Sentences with phrase «microenvironments for»

Marina Prewitz (Werner, LG)-- «Decellularised extracellular matrices as instructive microenvironments for bone marrow derived stem cells» (2011)

It suggests a new pathway to target in the microenvironment for cancer cells.»

The production of CSF - 1 by adipocytes may then create a permissive microenvironment for these monocytes to differentiate and survive as mature adipose tissue macrophages.

We are unraveling the mechanisms of this modulation in different solid and hematological malignancies and investigating ways to potentiate iNKT cell control of the tumor microenvironment for cancer immunotherapy.

Before he joined Moderna in 2013, Dr. Frederick was a Translational Research group leader at Aveo Oncology, focused on the generation of biomarkers for therapeutic response prediction, as well as avenues to modulate the tumor microenvironment for therapeutic benefit.

My specialty is on microRNA as expressed by the thymic microenvironment for the generation of regulatory T cells (Tregs) and how these molecular interactions establish central tolerance to promote protection from autoimmunity.

This result suggests that the peripheral region of EBs is a suitable microenvironment for germ cell differentiation.

Not exact matches

But until now, scientists have been hard - pressed to develop new therapies for treating IBDs due to their inability to replicate the human gut microenvironment in the laboratory.

Development of new therapies for the prevention and treatment of prostate cancer bone metastasis depends on understanding the dynamic reciprocal interactions between prostate cancer cells and the bone microenvironment.

The therapeutic use of stem cells is a promising area of medicine for the decades ahead and researchers are examining why stem cells function in certain types of niches, microenvironments, and pockets of activity.

«Dendritic cells are essential for prompting the immune response against malignant cells and for driving the clinical success of cancer immunotherapy, but their function is often defective in cancer patients,» said Dmitry I. Gabrilovich, M.D., Ph.D., Christopher M. Davis Professor and program leader of the Immunology, Microenvironment & Metastasis Program at Wistar.

In these leaves, Azolla have created a microenvironment, co-evolving with tiny bacteria called cyanobacteria for an estimated 100 million years.

«Laminins function as attractive chemical cues for haptotaxis of axonal growth cones,» explains NAIST Prof. Naoyuki Inagaki, whose lab studies how forces are generated in the cellular microenvironment to create directed axonal migration.

The BSCB provides a specialized protective «microenvironment» for neural cells in the spinal cord.

When looking for culprits, researchers have often focused their microscopes on macrophages, which occupy a meaningful spot among the white blood cells in the tumor microenvironment.

«Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders.»

The team has shown that the microenvironment that controls hematopoietic stem cells can be targeted for the treatment of a set of disorders called myeloproliferative neoplasias, the most prominent of which are chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and atypical chronic myelogenous leukemia (CML).

Protecting this microenvironment, or niche, has thus emerged as a new route for the treatment of these diseases, for which there is currently no fully effective treatment.

«SynNotch receptors essentially allow us to confine the T cell response at the site of disease with the goal of enhancing the ability of the T cell to, for example, overcome the inhospitable microenvironment of a solid tumor.

If there is a microenvironment that provides the context for activating cells that can spread cancer, then that's important to know.»

«I think that we've produced a 3 - D microenvironment which is much more like that found in vivo for growing embryoid body, which explains the higher levels of cell proliferation.»

«With Teresa Woodruff's research using Draper's human organ system platform, we have a compelling demonstration of the importance of a microenvironment that permits cells to function in vitro as they would in vivo, and the power of being able to interconnect organ models on a platform and operate them in a stable and precise manner for weeks to months,» said Jeffrey T. Borenstein, a biomedical engineer at Draper.

«Hypoxia can occur for many reasons, but in early FOP flare - ups, we speculated that hypoxia might result from the inflammatory microenvironment in lesions,» Kaplan said.

For efficiently studying cell functions, it is essential to reconstruct cellular microenvironments by parallel manipulation of single cells.

In the future, this system will be further developed to reconstruct microenvironments of stem cells outside a living body, which would aid studies on stem cells for regenerative medicine.

Timothy Wang at Columbia recently published work in Cancer Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel therapy.

As the small intestinal microenvironment can be maintained for weeks in continuously perfused Organ Chips, they enable both short and longer - term studies whose observations can be related back to the health and physiology of individual donors.

«Our research has identified the right soil for seeds to flourish by looking at the microenvironment in the breast and examining the mechanisms at play.

For about a decade, researchers have been able to direct the fate of stem cells by tuning the stiffness of its microenvironment.

«These results revealed for the first time that the TRIF pathway is involved in eliminating aberrantly activated astrocytes to maintain the microenvironment surrounding motor neurons in ALS mice,» Yamanaka says.

The team has been able to prove that such epigenetic alterations are associated with the increased levels of an enzyme, namely DNA methyltransferase 3A (DNMT3A), which is responsible for the acquisition of the suppressive properties of these cells that develop in the tumoral microenvironment.

The LOCI lab specializes in developing new imaging techniques for living things, with a special interest in studying cells in their microenvironment rather than in isolation.

In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of the osteoblastic or osteolytic phenotype.

For example, low grade inflammation in the tumour microenvironment can attract detrimental regulatory cells and neutrophils which can inhibit tumour immunity and promote tumorigenic factors.14

Michael Gershon, MD, Pathology & Cell Biology, will receive $ 2,193,710 over five years from the National Institute of Neurological Disorders and Stroke for «Microenvironment in Enteric Neuron Development» in a competitive renewal.

The Cancer Research Institute (CRI) iAtlas (www.cri-iatlas.org) is an interactive web - based platform and set of analytic tools for studying interactions between tumors and the immune microenvironment.

Requirement for IRF - 1 in the microenvironment supporting development of natural killer cells.

NEW YORK and SEATTLE — April 5, 2018 — The Cancer Research Institute (CRI), Institute for Systems Biology (ISB) and Sage Bionetworks — three organizations on the forefront of cancer immunotherapy, systems biology and bioinformatics — today announced the release of the Cancer Research Institute iAtlas, a comprehensive web - based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvironment.

Our findings show how the tumor microenvironment drives the acquisition of CD39 as an immune regulatory molecule on CD8 + T cells, with implications for defining a biomarker of T cell dysfunction and a target for immunotherapeutic intervention.

Nevertheless a role for these cells can not be excluded, it is possible that an incomplete replication of the suppressive microenvironment in vitro or indeed the diversity of Treg populations mean that these studies do not fully explore the potential role of suppressive or regulatory T cells in promoting MSC tolerance.

Matrix engineering: Decellularized or reconstituted biopolymer matrices and modular, biofunctional hydrogels are designed to create cell - instructive microenvironments and morphogenetic matrices for regenerative therapies.

For 2018, the CIMT program committee is preparing plenary sessions from pre-clinical research to clinical development on the topics of therapeutic vaccination, cellular therapy, improving immunity, tumor microenvironment, antibodies, regulatory research and immunoguiding.

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

Development and validation of a modular 3D microenvironment platform technology for studying prostate cancer - induced bone metastasis.

For instance, we previously demonstrated that DGKζ - deficient T cells demonstrate partial insensitivity to several important mediators of immune inhibition within the tumor microenvironment, including PGE2 (12), adenosine (12), TGF - β (13), and PD - L1 (10).

For understanding the biology of gene - gene, gene - drug and gene - microenvironment interactions, a considerably broader range of in vitro and in vivo model systems is required — we are generating 1,000 organoid cultures from human cancers, characterising their genomes, functional dependencies and drug response, and we are expanding our in vivo models to study the interface between cancer and the immune system and microenvironment.

Research in the Immunology, Microenvironment and Metastasis program is aimed at 1) merging basic mechanistic understanding of multidisciplinary pathways of host - tumor interactions and metastatic dissemination with novel translational opportunities for diseases diagnosis and immunotherapy, as well as 2) investigating mechanisms regulating immune responses in cancer and their potential therapeutic manipulation.

The company showed how they first defined A2A as the receptor required for mediating the effect of adenosine on immune cells within the tumor microenvironment and reported the characterization of a novel immuno - oncology - dedicated adenosine receptor 2A antagonist that functions in the high adenosine concentration found in tumors.

These results provide the validity to the newly developed hypoxia / reoxygenation culture system for examining the regulation of CSCs in breast cancer cell lines by niche factors in the tumor microenvironment and developing differential targeting strategies to eradicate breast CSCs.

Nanostructured and chemically functionalized materials which mimic architectural and mechanical features of natural cell microenvironments hold promise for a better understanding and control of cell physiological processes through molecular and nanoscale interactions.