Sentences with phrase «microbicides in»
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Today, most microbicides in human studies or on the drawing board contain anti-HIV drugs that cripple a critical viral enzyme.
«This [set of studies] was the last hope for microbicides in many ways,» says Thomas Hope of Northwestern University's Feinberg School of Medicine in Chicago, Illinois.
Not exact matches
Researchers leading a large, ongoing study in women called VOICE that compares PrEP with pills to a vaginal microbicide plan to revaluate the ethics of continuing to use a placebo control group given the new evidence of oral Truvada's powerful impact.
As reported online this week in Science and in a presentation at the 18th International AIDS Conference in Vienna, of the 444 women who received a placebo gel, 60 became infected with HIV versus 38 infections in the 445 women who received the microbicide.
The largest study ever conducted of a microbicide designed to prevent HIV infection has resulted in yet another case of high hopes being dashed about a promising product.
That $ 90 million study, financed by the U.S. National Institutes of Health (NIH), startled many in the field who, based on other failures of nonspecific microbicides, had predicted the product would do nothing.
But the most promising candidates — compounds called vaginal microbicides that thwart the virus at the site of infection — have failed repeatedly in clinical trials.
When the gel comes in contact with semen, the change in pH causes it to reliquefy and release an HIV - killing microbicide.
«I don't think anyone suspected that the tenofovir gel would not work,» says immunologist John Moore, who works on microbicides at Weill Cornell Medical College in New York City.
After the microbicide showed promise in test - tube experiments, Haase's team moved on to rhesus macaques.
The researchers decided to test a microbicide that contains glycerol monolaurate (GML), a fatty acid that has proven safe in many products: It's used as a fiber finish in tampons and also as an emulsifier in many foods and cosmetics.
In addition to the expanded use of ARVs in new modalities such as pre-exposure prophylaxis and microbicides [1], this includes commensal microbicides [2], gene therapies [3], [4] and vaccines [5], [6], [7In addition to the expanded use of ARVs in new modalities such as pre-exposure prophylaxis and microbicides [1], this includes commensal microbicides [2], gene therapies [3], [4] and vaccines [5], [6], [7in new modalities such as pre-exposure prophylaxis and microbicides [1], this includes commensal microbicides [2], gene therapies [3], [4] and vaccines [5], [6], [7].
Janssen GPH will also prioritise work with the International Partnership for Microbicides developing the investigational drug dapivirine for use as a monthly vaginal microbicidal ring designed to prevent sexual transmission of HIV and continue its pact with Drugs for Neglected Diseases initiative for the preclinical research of a reformulated form of flubendazole for lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness), Janssen GPH is also developing a new, chewable formulation of Vermox (mebendazole) that will facilitate treatment of intestinal worms in younger children.
His contributions to microbicides for HIV prevention spans two decades and culminated in the CAPRISA 004 tenofovir gel trial which provided proof - of - concept that antiretroviral drugs can prevent sexually transmitted HIV infection and herpes simplex virus type 2 in women.
The ongoing Cape Town congress is itself a sign of change, aimed at bringing together researchers pursuing their different aims in vaccines, pre-exposure prophylaxis, and microbicides along with community members, policymakers, and advocates.
Pilar received her PhD in 2017 at the Complutense University of Madrid, where she studied immune cell dysfunction and hyperactivation in HIV / HCV coinfected patients, as well as the in vitro and in vivo activity of nanoparticles against HIV - 1 and HSV - 2 infections to prevent their transmission in humans as a topical microbicide.
Dr. Zeda Rosenberg, who leads the International Partnership for Microbicides, argued in Bangkok that a microbicide to protect women from HIV could be available within five years.
Community members and leading and upcoming Ugandan scientists engaged in dialogue on issues surrounding HIV vaccines, microbicides and pre-exposure prophylaxis (PrEP).
We tried to address some of these issues while working on an RNAi - based microbicide to prevent sexual transmission of viral infection (and ultimately HIV) in mice.
Results from an initial study combining a microbicide candidate and experimental vaccine are promising enough to at least keep Imperial College virologist Robin Shattock coming back for more in pursuing what could be a novel move in preventing HIV infection.
The Resource Tracking for HIV Prevention R&D Working Group (RTWG), led by AVAC, in partnership with the International AIDS Vaccine Initiative and UNAIDS tracks trends in R&D investments and expenditures for biomedical HIV prevention options, including AIDS vaccines, microbicides, multipurpose prevention technologies, pre-exposure prophylaxis (PrEP), treatment as prevention, medical male circumcision, female condoms, HSV - 2 vaccines, HIV cure and therapeutic vaccines.