Sentences with phrase «microenvironment in»

It helps to create a microenvironment in the gut, which helps in the absorption of minerals by the body and improves overall digestive health.

Title: The immune microenvironment in hormone receptor - positive breast cancer and treatment outcome following preoperative chemotherapy plus bevacizumab Date / Time: Tuesday, April 17 2018, 1:00 pm - 5:00 pm CT Author: A. Waks et al, Dana Farber Cancer Institute Poster # / Location: 4565 / Section 26, Board 1 Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7859 HR + / HER2 - breast tumors with higher levels of tumor immune activity have a more favorable response to chemo plus bevacizumab.

These studies reveal a crosstalk between the two conserved developmental pathways in human skin, and highlight the role of the skin microenvironment in driving the generation of stem cells, and possibly tumor - initiating cells.

The critical roles of tumor - initiating cells and the lymph node stromal microenvironment in human colorectal cancer extranodal metastasis using a unique humanized orthotopic mouse model.

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

Nevertheless a role for these cells can not be excluded, it is possible that an incomplete replication of the suppressive microenvironment in vitro or indeed the diversity of Treg populations mean that these studies do not fully explore the potential role of suppressive or regulatory T cells in promoting MSC tolerance.

The Nefedova laboratory focuses on understanding the role of bone marrow microenvironment in regulation of tumor progression and therapy resistance.

On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.

Michael Gershon, MD, Pathology & Cell Biology, will receive $ 2,193,710 over five years from the National Institute of Neurological Disorders and Stroke for «Microenvironment in Enteric Neuron Development» in a competitive renewal.

«Our research has identified the right soil for seeds to flourish by looking at the microenvironment in the breast and examining the mechanisms at play.

In cancer, the protein helps malignant tumors evade the immune system as they metastasize and alter their microenvironment in a stealth type of expansion.

«Hypoxia can occur for many reasons, but in early FOP flare - ups, we speculated that hypoxia might result from the inflammatory microenvironment in lesions,» Kaplan said.

The research team of Dr Bassam Janji in the Laboratory of Experimental Cancer Research at LIH's Department of Oncology is specialized in the study of the tumor microenvironment in different types of solid tumors, including skin cancer.

But following the removal of the primary tumor, micrometastatic cells learn to communicate with cells in their new microenvironment in the brain — cells which are, at first, hostile to them.

But until now, scientists have been hard - pressed to develop new therapies for treating IBDs due to their inability to replicate the human gut microenvironment in the laboratory.

The acceleration of the healing process occurs due to changes in the microenvironment in the wound, which change the behaviour of specific immune cells.

In both cases, paclitaxel changed the tumor microenvironments in three ways, all more conducive to metastasis: The microenvironment had more of the immune cells that carry cancer cells into blood vessels, it developed blood vessels that were more permeable to cancer cells, and the tumor cells became more mobile, practically bounding into those molecular Lyfts.

Altered stromal microenvironments in non-lymphoid organs may also impact immune function.

Dr. Matsuzaki has accumulated extensive expertise in T - cell biology and mechanisms of immune suppression in periphery and tumor microenvironments in patients with ovarian cancer.

According to new research by Thomas Weber, an assistant professor of Earth and environmental sciences at the University of Rochester, small microenvironments in the deep ocean may hold key clues to the global cycling of nitrogen in seawater.

Not exact matches

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

In a sense proximity to parents during the night acts as a buffer between the immature infant and the microenvironment within which it lives.

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

Changing the concentration of the enzyme's substrate molecule in the model produced an outcome that described how ATP synthase interacts with its microenvironment.

It's this «immunosuppressive» microenvironment that gives the remaining tumor cells license to metastasize and flourish in other parts of the body.

«However, many patients do not respond because myeloid derived suppressor cells (MDSCs), a type of inhibitory cell, are present in the tumour microenvironment.»

Changes in the ovarian microenvironment, such as reduced oxygen supply to the growing follicles are likely causes of ovarian aging, according to Patrizio.

«This technique creates a steady, sustained release of antibodies directly into the tumor site; it is an efficient approach with enhanced retention of anti-PD-1 antibodies in the tumor microenvironment,» says Zhen Gu, an assistant professor in the biomedical engineering program and senior author of the paper.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

Yet in a study led by Aimy Sebastian, a graduate student in the School of Natural Sciences at UC Merced who is conducting her Ph.D thesis work under Loots, identified the secreted bone protein Sclerostin (SOST), as a key molecule dysregulated as a result of prostate cancer - bone microenvironment interactions.

Kilian said his team's synthetic microenvironment lies somewhere in the middle of two extremes in the field of modeling biology: the hard plastic plate, and expensive mouse avatars that are created by injecting human tumor cells into mice.

«Taken together, these results support the hypothesis that multiple myeloma cells express bone - related genes in a Runx2 - dependent fashion that mimics bone marrow resident cells and likely contributes to tumor survival and growth in the bone microenvironment,» Yang and colleagues wrote in the paper.

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

Wistar scientists have previously shown that age - related changes in the tumor microenvironment — or the surrounding area where tumor cells crosstalk with normal and immune cells — can drive melanoma progression and therapy resistance.

Down syndrome is caused by having three copies of chromosome 21 instead of two, and since four of the six interferon receptors — the proteins that sense the presence of interferons — are encoded on chromosome 21, cells with trisomy 21 react more strongly to small amounts of interferons in their microenvironment.

Studies in recent years by Beatty's laboratory and others have pointed to one potential source of this treatment resistance: Pancreatic tumors tend to surround themselves with a protective «microenvironment.»

The therapeutic use of stem cells is a promising area of medicine for the decades ahead and researchers are examining why stem cells function in certain types of niches, microenvironments, and pockets of activity.

«But in the body, within the microenvironment they create, they somehow manage to resist elimination even by our most cytotoxic therapies.»

The researchers analyzed the samples using immunohistochemistry and RNA sequencing to study the changes in the tumor immune microenvironment of patients who received and did not receive chemotherapy, and changes before and after chemotherapy.

«Dendritic cells are essential for prompting the immune response against malignant cells and for driving the clinical success of cancer immunotherapy, but their function is often defective in cancer patients,» said Dmitry I. Gabrilovich, M.D., Ph.D., Christopher M. Davis Professor and program leader of the Immunology, Microenvironment & Metastasis Program at Wistar.

In these leaves, Azolla have created a microenvironment, co-evolving with tiny bacteria called cyanobacteria for an estimated 100 million years.

«It shows that the egg is playing an active role in creating the microenvironment that it needs to continue its development,» says Dr. Clarke, lead study author, who is also a senior scientist from the Child Health and Human Development Program at the RI - MUHC and a professor and research director of the Department of Obstetrics and Gynecology at McGill University.

«Laminins function as attractive chemical cues for haptotaxis of axonal growth cones,» explains NAIST Prof. Naoyuki Inagaki, whose lab studies how forces are generated in the cellular microenvironment to create directed axonal migration.

Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.

The BSCB provides a specialized protective «microenvironment» for neural cells in the spinal cord.

However, tolerance - inducing mechanisms and the presence of suppressive cell types in the tumor microenvironment can dampen the response to immunotherapy.

«These findings suggest that BLBC cells have an innate ability to establish a local microenvironment that is supportive of cancer stem cells,» explained Thiagalingam, associate professor in Genetics & Genomics, Medicine, and Pathology & Laboratory Medicine, at BUSM.

In this rewriting of the textbooks, a tumor is not just a clump of aberrant cells; it also includes a support system, a tumor microenvironment, which encompasses a multitude of varying immune cell types and crisscrossing chemical signals, along with a network of blood vessels.

The researchers are now planning to address the impact of targeting autophagy either clinically and pharmacologically on the immune landscape of melanomas by phenotyping other immune cells in the melanoma tumor microenvironment.