Although Brazil is the only country to report a spike in
microcephaly during the current outbreak, French Polynesia in 2014 saw a rise in this rare disorder concurrent with viral spread, Chan said.
The scientists rescued
the microcephaly during mouse embryonic development by removing a protein that caused the loss of stem cells.
Not exact matches
One of the reasons it's been so troubling is that it's a cause of a serious birth defect called
microcephaly, in which the head of babies whose mothers have been infected with Zika
during pregnancy are abnormally small.
«There is no evidence linking any vaccine to the increases in
microcephaly cases that were observed first in French Polynesia
during the 2013 - 2014 outbreak and more recently in northeastern Brazil,» the WHO said in a statement.
The agency said there have been recent variations in the number of cases reported in the region and, while the level of risk is unknown, Zika virus infection
during pregnancy causes severe birth defects, including
microcephaly and other severe brain abnormalities.
Earlier on Friday, U.S. health officials published a study estimating that as many as 270 babies in Puerto Rico may be born with the severe birth defect known as
microcephaly caused by Zika infections in their mothers
during pregnancy.
The finding strengthens the evidence that a mother's Zika infection
during pregnancy raises her baby's risk of
microcephaly and other brain malformations.
Scientists have linked infections
during pregnancy to stillbirths and birth defects such as
microcephaly, where a baby's head is abnormally small.
Neither set of pups developed
microcephaly, which Diamond says could be because the researchers infected the mothers so early
during pregnancy that not much brain development had yet occurred.
«The majority of cases of
microcephaly and other central nervous system defects are still undergoing investigation to determine whether they are linked to Zika virus infection
during pregnancy,» a CDC spokesperson told ScienceInsider.
For example, MCPH1 and ASPM cause
microcephaly when mutated, FOXP2 causes speech defects, and all three show signs of selection pressure
during human, but not chimp, evolution.
ZIKA BABIES Zika infection
during pregnancy substantially raises the risk that the baby will have certain birth defects, such as
microcephaly and other brain deformations.
An association between Zika infections
during pregnancy and the birth of babies with
microcephaly (a birth defect in which an infant's brain does not develop properly resulting in a smaller than normal head) was first suggested by Brazilian physicians in August 2015, and in November
microcephaly cases potentially associated with Zika started to be recorded; three months later WHO made its announcement.
Zika virus infection
during pregnancy has been linked to congenital brain abnormalities, including
microcephaly, and Zika virus is a trigger of Guillain - Barré syndrome.
Zika virus infection
during pregnancy can result in
microcephaly and other serious birth defects in the fetus, making the development of a safe and effective vaccine a global health priority.
If that happens
during the key phases of brain development in the first 3 to 4 months of pregnancy, the overall size of the brain would be dramatically reduced, leading to
microcephaly.
While the Zika virus typically causes a relatively mild illness, infection
during pregnancy can cause
microcephaly and other devastating congenital malformations.
In humans, Zika virus infection
during pregnancy has been linked to a suite of birth defects including a condition known as
microcephaly, which leaves babies with shrunken heads and brains (SN: 4/2/16, p. 26).
Data from the Brazilian metropolis have confirmed this suspicion and, together with other studies, enable the researchers to estimate the absolute risk of
microcephaly upon infection of the mother
during pregnancy: approximately one out of 100 mothers infected
during early pregnancy will bear a child with
microcephaly.
«The increased number of newborns with
microcephaly observed
during the Zika outbreak in Brazil is linked to Zika infection of the mother
during early pregnancy,» explains Drexler.
Since 2016 thousands of children across South America have been born with
microcephaly, which causes abnormally small heads, after their mothers became infected with the Zika virus
during pregnancy.
They represent the greatest health crisis because a Zika infection
during the first trimester confers the greatest risk of congenital
microcephaly.»
Petersen's remarks were among the strongest suggestions yet from a top CDC scientist that Zika infection
during pregnancy can — at least in some cases — cause
microcephaly, a condition in which infants are born with abnormally small heads and possibly brain damage.
The birth prevalence of neonatal
microcephaly and other central nervous system malformations greatly increased between 2015 and mid-2016 in Brazil.1 - 3 Several reports1,2,4 - 6 suggested an association between these findings and Zika virus (ZIKV) infection
during outbreaks in Brazil and French Polynesia.
Long before Zika virus made it a household word, the birth defect called
microcephaly puzzled scientists and doctors — even as it changed the lives of the babies born with it
during the pre-Zika era.
In their follow up modelling study they reported Zika virus infection
during the first trimester of pregnancy led to higher than expected rates of
microcephaly.
The FBDS phenotype has been reported in an infant with laboratory - confirmed ZIKV infection, 13 in a neuroimaging report documenting cranial bone collapse in infants born to mothers with suspected ZIKV infection
during pregnancy, 14 and a recent case series of infants with probable ZIKV - associated
microcephaly.38 In 3 of the largest case series reporting 35, 48, and 104 infants primarily with suspected congenital ZIKV infection, 33,37,38 approximately two - thirds of infants had severe
microcephaly.
Based on data from population - based birth defects surveillance programs for 2009 - 2013, the median prevalence of
microcephaly in the United States was approximately 7 per 10000 live births.29 There are no published estimates of the prevalence of the birth defects potentially related to Zika virus infection
during pregnancy combined.
The included birth defects were based primarily on case reports of outcomes occurring in association with Zika virus infection
during pregnancy; there is more evidence for some of these birth defects than for others, and a causal link has not been established for all.5,10,12,21 - 27 Because much of the focus to date has been on
microcephaly and brain abnormalities, data were summarized in 2 mutually exclusive categories: (1) brain abnormalities with or without
microcephaly regardless of the presence of additional birth defects and (2) neural tube defects and other early brain malformations, eye abnormalities, and other consequences of central nervous system dysfunction among those without evident brain abnormalities or
microcephaly.
«Among infants of mothers exposed to Zika virus
during pregnancy, the absence of
microcephaly at birth does not rule out congenital Zika virus infection or the presence of Zika - related brain abnormalities,» according to a news release from the U.S. Centers for Disease Control and Prevention.
Based on a newly published systematic review of current research, WHO has reaffirmed its position that Zika virus infection
during pregnancy is a cause of congenital brain abnormalities, including
microcephaly, and refined its position on the relationship between Zika virus infection and Guillain - Barré syndrome, stating that Zika virus infection is a trigger of Guillain - Barré syndrome.