In my previous article, I described how each of us possesses a gut
microbiota with a unique population of microbes and that our uniqueness may influence the efficacy of the probiotic supplements that we use.
The candida diet works by «starving» the excess candida and taking away their primary food sources (namely sugars), while simultaneously rebuilding your gut
microbiota with nourishing, probiotic and prebiotic - rich foods.
Since a change in composition of gut microbiota is also suggested to be the underlying factor for the development of obesity, it is obvious to link gut
microbiota with the pathogenesis of diabetes.
Their procedure involved infecting mice without
microbiota with either microbiota of obese or lean mice.
Gastrointestinal ailments are frequently associated with anxiety and imbalanced mood, and many researchers theorize that affected persons could alleviate symptoms simply by balancing the gut
microbiota with more beneficial bacteria.
A new study recently measured the gut microbiota in 728 female twins with varying degrees of frailty and discovered that people with a high Frailty Index (a measurement of frailty) possess gut
microbiota with significantly lower diversity than those with low Frailty Index scores.
An improved understanding of the association of the NP
microbiota with LRTI may lead to the development of new tools for diagnosis or risk prediction.
The direct and indirect association of cervical
microbiota with the risk of cervical intraepithelial neoplasia — Chaoting Zhang — Cancer Medicine
«There is considerable evidence that dietary prebiotics modulate the gastrointestinal
microbiota with therapeutic applications to conditions, including irritable bowel syndrome, inflammatory bowel disease, obesity and bone health,» according to the researchers.
Numerous recent studies linked gut
microbiota with various diseases such as obesity or diabetes.
Not exact matches
In the most recent of these reports (in the latest issue of Science), Dr. Jennifer Wargo, a surgeon and research scientist at M.D. Anderson, along
with several dozen colleagues at other institutions, reveal that the composition of a patient's gut
microbiota can significantly influence whether he or she responds to an immune checkpoint inhibitor — the type of cancer immunotherapy that releases the emergency brakes in the car analogy above.
How do the microbes within cheese interact
with the natural
microbiota of the human gut and can cheese be used to assist in maintaining a healthy gut
microbiota?
Using a «gnotobiotic mouse model» — where mice were «colonized
with a synthetic human gut
microbiota composed of fully sequenced commensal bacteria» — Desai et al reported on the effects of different diets
with different fibre content.
A recent research study conducted by the Sahlgrenska Academy at University of Gothenburg in Gothenburg, Sweden, in collaboration
with DuPont Nutrition & Health (DuPont), yielded breakthrough results demonstrating that probiotic intervention can alter and modify intestinal
microbiota in patients
with colon cancer.
Genetic testing to identify nutritional needs and digital models for analysing food interactions
with gut
microbiota.
Another way I say «thanks for teaching me about gut
microbiota and extra virgin olive oil» is
with food.
Our objective was to evaluate the relative associations of delivery and feeding modes
with the composition of the intestinal
microbiota at approximately 6 weeks of age in 102 infants from a US pregnancy cohort study.
61 The distinction between exclusive breastfeeding and partial breastfeeding in the analyses of the association between breastfeeding and the risk for childhood leukemia is essential given that the addition of infant formula, together
with breast milk or instead of it, changes the infant's gut
microbiota, affecting the immunology of the infant.62, 63 Thus, misclassification might weaken the association between breastfeeding and lower risk for childhood leukemia.
A previous study highlighted infant nutrition as a major contributor to the early
microbiota composition and function,
with cessation of breastfeeding contributing the most fundamental shift in the composition of bacteria.8 A longitudinal study
with more participants would allow us to determine the temporal dynamics of the effects of feeding practices and changes therein, as well as the persistence of the effects of both feeding and delivery mode later in infancy.
With the gut
microbiota now being linked to so many different health conditions, there is a growing interest in microbial therapies that look to alter the balance of microbes to improve health.
In collaboration
with Synchrotron Oxford, the University of East Anglia and the University of California, the researchers, using a commonly - found member of human gut
microbiota called Ruminococcus gnavus as a model organism identified carbohydrate binding modules
with the ability to bind to mucus.
Over 100 different oligosaccharides have been identified in the human colon, and recent research has shown that variations in the oligosaccharides within the mucus are associated
with variations in the composition of the gut
microbiota.
«Alterations in the gut
microbiota are associated
with obesity and the metabolic syndrome in both humans and rodents,» Shulman noted.
The inflammation cluster research groups led by Saleh Ibrahim of the University of Lübeck, and John Baines of the MPI and CAU, correlated the genomic variations of hundreds of mice that partially develop skin inflammatory diseases
with skin
microbiota.
Prof. Severine Vermeire (KU Leuven / UZ Leuven): «In the future, gut bacteria may be used to help identify PSC patients
with a more or less aggressive disease, or patients that may benefit from
microbiota - based therapies, such as fecal
microbiota transplantation or targeted pre - and probiotics.»
The Wyss team believes the ability of the human gut - on - a-chip to culture the microbiome
with human gut cells also holds promise for the field of precision medicine, where a patient's own cells and gut
microbiota could one day be cultured inside a gut - on - a-chip for testing different therapies and identifying an individualized treatment strategy.
A team led by gastroenterologists Sieglinde Angelberger and Walter Reinisch (Medical University Vienna) and microbiologists David Berry and Alexander Loy (University of Vienna) explored how a treatment called «fecal
microbiota transplantation» can be used to support microbial recolonization of the gut of patients
with chronic intestinal inflammation (ulcerative colitis).
Researchers working on the Ribeirão Preto campus of the University of São Paulo (USP) in Brazil have discovered that a bacterium found in the
microbiota associated
with leafcutter ant species Atta sexdens rubropilosa produces the so - called «trail pheromones,» i.e, the aromatic chemical compounds used by the ants to lay a trail to their nest.
They compared the abundance of
microbiota in rats given continuous access to either a healthy diet or junk food
with a group cycled between the two diets, healthy for four days and junk for three, over 16 weeks.
The review centers on a first of its kind study in which researchers characterized the gut bacterial
microbiota (bacteriome) and fungal community (mycobiome) in a number of families that had members
with CD and healthy relatives.
Kristen Earle, Gabriel Billings, KC Huang and Justin Sonnenburg, of Stanford University's School of Medicine, Department of Microbiology and Immunology, took second place
with this photo of a mouse colon colonized
with human
microbiota, seen at 63x.
Along
with a postdoc in Kaplan's lab, Alice Liou, they decided to test whether the surgery itself caused the changes in the population of gut microbes — known as the
microbiota.
«Since inflammaging is thought to contribute to many diseases associated
with ageing, and we now find that the gut
microbiota plays a role in this process, strategies that alter the gut
microbiota composition in the elderly could reduce inflammaging and promote healthy ageing,» explains Dr Floris Fransen, who performed the research at the University Medical Center Groningen, The Netherlands.
«We also found differences in the gut
microbiota composition between those children taking a disease - modifying drug for their disease compared
with those who were not.
«Fecal
microbiota transplantation has been very successful for many patients
with C. difficile infections, but we've never known why.
«These findings suggest that bi-directional communication is occurring,
with stress impacting the
microbiota, and on the other hand,
with some specific bacteria in turn impacting the response to stress,» said Dr. Benoit Chassaing, assistant professor in the Neuroscience Institute at Georgia State.
People
with primary depression, for example, show alterations in the
microbiota.
«You could perhaps give patients a probiotic supplement
with the goal of restoring their
microbiota community structure to a healthy state.»
The article focuses mainly on patients
with cancer, who often undergo treatments that can cause profound alterations in the gut
microbiota and potentially contribute to the development of complications.
Development of a healthy gut
microbiota can have a lifelong effect on health, and early intervention in the establishment of that
microbiota could have lifelong positive effects: The early establishment of bifidobacteria has been shown to be associated
with improved immune response to vaccines, development of the infants» immature immune system, and protection against pathogens.
Kilner adds that there are potential parallels
with the way the human immune system interacts
with the gut
microbiota: «The language in this field is now more about management than warfare.»
Separate groups of germfree mice were colonized
with uncultured fecal
microbiota from each member of four twin pairs discordant for obesity or
with culture collections from an obese (Ob) or lean (Ln) co-twin.
In addition, cohousing coprophagic mice harboring transplanted
microbiota from discordant pairs provides an opportunity to determine which bacterial taxa invade the gut communities of cage mates, how invasion correlates
with host phenotypes, and how invasion and microbial niche are affected by human diets.
Cohousing mice harboring an obese twin's
microbiota (Ob)
with mice containing the lean co-twin's
microbiota (Ln) prevented the development of increased body mass and obesity - associated metabolic phenotypes in Ob cage mates.
«Can chemicals produced by gut
microbiota affect children
with autism?.»
Using fecal transplants, researchers transferred
microbiota from IBS patients
with or without anxiety into germ - free mice.
The goal of the study was to explore whether fecal
microbiota from human IBS patients
with diarrhea has the ability to influence gut and brain function in recipient mice.
«This is a landmark study because it moves the field beyond a simple association, and towards evidence that changes in the
microbiota impact both intestinal and behavioral responses in IBS,» said Giada De Palma, the study's first author and research associate
with the Farncombe Family Digestive Health Research Institute.
«It's increasingly clear that our gut bacteria, or
microbiota, can communicate
with the human brain,» said Kathy Magnusson, a professor in the OSU College of Veterinary Medicine and principal investigator
with the Linus Pauling Institute.
In the study, the gut
microbiota of the animals that were fed a diet rich in sugar and fat have a diminished capacity to communicate
with host cells.