Sentences with phrase «microenvironment at»
Seaweeds create a chemical microenvironment at their surface, providing refuge for calcifying organisms that are at risk from decreasing oceanic pH.
https://www.britishecologicalsociety.org/ Not exact matches
«We're interrogating the tumor microenvironment,» she says, «by looking at suppressive cues as well as cells and secreted proteins that protect tumors from the immune response.»
But following the removal of the primary tumor, micrometastatic cells learn to communicate with cells in their new microenvironment in the brain — cells which are, at first, hostile to them.
Yet in a study led by Aimy Sebastian, a graduate student in the School of Natural Sciences at UC Merced who is conducting her Ph.D thesis work under Loots, identified the secreted bone protein Sclerostin (SOST), as a key molecule dysregulated as a result of prostate cancer - bone microenvironment interactions.
The cell influences its microenvironment and, at the same time, the microenvironment influences cellular behavior — I am exploring this interrelationship.
«Dendritic cells are essential for prompting the immune response against malignant cells and for driving the clinical success of cancer immunotherapy, but their function is often defective in cancer patients,» said Dmitry I. Gabrilovich, M.D., Ph.D., Christopher M. Davis Professor and program leader of the Immunology, Microenvironment & Metastasis Program at Wistar.
«It shows that the egg is playing an active role in creating the microenvironment that it needs to continue its development,» says Dr. Clarke, lead study author, who is also a senior scientist from the Child Health and Human Development Program at the RI - MUHC and a professor and research director of the Department of Obstetrics and Gynecology at McGill University.
«These findings suggest that BLBC cells have an innate ability to establish a local microenvironment that is supportive of cancer stem cells,» explained Thiagalingam, associate professor in Genetics & Genomics, Medicine, and Pathology & Laboratory Medicine, at BUSM.
But a closer look at the microenvironment surrounding tumors found the unexpected.
The research team of Dr Bassam Janji in the Laboratory of Experimental Cancer Research at LIH's Department of Oncology is specialized in the study of the tumor microenvironment in different types of solid tumors, including skin cancer.
«If we want to understand the role of estrogen, we now have to look at how the tumor and the microenvironment communicate with one another,» den Boon says.
«SynNotch receptors essentially allow us to confine the T cell response at the site of disease with the goal of enhancing the ability of the T cell to, for example, overcome the inhospitable microenvironment of a solid tumor.
«With Teresa Woodruff's research using Draper's human organ system platform, we have a compelling demonstration of the importance of a microenvironment that permits cells to function in vitro as they would in vivo, and the power of being able to interconnect organ models on a platform and operate them in a stable and precise manner for weeks to months,» said Jeffrey T. Borenstein, a biomedical engineer at Draper.
Timothy Wang at Columbia recently published work in Cancer Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel therapy.
«Because the primary Small Intestine Chip recapitulates the physical microenvironment that cells experience inside the human body, such as fluid flow and cyclic peristalsis - like stretching motions, it exhibits a genome - wide gene expression profile that comes closer to its in vivo counterpart than that of the same intestinal cells grown as 3D organoids,» said first - author Magdalena Kasendra, Ph.D., a former Postdoctoral Fellow on Ingber's team and now Principal Scientist at Emulate, Inc. in Boston.
«Our research has identified the right soil for seeds to flourish by looking at the microenvironment in the breast and examining the mechanisms at play.
«Our research shows that the protein GSK3 plays a crucial role in helping B cells meet the energy needs of their distinct states,» says Robert Rickert, Ph.D., director of the Tumor Microenvironment and Cancer Immunology Program at Sanford Burnham Prebys Medical Discovery Institute (SBP).
When they put stem cells into this viscoelastic microenvironment and tuned the rate at which the gel relaxed, they observed dramatic changes in the behavior and differentiation of the cells.
We decided to look at the exosomes of stromal cells, a type of cell that is commonly found in the tumor microenvironment, and see if stromal exosomes were influencing the energy consumption of cancer cells.»
«Our original hypothesis was that cancer cells were modifying their metabolism based on communications they were receiving from cells in the microenvironment near the tumor,» said Nagrath, assistant professor of chemical and biomolecular engineering at Rice and co-author of a new study describing the research in the open - access journal eLife.
This discovery by Siyuan Zhang at the University of Notre Dame and a team at the University of Texas MD Anderson Cancer Center has focused attention on fighting cancer in the tumor cell's microenvironment.
The method was effective at making the tumour microenvironments susceptible to treatment.
We expect that the CRI iAtlas will help to accelerate discovery and improve patient outcomes by providing researchers greater access to genomics data to better understand the immunological characteristics of the tumor microenvironment and its potential impact on patient responses to immunotherapy,» said Jill O'Donnell - Tormey, Ph.D., CEO and director of scientific affairs at CRI.
Before he joined Moderna in 2013, Dr. Frederick was a Translational Research group leader at Aveo Oncology, focused on the generation of biomarkers for therapeutic response prediction, as well as avenues to modulate the tumor microenvironment for therapeutic benefit.
This advance will allow biomedical scientists to study the functioning of an individual's intestinal lining in a controlled microenvironment, where the lining can interact with immune cells, blood cells and drugs, said Robert Barrett, PhD, assistant professor of Medicine and research scientist at the Cedars - Sinai Board of Governors Regenerative Medicine Institute.
October 28, 2009 Dr. Charis Eng delivers Keynote Address at the University of Alabama, Birmingham Comprehensive Cancer Center Research Retreat Charis Eng, MD, PhD, FACP, Sondra J. and Stephen R. Hardis Chair of Cancer Genomic Medicine, and Founding Chair and Director of the Genomic Medicine Institute delivered the Keynote Address entitled, «Germline homozygosity, cancer predisposition and tumor microenvironment.»
Research in the Immunology, Microenvironment and Metastasis program is aimed at 1) merging basic mechanistic understanding of multidisciplinary pathways of host - tumor interactions and metastatic dissemination with novel translational opportunities for diseases diagnosis and immunotherapy, as well as 2) investigating mechanisms regulating immune responses in cancer and their potential therapeutic manipulation.
«This comes at a time when unprecedented development of novel immune agents is intersecting with our deeper understanding of colorectal molecular subtypes and of the complexities of the tumor microenvironment.»
Scientists at The Wistar Institute Melanoma Research Center have made huge strides in understanding the biology that underlies this disease, from basic genetics to the study of melanoma cell interaction with the microenvironment and new concepts that describe the stem cell - like abilities of melanoma to evade treatment.
Our research aims at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering disease - relevant targets that can be harnessed to drive drug discovery efforts in neurological and age - related neurodegenerative diseases.
«Visualizing how cancer cells interact with a tumor microenvironment that accurately reflects the complex biology of ovarian cancer should help us understand the mechanisms underlying metastatic progression as well as identify new therapeutics that can inhibit this process,» said clinical gynecologic oncologist Ernst Lengyel, MD, PhD, senior author of the study and a professor of obstetrics and gynecology at the University of Chicago.
This multi-stage process requires tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it involves contributions from both the tumour cell and tumour microenvironment («host», which includes stromal cells and the immune system).
«Our results point to a new and more personalized strategy to modulate the tumor microenvironment,» said study director Yang - Xin Fu, MD, PhD, professor of pathology at the University of Chicago.
Dr. Odunsi will also be the featured presenter at an April 18 Meet the Experts session, «Reprogramming the Tumor Microenvironment to Enhance «Next - Generation» Adoptive Cellular Therapy.»
According to new research by Thomas Weber, an assistant professor of Earth and environmental sciences at the University of Rochester, small microenvironments in the deep ocean may hold key clues to the global cycling of nitrogen in seawater.
His dome series such as Cultivation of Nature & People Who Are Looking At It (1970 - 1971) and Portrait Ionesco (1971) appear like microenvironments undergoing experimentation in a scientific laboratory.
And thus it would have meant the end of human civilization and essentially all modern mammalian — including human — life on essentially almost all the planet, since modern mammals can not survive with typical summertime afternoon heat indexes around 200 degrees F or have viable populations at even just 150 degrees F without suitable microenvironments to retreat into.)