Sentences with phrase «microenvironment of»

These are «the microenvironment of marine plankton» and «the surface boundary layer of the ocean (gas exchange atmosphere - ocean)».

We're protecting our environment and improving the microenvironment of critters inside their cages.»

Second, they may act as desiccants, drying up the microenvironment of the flea larvae in the carpet, making it an unfavorable environment for survival.

A global analysis of the microenvironment of human skin fibroblasts was carried out to reveal disease ‐ related alterations in the extracellular proteome.

Dr. Jain's nominators note that, in sum, his work has provided ``... unprecedented molecular, cellular, anatomical and functional insights into the vascular pathophysiology of tumors, for proposing the seminal hypothesis that antiangiogenic therapy can «normalize» the aberrant vasculature and microenvironment of tumors and thereby improve both delivery and efficacy of treatment of solid tumors.»

The tunable physical and biological effects of selective targeting and activation of plasmonic nanobubbles (PNB) were studied in a heterogeneous biological microenvironment of prostate cancer and stromal cells.

Microscale flow devices have been developed in our lab that recreate the complex microenvironment of the circulation where inflammation and cancer metastasis occur.

The role of genetic alterations in the microenvironment of sporadic and heritable breast carcinomas and other solid tumors are being examined as they relate to clinical outcome.

The team then selected cells from these organoids and placed them inside the Intestine - Chips, which are about the size of AA batteries and re-create the natural microenvironment of the human intestine, including the intestinal epithelium — the layer of cells that forms the lining of both the small and large intestines.

Unravelling the Tumour - stroma Microenvironment of Late Stage Ovarian Cancer.

Spectral Shift of Fluorescent Dye FM4 - 64 Reveals Distinct Microenvironment of Nuclear Envelope in Living Cells.

Polysaccharide fraction of Agaricus brasiliensis avoids tumor - induced IL - 10 production and changes the microenvironment of subcutaneous Ehrlich adenocarcinoma.

3D bioengineered model of the tumor - stroma microenvironment of late stage ovarian cancer.

The remaining gaps between natural and bioengineered tissues may come from different developmental cues caused by the unique microenvironment of cells developing in a petri dish versus that of cells developing in a person or animal.

According to the study's results, the microenvironment of a tumor cell has significant impact on cancer metastasis.

The fact that FOX01 behaves in this unexpected way could have to do with the specialized microenvironment of a cell in a wound, Graves noted.

«Understanding the crosstalk between acinar cells with Kras mutations and the microenvironment of those cells is key to developing targeted strategies to prevent and treat this cancer,» he says.

«SynNotch receptors essentially allow us to confine the T cell response at the site of disease with the goal of enhancing the ability of the T cell to, for example, overcome the inhospitable microenvironment of a solid tumor.

But T cells typically can not attack tumors because the immunosuppressive microenvironment of tumors keeps APCs from turning these signals on.

«Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders.»

Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.

Together they are being used to peer into the microenvironment of tumors and other tissues while learning about the co-registration of multiple lines of imaging data.

The researchers analyzed the samples using immunohistochemistry and RNA sequencing to study the changes in the tumor immune microenvironment of patients who received and did not receive chemotherapy, and changes before and after chemotherapy.

In the future, this system will be further developed to reconstruct microenvironments of stem cells outside a living body, which would aid studies on stem cells for regenerative medicine.

Called «tumor microenvironments of metastasis,» these on - ramps are sites on blood vessels that special immune cells flock to.

Not exact matches

The starter culture changes the cheese microenvironment, affecting a variety of factors, including pH, redox potential, levels of organic acids such as lactate and acetate, and other nutrients.

«We need to better understand the complex sleep microenvironment to improve it and reduce the harmful effects of related pollutants on infants,» Corsi said.

The acceleration of the healing process occurs due to changes in the microenvironment in the wound, which change the behaviour of specific immune cells.

This quantitative, targeted, multiplexed approach leverages the power of next - generation sequencing and PCR technologies, and allows the researcher to obtain a molecular snapshot of the tumor microenvironment.

Changing the concentration of the enzyme's substrate molecule in the model produced an outcome that described how ATP synthase interacts with its microenvironment.

The study results builds on prior investigations by the research team which demonstrated that activation of the PI3K pathway by PTEN tumor loss created a «microenvironment» allowing tumors to evade immune suppression.

It's this «immunosuppressive» microenvironment that gives the remaining tumor cells license to metastasize and flourish in other parts of the body.

«However, many patients do not respond because myeloid derived suppressor cells (MDSCs), a type of inhibitory cell, are present in the tumour microenvironment.»

Changes in the ovarian microenvironment, such as reduced oxygen supply to the growing follicles are likely causes of ovarian aging, according to Patrizio.

«This technique creates a steady, sustained release of antibodies directly into the tumor site; it is an efficient approach with enhanced retention of anti-PD-1 antibodies in the tumor microenvironment,» says Zhen Gu, an assistant professor in the biomedical engineering program and senior author of the paper.

But following the removal of the primary tumor, micrometastatic cells learn to communicate with cells in their new microenvironment in the brain — cells which are, at first, hostile to them.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

University of Illinois researchers have developed a new technique to create a cell habitat of squishy fluids, called hydrogels, which can realistically and quickly recreate microenvironments found across biology.

Yet in a study led by Aimy Sebastian, a graduate student in the School of Natural Sciences at UC Merced who is conducting her Ph.D thesis work under Loots, identified the secreted bone protein Sclerostin (SOST), as a key molecule dysregulated as a result of prostate cancer - bone microenvironment interactions.

Kilian said his team's synthetic microenvironment lies somewhere in the middle of two extremes in the field of modeling biology: the hard plastic plate, and expensive mouse avatars that are created by injecting human tumor cells into mice.

Development of new therapies for the prevention and treatment of prostate cancer bone metastasis depends on understanding the dynamic reciprocal interactions between prostate cancer cells and the bone microenvironment.

Weeraratna's team used an artificial skin reconstruct model to recreate the interactions of melanoma cells with either a young or aged tumor microenvironment.

I think they may have been missing a piece of the puzzle, by not considering aging and the tumor microenvironment.»

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

Down syndrome is caused by having three copies of chromosome 21 instead of two, and since four of the six interferon receptors — the proteins that sense the presence of interferons — are encoded on chromosome 21, cells with trisomy 21 react more strongly to small amounts of interferons in their microenvironment.

Studies in recent years by Beatty's laboratory and others have pointed to one potential source of this treatment resistance: Pancreatic tumors tend to surround themselves with a protective «microenvironment.»

One team of researchers from Vanderbilt University aims to unlock how irradiation might alter the mechanical properties of the microenvironment.

The therapeutic use of stem cells is a promising area of medicine for the decades ahead and researchers are examining why stem cells function in certain types of niches, microenvironments, and pockets of activity.

To date, much of the research on irradiation's effects on the cellular microenvironment has dealt with samples that included cells, obfuscating the irradiation's effect on just the ECM rather than the cell's internal machinery.