Sentences with word «microenvironment»

Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.

On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.

An anticancer agent, pyrvinium pamoate inhibits the NADH - fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments.

For efficiently studying cell functions, it is essential to reconstruct cellular microenvironments by parallel manipulation of single cells.

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.

Marina Prewitz (Werner, LG)-- «Decellularised extracellular matrices as instructive microenvironments for bone marrow derived stem cells» (2011)

The cell microenvironment contains chemical and physical cues that arise from a complex, albeit defined, architecture of extracellular matrix networks.

Other critical factors to consider include the mucosal immune system and the potential impact of a tolerogenic microenvironment on the development and progression of disease.

The researchers analyzed the samples using immunohistochemistry and RNA sequencing to study the changes in the tumor immune microenvironment of patients who received and did not receive chemotherapy, and changes before and after chemotherapy.

For example, both adult males and females exposed to lead during early development had fewer aerobes and significantly more anaerobes, suggesting a changing microenvironment of the gut.

We evaluated the rainbow PNBs for the selective ablation of cancer cells surrounded by non-cancer stromal cells (a typical cancer microenvironment described above for the diagnostic stage).

The Nefedova laboratory focuses on understanding the role of bone marrow microenvironment in regulation of tumor progression and therapy resistance.

Kehr, J. Monitoring chemistry of brain microenvironment: biosensors, microdialysis and related techniques.

Nefedova studies molecular mechanisms by which bone marrow microenvironment promotes tumor survival and progression.

In her project, Sipkins will investigate molecular characteristics of tissue microenvironments, or «niches,» within the bone marrow and how normal, healthy hematopoietic stem cells, which give rise to the many kinds of blood cells, compete with malignant cells to occupy these coveted niches.

«While genetic mutations are at the root of cancer, a number of studies over the last 10 to 20 years have implicated the cellular microenvironment as playing a key role in promoting or suppressing tumor progression,» says lead author Ovijit Chaudhuri, a former postdoctoral fellow in the Mooney Lab at Harvard who recently joined the mechanical engineering faculty at Stanford University.

Next, Mao and colleagues developed a way to study how genes and the tumor microenvironment influence cancer development.

Furthermore, the role the host microenvironment plays in tumor biology provides an exceptional opportunity for novel therapeutic strategies.

Seaweeds create a chemical microenvironment at their surface, providing refuge for calcifying organisms that are at risk from decreasing oceanic pH.

In light of these realizations, the long - term scientific goal of the program is to develop a detailed and mechanistic understanding of not just the tumor cell and tumor mutations, but also all the components of the host microenvironment that influence cancer and the response to cancer therapy.

Yet in a study led by Aimy Sebastian, a graduate student in the School of Natural Sciences at UC Merced who is conducting her Ph.D thesis work under Loots, identified the secreted bone protein Sclerostin (SOST), as a key molecule dysregulated as a result of prostate cancer - bone microenvironment interactions.

But T cells typically can not attack tumors because the immunosuppressive microenvironment of tumors keeps APCs from turning these signals on.

Development and validation of a modular 3D microenvironment platform technology for studying prostate cancer - induced bone metastasis.

Chronic Bile Duct Injury Associated with Fibrotic Matrix Microenvironment Provokes Cholangiocarcinoma in p53 - Deficient Mice

The idea is to introduce a biodegradable scaffold under the skin that temporarily creates an «infection - mimicking microenvironment,» capable of attracting, housing, and reprogramming millions of dendritic cells over a period of several weeks.

«Hypoxia can occur for many reasons, but in early FOP flare - ups, we speculated that hypoxia might result from the inflammatory microenvironment in lesions,» Kaplan said.

SynNotch T cells can thus be used as a general platform to recognize and remodel local microenvironments associated with diverse diseases.

She will determine which cells harbor the most latent and productive HIV and examine the cells» total gene expression to determine how the gut microenvironment contributes to their long - term survival.

University of Illinois researchers have developed a new technique to create a cell habitat of squishy fluids, called hydrogels, which can realistically and quickly recreate microenvironments found across biology.

By studying ovarian stem cells, they are learning how cells maintain an undifferentiated state and how cell production is regulated by microenvironments known as niches.

It is believed that chronic wounds get stuck in an inflammatory phase, with a low - oxygen microenvironment and the persistent presence of enzymes that break down tissue proteins.

Phenotypic Characterization of Prostate Cancer LNCaP Cells Cultured within a Bioengineered Microenvironment.

These studies reveal a crosstalk between the two conserved developmental pathways in human skin, and highlight the role of the skin microenvironment in driving the generation of stem cells, and possibly tumor - initiating cells.

The tumour microenvironment contains rapidly dividing rogue cells that compete for limited resources.

Furthermore, it is becoming clear that CSCs require niche for their growth and they need to either adapt themselves to the existing niche or to generate their own niche in the distant organs that have totally different microenvironment from the primary tumor (38).

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

The fact that FOX01 behaves in this unexpected way could have to do with the specialized microenvironment of a cell in a wound, Graves noted.

«Altered microenvironment promotes progression of pre-invasive breast cancer: myoepithelial expression of integrin DCIS identifies high - risk patients and predicts recurrence» by Michael D Allen et al. published in Clinical Cancer Research on Tuesday 3 December.

Wherever they gather, mitochondria change the local chemical microenvironment: They cause a lower pH, and that small change, Van Blerkom believes, can affect the local activity of certain enzymes.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

The starter culture changes the cheese microenvironment, affecting a variety of factors, including pH, redox potential, levels of organic acids such as lactate and acetate, and other nutrients.

«We need to better understand the complex sleep microenvironment to improve it and reduce the harmful effects of related pollutants on infants,» Corsi said.

By mimicking normal blood flow, the mechanical microenvironment, and how different tissues physically interface with one another in living organs, they offer a more systematic approach to testing drugs than other in vitro methods that ultimately could help to replace animal testing.

This tumor - protecting microenvironment includes inflammatory white blood cells called monocytes and macrophages.

The scenario was ideal for targeting plaque, which can produce an acidic microenvironment when exposed to sugars.

«I think that we've produced a 3 - D microenvironment which is much more like that found in vivo for growing embryoid body, which explains the higher levels of cell proliferation.»

The findings support the hypothesis that FOP lesions thrive in a hypoxic microenvironment, not simply due to oxygen deprivation, but also because of a maladaptive response to hypoxia by the HIF - 1α molecular alarm, similar to that seen in cancer.