The app then recommends
microneedle patches to treat displayed skin issues.
At Emory, Compans has led research on ways to improve influenza vaccination, such as vaccines based on non-infectious virus - like particles and
microneedle patches for delivery (now being tested clinically).
Researchers have developed new
microneedle patches that can administer flu vaccines without the pain of using regular shots.
Painless, easy - to - use
microneedle patches could one day replace flu injections and help increase vaccination rates around the world, Science News reports.
Fluorescence imaging of
a microneedle patch.
«After 40 days, 40 percent of the mice who were treated using
the microneedle patch survived and had no detectable remaining melanoma — compared to a zero percent survival rate for the control groups,» says Yanqi Ye, a Ph.D. student in Gu's lab and co-lead author of the paper.
«
Microneedle patch delivers localized cancer immunotherapy to melanoma.»
Inventors holding
the microneedle patch in their hands (from left to right: David Chenloong Yeo, Chenjie Xu, Yuejun Kang, and Peng Xue).
In a trial of 100 people,
the microneedle patch caused no major side effects, little to no pain, and triggered an immune response similar to traditional flu shots, researchers report in The Lancet.
To expand their research on potential applications of
the microneedles patch, the NUS team conducted a study to explore its effectiveness in delivering collagen into skin.
Laboratory experiments showed that the novel
microneedles patch can deliver lidocaine within five minutes of application while a commercial lidocaine patch takes 45 minutes for the drug to penetrate into the skin.
As their novel technique for drug delivery is non-invasive and easy to use, the NUS team envisioned that
the microneedles patch has great potential for applications in clinical and home care settings for the management of perioperative pain and chronic pain in patients suffering from conditions like diabetes and cancer.
Dr Kang Lifeng of the Department of Pharmacy at NUS holding
a microneedle patch in his left hand, and a photomask in his right hand.
«Novel
microneedle patch for faster, effective delivery of painkiller, collagen.»
Not exact matches
These nanoparticles are then loaded into
microneedles, which are arrayed on the surface of a
patch.
When the
patch is applied to a melanoma, blood enters the
microneedles.
To address these challenges, the researchers developed a
patch that uses
microneedles to deliver anti-PD-1 antibodies locally to the skin tumor.
Self - administered by patients, the
microneedles attach the
patch to scar tissue and allow sustained drug - release (one
patch per night).
To address the clinical gap, Dr Kang, together with Dr Jaspreet Singh Kochhar, who had recently graduated from NUS with a doctorate degree in Pharmacy, and their team members, used a photolithography based process to fabricate a novel transdermal
patch with polymeric
microneedles.
The
patch also comprises a reservoir system to act as channels for drugs to be encapsulated in backing layers, circumventing the premature closure of miniaturised pores created by the
microneedles.
Here we report an innovative self - degradable
microneedle (MN)
patch for the sustained delivery of aPD1 in a physiologically controllable manner.
The
patch — which is little bigger than a penny — is covered with more than 100 «
microneedles» that sneak insulin nanoparticles into the body.