Sentences with phrase «microbial genome»

«Even though a microbial genome is one - thousandth the size of the human genome, the total number of microbial genes in [the human] body is much greater than human genes because you have so many different species,» says Weinstock.

Microbial genome sequencing promises much, but many barriers exist to its routine deployment.

They helped reveal the transcription start sites and antisense transcripts of microbial species, improving the microbial genome annotation.

The sequencing of M. jannaschii was funded by the US Department of Energy (DOE)'s Microbial Genome Project, which, since 1994, has investigated microbes that might be useful in environmental cleanup, energy production, or other aspects of DOE's mission.

Having obtained my PhD degree in Microbiology at Wageningen University (The Netherlands) I moved to Sweden with my family to work at Uppsala University to focus on microbial genome evolution.

A few interesting articles in early life human microbiome, plus: A comparison between Staphylococcus epidermidis commensal and pathogenic lineages from the skin of healthy individuals living in North American and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs) from their genome sequence; The seasonal changes in Amazon rainforest soil microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather microbiome; chronic stress alters gut microbiota and triggers a specific immune response in a mouse model of colitis; and evidence that the short chain fatty acids profile in the gut reflects the impact of dietary fibre on the microbiome using the PolyFermS continuous intestinal fermentation model.

«We knew we could boot up a virus from our synthetic DNA, but nobody had ever transplanted a microbial genome, specifically one made from scratch with four bottles of chemicals,» Venter told The Washington Post.

The meeting will focus on DNA transfer and genome repair and consequences for microbial genome instability, fitness for survival and virulence.

A team of scientists announced that they have sequenced the genome of the common soil bacterium Streptomyces coelicolor — the largest microbial genome to date — unearthing both promising and surprising genomic features.

At roughly 48,000 years old, it's the oldest microbial genome sequenced, the researchers report.

Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously sequenced microbial genomes.

Putman then extended Wikidata with a focus on microbial genomes.

In a global culture increasingly driven by scientific and technological innovation, research in areas ranging from microbial genomes to the human brain will become ever more inextricably linked to public health, medicine, and industry.

The sorter scoured public databases of sequenced microbial genomes, looking for fragments of genomes that resembled virus genomes that had already been sequenced — for starters.

Now, an extensive analysis of microbial genomes suggests that more than half of bacteria home in on chemical cues to reach a target, an ability called chemotaxis.

That's unusual; most microbial genomes consist of a single chromosome, sometimes with some extra genes carried on bits of extraneous DNA called plasmids.

Even without an immediate pay - off, TIGR says the project provided experience in comparing microbial genomes that could be useful in future outbreaks.

The studies open up new opportunities to uncover microbial genomes from other environments, revealing how microbes alter global carbon and nitrogen cycles, how microbial metabolism evolved, and how so many different kinds of microbes can coexist, says biological oceanographer Paul Falkowski of Rutgers University in New Brunswick, New Jersey.

The Streptococcus pneumoniae Genome Diversity Project More information about S. pneumoniae, on a site supported by vaccine manufacturer Wyeth - Lederle List of the more than 45 microbial genomes so far completed, with links to others still in progress

The genome contains 3 to 4 times more DNA than other microbial genomes sequenced so far, and it's chock full of useful genes with relatively little useless DNA in the way.

«Mining sequence data in DOE JGI's Integrated Microbial Genomes & Microbiomes system, which houses thousands of metagenomes, allowed us to find evolutionary relatives of our Klosneuvirus,» Schulz said.

They found that the microbial genomes from some patients differed widely from one another, just as you'd expect with environmental infections.

The objectives of this initial work are to sequence the genomes of 200 microbes that have been isolated from the human body as part of the 1,000 microbial genomes collection.

Ecological selection for small microbial genomes along a temperate - to - thermal soil gradient — Jackson W Sorensen — bioRxiv

Venter, who pioneered the sequencing of microbial genomes, estimated that 50 to 100 more genomes needed to be sequenced to help triangulate back to the last common ancestor.

A Sanger / pyrosequencing hybrid approach for the generation of high - quality draft assemblies of marine microbial genomes.

Other microbial genomes are being contributed to the collection by individual NIH institutes and internationally funded projects.

Conclusions We described NaS tool, a hybrid approach allowing the sequencing of microbial genomes using the MinION ® device.

Learning more about this so - called «microbial dark matter» involves extracting microbial genomes from the amplified DNA of single cells and from metagenomes.

Pseudomonas Genome Database: facilitating user - friendly, comprehensive comparisons of microbial genomes.

Lecture 4: Replication - strand specific oligomer bias in bacterial genomes Coffee break Methods to Compare Microbial Genomes Lecture 5: 20 Methods to Compare Microbial Genomes

An ensemble strategy that significantly improves de novo assembly of microbial genomes from metagenomic next - generation sequencing data.

XtalPred provides: (1) a detailed comparison of the protein's features to the corresponding distribution from TargetDB; (2) a summary of protein features and predictions that indicate problems that are likely to be encountered during protein crystallization; (3) prediction of ligands; and (4)(optional) lists of close homologs from complete microbial genomes that are more likely to crystallize.

With the number of published microbial genomes now in excess of 100, any new genome that is sequenced is likely to have a close relative available for comparison.

Not exact matches

They identified microbial genes and their activity with help from DOE's Joint Genome Institute in Walnut Creek CA.

The result was an extremely high - throughput sequencing protocol that, in a single run, can cover portions of the genomes of over 50,000 microbial cells (2).

Efforts to obtain and study genomes and enrichment cultures of uncultivated microbial lineages will likely further expand our knowledge about archaeal phylogenetic and metabolic diversity and their cell biology and ecological function.

«Knowing which microbes live in various ecological niches in healthy people allows us to better investigate what goes awry in diseases thought to have a microbial link, like Crohn's disease and obesity,» says George Weinstock, associate director of the Genome Institute at Washington University in St Louis and one of the Human Microbiome Project's principal investigators.

In a perspective piece published November 6 in the journal Science, Eddy Rubin, Director of the U.S. Department of Energy Joint Genome Institute (DOE JGI), a DOE Office of Science User Facility, along with Microbial Program Head Tanja Woyke, discusses why the time is right to apply genomic technologies to discover new life on Earth.

But the genome sequences revealed in this study suggest that there are many more prophage - like viruses that are different in one important respect: Their genome remains separate from their microbial hosts» genome.

The genome data give both cholera researchers and microbial ecologists a new way to look at the microbe.

Biotech guru J. Craig Venter proposes that if we find microbial life on Mars, we could sequence its genome locally, transmit the information and rebuild the organism here on Earth.

Powered by the synthetic genome, that microbial cell began replicating and making a new set of proteins.

Their microbial exposures varied and gene expression patterns varied, but the parts of the genome that were open at each location in the gut remained consistent, Crawford said.

A team led by Jose García - Bustos of GlaxoSmithKline's molecular microbiology division in Tres Cantos, Spain, published the annotated but incomplete genome of a virulent, antibiotic - resistant S. pneumoniae strain in the June issue of Microbial Drug Resistance.

We have applied «whole - genome shotgun sequencing» to microbial populations collected en masse on tangential flow and impact filters from seawater samples collected from the Sargasso Sea near Bermuda.

The Rush team brought the samples to U-M's Center for Microbial Systems for sequencing, and Snitkin's team started to put the genome data together with what Hayden's team had found out about the outbreak.

For example, the large - scale sequencing program has already started to sequence the genomes of 100 microorganisms found in the human gut, and will build on this by using genomic sequencing to characterize the complex microbial communities found at many sites in and on the human body.

For instance, the Human Microbiome Project (HMP)(Turnbaugh et al, 2007; Peterson et al, 2009; Huttenhower et al, 2012) and MetaHIT (Qin et al, 2010) have generated maps of bacterial species abundances throughout the human body, reference genomes, and catalogs of more than 100 million microbial genes assembled from shotgun sequencing of in vivo communities.

A holistic understanding of the role of Earth's microbial community and its genome — its microbiome — in the biosphere and in human health is key to meeting many of the challenges that face humanity in the twenty - first century, from energy to infection to agriculture.