Analysis of polymorphic
microsatellites showed that the regions flanking COLQ are IBD, whereas those flanking the other 2 identified candidate genes are not.
Not exact matches
That's why a particular pattern of
microsatellites can profile a particular individual — to
show, for instance, as Tyler - Smith and Zerjal had done shortly before embarking on their Central Asian work, that Thomas Jefferson had fathered a son by his slave Sally Hemings and that his Y chromosome had been passed down to a man living in Pennsylvania today.
We have established two inbred lines that both
show a significant overall reduction in genetic diversity based on
microsatellite genotyping and genome - wide single nucleotide polymorphism (SNP).
SNP haplotypes spanning 3 genes were consistent with autosomal recessive transmission, and
microsatellite data
showed that only the segment encompassing COLQ was inherited IBD.
San Nicolas island foxes were found to be monomorphic at 18
microsatellite loci but
showed higher heterozygosity in MHC loci [17].
However, approximately 12 other loci
showed microsatellite variation that was obscured by bands from nonspecific amplifications.