The study, «Behavioral assessment of sensitivity to intracortical
microstimulation of primate somatosensory cortex,» was supported by the Defense Advanced Research Projects Agency Contract N66001 -10-C-4056.
We show that theta - burst
microstimulation of the right entorhinal area, applied prior to stimulus onset, enhanced memory specificity for these photographs.
Importantly, LTP induction by high - frequency
microstimulation of the perforant path in vivo has been shown to cause reorganization of wide hippocampal and cortical networks in rats (Canals et al., 2009).
Intracortical
microstimulation of the somatosensory cortex offers the potential for creating a sensory neuroprosthesis to restore tactile sensation.
Tactile percepts were consistently elicited in the hand of a person with cervical spinal cord injury using intracortical
microstimulation of the somatosensory cortex.
Not exact matches
While a robotic arm is controlled by neuronal activity recorded with optical imaging (red laser), the position
of the arm is fed back to the brain via optical
microstimulation (blue laser).
In conclusion, our findings suggest that
microstimulation, with its anatomical precision, physiologic - level currents, and action via axonal projections, holds promise for modification
of memory circuits and thus for the treatment
of memory impairments in people suffering from neurological disorders.
Future studies investigating how neural signals change in response to
microstimulation (and how these changes vary with the precise targeting
of the stimulating electrode) will be critical for increasing our understanding, not only
of the physiological signatures
of microstimulation, but also the microcircuit dynamics underlying memory.
As the use
of neural implants moves toward treating cognitive disorders, one advantage
of including
microstimulation is the precise spatial targeting it affords, allowing for highly - controlled manipulation
of neural circuits.
Future work examining the physiological effects
of microstimulation in downstream regions, such as the hippocampus, would further enlighten the mechanisms
of the differential effects when stimulation is applied in gray matter or the angular bundle.
Here, we asked whether application
of microstimulation targeted to the entorhinal afferents into hippocampus could enhance declarative memory function in humans.
Further research is needed to elucidate the mechanisms that shape the spatial - temporal firing patterns during saccades, and the behavior
of the SC population in more complex motor behaviors, like during head - free gaze shifts, curved double - step saccades, or electrical
microstimulation.