making gas vesicles from the water - dwelling bacteria into a different type of bacteria — Escherichia coli, which is commonly used in
microbial therapeutics, such as probiotics.
They sent soil samples
for DNA testing, looking
for matches with particular
genes known to be found in microbes and fungi; they tried to stimulate
microbial growth on a wide variety of substances and then count the cells produced; and they used highly sensitive radiorespiration activity assays, which involve feeding the soil microorganisms a food source which has been labelled with radioactive carbon, which can then be used to detect if the microorganisms are active.
For instance, the Human Microbiome Project (HMP)(Turnbaugh et al, 2007; Peterson et al, 2009; Huttenhower et al, 2012) and MetaHIT (Qin et al, 2010) have generated maps of bacterial species abundances throughout the human body, reference genomes, and catalogs of more than 100 million
microbial genes assembled from shotgun sequencing of in vivo communities.
$ 2,500 «Beyond bacteria» Deeper shotgun metagenome and virome characterization of one sample, plus additional marker
gene sequencing (16S rRNA, 18S rRNA and ITS,
for you sequencing wonks) to characterize not just the bacteria but also the viruses,
microbial eukaryotes (like giardia), and fungi in your gut.
E. coli has been our main
microbial bacterial workhorse
for 100 years, and we still don't know what one - third of the
genes do.
«The
microbial fuel cell could power lights
for a full - size tree — we just don't have the room
for that,» says Haluk Beyenal, associate professor in the
Gene and Linda Voiland School of Chemical Engineering and Bioengineering.
He teamed with Dr. Janeway in the search
for the
gene in the innate immune system that activates the adaptive system — to address the questions, how does the human body know when it has an infection, and how does a
microbial infection trigger an immune response?
«
For example, we want to establish benchmarks for which types of genes and which profiles in specific microbial communities may be of concern and assign relative ranking criteria to inform future testing and monitoring.&raq
For example, we want to establish benchmarks
for which types of genes and which profiles in specific microbial communities may be of concern and assign relative ranking criteria to inform future testing and monitoring.&raq
for which types of
genes and which profiles in specific
microbial communities may be of concern and assign relative ranking criteria to inform future testing and monitoring.»
VITCOMIC2: visualization tool
for the phylogenetic composition of
microbial communities based on 16S rRNA
gene amplicons and metagenomic shotgun sequencing — Hiroshi Mori — BMC Systems Biology
Other uses of having a known link between multiple DNA sequencing reads includes studies of structural variations in
for instance cancer cells, and when linking functional
genes to taxonomic groups in
microbial communities.
Assigning 16S rRNA
gene sequences to operational taxonomic units (OTUs) allows
microbial ecologists to overcome the inconsistencies and biases within bacterial taxonomy and provides a strategy
for clustering similar sequences that do not have representatives in a reference database.
ZIG differential abundance detection method accounts
for bias introduced by the under - sampling of
microbial communities commonly found in large - scale marker
gene studies.
Computer simulations by Liu et al. [43], Wang et al. [41], and Sundquist et al. [47] have indicated that pyrosequencing tags from different regions of the
gene will vary in their utility
for the distinct tasks of revealing
microbial diversity and performing taxonomic classification, both of which contribute to making informative comparisons between complex
microbial communities.