«Understanding the inflammatory process in the brain is critical if we are to develop better treatments not only for FTD, but for other forms of brain injury such as Parkinson's disease, Huntington's disease and multiple sclerosis (MS)-- which are likely also linked to abnormal
microglial activity.»
«Of course, it is not known when aging - associated changes in
microglial activities begin in the human brain, but these results in mice suggest that it may be earlier than we had previously appreciated,» Watters says.
Not exact matches
While it is known that microglia immune
activity changes with aging, which response is affected first — the pro-inflammatory or the anti-inflammatory — or, more importantly, when
microglial aging begins is not clear, says Jyoti Watters of the University of Wisconsin - Madison and lead investigator of the study.
A
microglial cell serves as a front - line sentry, monitoring its surroundings for suspicious
activities and materials by probing its local environment.