Astonishingly, when germ - free mice are colonized with the gut
microbiota from genetically obese mice (ob / ob), the otherwise lean mice dramatically increase body weight.
In a later step of this study,
microbiota from obese mice fed with a western diet were transferred to the microbiota - free mice.
What's more, transferring
the microbiota from one inbred mouse strain with distinct behavior into another inbred (germ - free) strain is sufficient to transfer the host strain's behavior to the recipient7.
The idea was to first analyze the genomic DNA of
microbiota from children's stools for elements of microbiota flora and compare the treatment group to the control group both before and after KD while observing potential recoveries.
Panel (a) shows the PCoA of coprolites and the fecal
microbiota from extant indigenous cultures plotting PC1 vs. PC2.
«What this might suggest is that transfer of some of the «good»
microbiota from wild - type mice to replace the «bad»
microbiota from mice lacking AIM2 offers increased protection against colorectal cancer,» Man said.
Evaluation of milk sample fractions for characterization of milk
microbiota from healthy and clinical mastitis cows — Svetlana Ferreira Lima — PLOSone
Comparison of Oropharyngeal
Microbiota from Children with Asthma and Cystic Fibrosis.
For a control group comparison, the researchers also engrafted
microbiota from regular C57BL / 6 mice into a separate group of pregnant, germ - free mice.
Correlation between the Morisita - Horn dissimilarity index of the salivary
microbiota from couple members and (A) self - reported kiss frequencies or (B) self - reported time after the latest kiss.
Changes in the intestinal
microbiota from adulthood through to old age.
This is a visualization of the process of transferring gut
microbiota from wild mice to laboratory mice.
The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting
microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.
Transplant of
microbiota from emulsifiers - treated mice to germ - free mice was sufficient to transfer some parameters of low - grade inflammation and metabolic syndrome, indicating a central role for the microbiota in mediating the adverse effect of emulsifiers.
To define a relationship between gut bacteria and the efficacy of ACT, the researchers transplanted fecal
microbiota from Jackson mice to Harlan mice.
After seeding each reactor with a previously studied microbiome, and opening the setup to the acid whey and its own rich assortment of bacteria (such as common gut
microbiota from the Lactobacillus family), caproic acid, caprylic acid, and other minor products could be continually extracted over a period of several months.
When the team transferred
microbiota from a mouse with such dysfunctional ILC3s into a completely germ - free mouse, the recipient animal was highly susceptible to infections when later exposed to harmful bacteria.
Germ - free mice that received
microbiota from animals with functional ILC3s could fight off the bacteria.
The goal of the study was to explore whether fecal
microbiota from human IBS patients with diarrhea has the ability to influence gut and brain function in recipient mice.
Using fecal transplants, researchers transferred
microbiota from IBS patients with or without anxiety into germ - free mice.
In addition, cohousing coprophagic mice harboring transplanted
microbiota from discordant pairs provides an opportunity to determine which bacterial taxa invade the gut communities of cage mates, how invasion correlates with host phenotypes, and how invasion and microbial niche are affected by human diets.
We transplanted fecal
microbiota from adult female twin pairs discordant for obesity into germ - free mice fed low - fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet.
Separate groups of germfree mice were colonized with uncultured fecal
microbiota from each member of four twin pairs discordant for obesity or with culture collections from an obese (Ob) or lean (Ln) co-twin.
Moeller is beginning to assemble a snapshot of the microbes in the guts of our ancient ape ancestor — in essence, a paleo gut that fit our paleo diet — and hopes to go even further back in time if, as seems likely, all mammals have evolved their unique
microbiota from a common ancestral population in the distant past.
Ridaura et al. (1241214; see the Perspective by Walker and Parkhill) obtained uncultured fecal
microbiota from twin pairs discordant for body mass and transplanted them into adult germ - free mice.
«If we could assess a patient's
microbiota from a stool sample — especially if they are getting antibiotics — we could look at what bacteria are missing,» says Schubert, now a postdoctoral researcher in the Schloss laboratory.
The scientists transferred gut
microbiota from old and young conventional mice to young germ - free mice, and analysed immune responses in their spleen, lymph nodes and tissues in the small intestine.
«So far, it has not been sufficiently tested whether and how successful fecal transplantation is for the permanent settlement of
microbiota from a healthy donor to a patient,» said Alexander Loy of the Department of Microbiology and Ecosystem Research, University of Vienna.
Not exact matches
The PDF, Microbes Make the Cheese, A Report
from the American Academy for Microbiology explains: Cheese is created by orderly successions of microbial communities that produce compounds responsible for cheese flavor... Each piece of cheese contains as many as 10,000,000,000 or 10 billion microbes... The added starter cultures dominate the cheese
microbiota, establishing conditions that select for the next microorganisms that will be capable of thriving in the changing cheese matrix.
Prior update Nov 19, 2016 added Sonnenburg links (elimination of
microbiota - accessible carbohydrates (MACs)
from the diet results in thinner mucus, increased proximity of microbes to the epithelium, and heightened expression of inflammatory markers.)
«After birth the gut mucosa is challenged by a myriad of antigens,
from viruses to commensal
microbiota and dietary antigens.
Our objective was to evaluate the relative associations of delivery and feeding modes with the composition of the intestinal
microbiota at approximately 6 weeks of age in 102 infants
from a US pregnancy cohort study.
After transferring fecal matter
from one group of rodents to another, they observed similar changes in the gut
microbiota, acetate levels, and insulin.
Prof. Severine Vermeire (KU Leuven / UZ Leuven): «In the future, gut bacteria may be used to help identify PSC patients with a more or less aggressive disease, or patients that may benefit
from microbiota - based therapies, such as fecal
microbiota transplantation or targeted pre - and probiotics.»
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data
from dogs to study the impact of diet on gut
microbiota in humans, and humans could be a good model to study the nutrition of dogs.
In the first study, scientists transplanted fecal material
from exercised and sedentary mice into the colons of sedentary germ - free mice, which had been raised in a sterile facility and had no
microbiota of their own.
The studies were designed to isolate exercise - induced changes
from other factors — such as diet or antibiotic use — that might alter the intestinal
microbiota.
Exposure to lead during early development can alter the the gut
microbiota, increasing the chances for obesity in adulthood, researchers
from the University of Michigan School of Public Health have found.
The new study explains how this
microbiota might delay the onset of cancer, and suggests that probiotic supplements could help keep cancer
from forming.
Moreover, obese - phenotype mice were invaded by members of the Bacteroidales
from the lean mice, but, happily, the lean animals resisted invasion by the obese
microbiota.
Research
from McMaster University has found that bacteria in the gut impacts both intestinal and behavioural symptoms in patients suffering
from irritable bowel syndrome (IBS), a finding which could lead to new
microbiota - directed treatments.
Interestingly, the authors noted that since the study showed that
microbiota in the gut can influence the brain, it «adds to evidence suggesting that the intestinal
microbiota may play some role in the spectrum of brain disorders ranging
from mood or anxiety to other problems that may include autism, Parkinson's disease and multiple sclerosis.»
Disruptions in the
microbiota composition, and subsequently the metabolites derived
from the
microbiota, are increasingly correlated not only to GI diseases such as inflammatory bowel disease (IBD) and colitis, but also to insulin resistance and Type 2 diabetes.
Researchers
from Inserm, Paris Descartes University and the CNRS (French National Centre for Scientific Research), through collaboration with teams
from China and Sweden, have recently shown how
microbiota protects against the development of type 1 diabetes.
«The results help to support the assumption that the gut
microbiota is not — as previously thought — stable
from the moment a child is a year old.
«Up until now, it was impossible to study the impact of probiotics on gut
microbiota at a bacterial species level;
from now on we will have a much more detailed view of the dynamics of this ecosystem» says Dusko Ehrlich.
Particularly the
microbiota of the children who had received macrolide antibiotics, such as azithromycin or clarithromycin, within the past two years differed
from normal.
Reducing TNF levels rescues
microbiota changes and protects old mice
from intestinal permeability.
The investigators found that despite their diet, these giant pandas, together with nine captive and seven wild individuals investigated previously, showed extremely low gut
microbiota diversity and an overall structure that diverged
from non-panda plant - eaters but was similar to carnivorous and omnivorous bears.
«The results
from the study can be used to support initiatives that can be used to help children develop a type of gut
microbiota, which is beneficial for the immune system and for the digestive system.