Sentences with word «micromolar»

With it, these sensors were sensitive enough to detect unlabeled cognate peptides both in organic solution and in the solid state at low micromolar concentrations.

Our data obtained with the MTT assay suggest a non-specific cytotoxic effect of long term (3 days) treatments of both endothelial and tumor cells with micromolar concentrations of kahweol.

Following purification, recombinant proteins were quantitated by ELISA and while expression levels varied significantly between individual proteins, most were purified to micromolar levels (Table 1).

«One compound (LJ001) looked really good, it had an IC50 of one micromolar [meaning that it inhibited the pathogen at a low concentration], which for an initial read is okay.

Chemotype Evolution has identified nanomolar inhibitors of kinases and protein - protein interactions starting from molecules with micromolar to millimolar potency.

By using the same relative cut - off level for both HbA1c and fructosamine (seven percent HbA1c correlated to 292 micromolar / liter of fructosamine) the researchers examined whether patients who tested above these thresholds had higher likelihood of complications.

She found that a high level of gamma - tocoperol, 10 micromolar in the blood plasma, was associated with a 10 to 17 percent reduction in lung function.

Although abundant in well - oxygenated environments, early skeletal animals did not occupy oxygen - impoverished regions of the shelf, demonstrating that oxygen availability (probably > 10 micromolar) was a key requirement for the development of early animal - based ecosystems.

The researchers demonstrated with in vitro and cell culture studies that sNOOOpy can monitor intracellular levels in the micromolar range of nitrate and nitrite in real time.

Taken together, these data suggest that indole derivatives, although their IC50 values are in the micromolar range, represent functional leads for further development of novel CXCR4 antagonists useful in medicinal chemistry programs.

Three iterations of Chemotype Evolution to transform a low - affinity molecule (Bait A, IC50 > 100 micromolar) into a potent drug lead.

In humans, serum levels of BHB are usually in the low micromolar range but begin to rise to a few hundred micromolar after 12 — 16 h of fasting, reaching 1 — 2 mM after 2 days of fasting (r) and 6 — 8 mM with prolonged starvation (r).