High content evaluation of shear dependent platelet function in
a microfluidic flow assay.
And a combination of
microfluidic flow and other micro-architectural features of the devices enables the cells inside organ chips to live and thrive in three dimensions, not two.
To prove their concept of this multiplex spectral microgel analysis within
a microfluidic flow, the team used «different barcodes corresponding to different emissions at specific wavelengths and the fluorescence intensity of known microRNA concentration,» which was measured for calibrations of the specific microRNA being explored.
With this algorithm,
microfluidic flows in multiple channels can be controlled in simultaneous and independent way.
Not exact matches
The basic definition of
microfluidics is «fluid
flow in a channel that has a dimension of less than one millimeter,» according to Ben Moga, president and cofounder of a company called Tasso Inc..
As bacteria stream through a
microfluidic lattice, they synchronize and swim in patterns similar to those of electrons
flowing through a magnetic material.
Developed by Assistant Professor Gretchen Mahler and Binghamton biomedical engineering alumna Courtney Sakolish PhD» 16, the reusable, multi-layered and
microfluidic device incorporates a porous growth substrate, with a physiological fluid
flow, and the passive filtration of the capillaries around the end of a kidney, called the glomerulus, where waste is filtered from blood.
With this method, they created a three - dimensional array of permeable carbon nanotubes within a
microfluidic device, through which fluid can
flow.
The research group integrated two externally - driven on - chip pumps into the
microfluidic chip for high - speed
flow control.
The sensor can detect the pressure difference inside and outside a
microfluidic channel, which could allow medical researchers to monitor how fast drugs
flow in the tubes.
«Faster, smaller, more informative: Device can measure the distribution of tiny particles as they
flow through a
microfluidic channel.»
Using
microfluidic design principles, Liu's group engineered vortices in their device to increase the chance that tumor cells will collide with the surface of the
flow channel.
«Microbiologists have rarely taken into account fluid
flow as an ecological parameter, whereas physicists have just recently started to pay attention to microbes,» he says, adding: «The ability to directly watch microbes under the controlled
flow conditions afforded by
microfluidic technology — which is only about 15 years old — has made all the difference in allowing us to discover and understand this effect of
flow on microbes.»
With the three - year grant, Vanapalli and his collaborators Boyd Butler in the Department of Biological Sciences and Everardo Cobos at the Texas Tech University Health Sciences Center, will build
microfluidic devices that mimic blood
flow to study how tumor cells move inside capillaries, how they squeeze through tight spaces, whether they are subject to fragmentation and how they become stuck.
The
microfluidic device is the size of a bento box and has a series of cables and pumps that cause media (simulated blood) to
flow between wells.
This illustration shows the
flow - focusing
microfluidic capillary device used to produce the silicone microcapsules.
The developed control algorithm can improve accuracy and stability of
flow regulation in a
microfluidic network without requiring any tuning process.
«Enhancing lab - on - a-chip peristalsis with electro - osmosis: Researchers have conducted analyses to electrically increase liquid
flow in pump - free
microfluidic devices.»
To study this barrier and determine why a lack of blood
flow causes it to leak, the researchers built a blood - vessel - on - a-chip model consisting of a channel lined with a layer of human endothelial cells surrounded by extracellular matrix within a
microfluidic device, which allowed them to easily simulate and control the
flow of blood through a vessel and evaluate the cells» responses.
They then used a simple
microfluidic layout to
flow the microgel and allow a continuous measurement of the fluorescence signal with several emission wavelengths for the multiplexed barcode detection.
In their article, the teams describe how they used the process to etch patterns of hollow channels like those used to direct the
flow of liquids, such as a blood sample, in a
microfluidic device, or lab on a chip.
A theoretical and experimental study of the electrophoretic extraction of ions from a pressure driven
flow in a
microfluidic device.
And most researchers working on this kind of chip were working with closed
microfluidic systems, which allow fluid to
flow in and out but do not offer an easy way to manipulate what is happening inside the chip.
The primary epithelial cells are expanded as 3D organoids, dissociated, and cultured on a porous membrane within a
microfluidic device with human intestinal microvascular endothelium cultured in a parallel microchannel under
flow and cyclic deformation.
He specializes in
microfluidic technology — the
flow of fluids through channels thinner than a human hair — to understand and control complex chemical and biological systems at critical times and locations.
The
microfluidic chip splits incoming
flow evenly into multiple smaller streams and hence enhances ionization efficiency significantly to achieve unprecedented robustness and sensitivity.
Here, we describe a
microfluidic device lined by living human kidney epithelial cells exposed to fluidic
flow that mimics key functions of the human kidney proximal tubule.