Sentences with phrase «microenvironments known»
In conjunction with bone marrow tissue cells, these HSCs form a microenvironment known as a niche.
https://www.sciencedaily.com/ Not exact matches
If there is a microenvironment that provides the context for activating cells that can spread cancer, then that's important to know.»
Genetically modified «hunter» T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, Penn Medicine researchers report in a new study this week in Science Translational Medicine.
The problem with only tuning the stiffness of a cell's microenvironment, also known as the extracellular matrix, is that it assumes the environment behaves like an elastic material, like rubber.
Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.
They reside in a specialized microenvironment, known as a niche, that regulates their self - renewal and activities.
Nervous gut - the enteric nervous system, a so far unnoticed component of the tumor microenvironment, orchestrated by NDRG4 It is well - known that components of the tumor - microenvironment play an important role in the development of colorectal cancer.
His efforts have pioneered the use of the three - dimensional «artificial skin» cultures to study the behavior of both tumor and normal cells that sustain tumor growth, a system known as the tumor microenvironment.
Whether these defects are due to improper T cell activation by dysfunctional antigen presenting cells, suppression by the tumor microenvironment, or by improper homing of the «correct» T cells to the tumor is not known.
«We know that very few of the cells are becoming neurons, so we think that the stem cells are instead enhancing the local brain microenvironment,» Blurton - Jones said.