Next, Mao and colleagues developed a way to study how genes and the tumor
microenvironment influence cancer development.
The cell influences its microenvironment and, at the same time,
the microenvironment influences cellular behavior — I am exploring this interrelationship.
Not exact matches
By better understanding the tumor
microenvironment we can develop strategies and treatment options to neutralize its oncogenic
influence and more effectively attack the tumor itself.
We decided to look at the exosomes of stromal cells, a type of cell that is commonly found in the tumor
microenvironment, and see if stromal exosomes were
influencing the energy consumption of cancer cells.»
Does nanotechnology offer unique opportunities to alter or
influence the tumor
microenvironment to suppress progression and invasion?
One limitation of our study is the use of metastatic samples from various organ sites, potentially
influencing expression via differences from the organ - specific tumor
microenvironment.
These may be driven by physiological
influences on the foraminiferal
microenvironment; a novel explanation is also suggested for the reduced δ11B - pH sensitivities observed in culture, based on variable calcification rates.
In light of these realizations, the long - term scientific goal of the program is to develop a detailed and mechanistic understanding of not just the tumor cell and tumor mutations, but also all the components of the host
microenvironment that
influence cancer and the response to cancer therapy.
The tumor
microenvironment, and in particular stroma organization,
influences the mode and dynamics of invasion.
«The notion that the stem cell
microenvironment is aging will certainly
influence how we think about using stem cells in regenerative medicine,» says Leanne Jones, Ph.D., an assistant professor in the Laboratory of Genetics who led the study.
Signaling Networks Controlling HCC Onset and Progression:
Influence of
Microenvironment and Implications for Cancer Gene Therapy