Research in my lab is directed at understanding the role of
the microtubule network in cell organization and function.
The hematopoietic stem cell polarization and migration: A dynamic link between RhoA signaling pathway,
microtubule network and ganglioside - based membrane microdomains.
Microtubule network is completely redesigned during muscle formation.
The research group working at IBMC focused on the exact moment of cell division, when cells assemble a new
microtubule network, which is then arranged as a very well - known structure: the mitotic spindle.
Not exact matches
Microtubules not only confer mechanical stability on cells and help to dictate their forms, they also serve as an intracellular transport
network.
«Zika virus infections cause a drastic perturbation of the cytoskeletal
network, re-organizing both intermediate filaments and
microtubules into a cage - like structure that surrounds the replication machinery.»
The researchers used their SDC - PAINT method to visualize the
network of cytoskeletal
microtubule filaments (green) and their proximity with two additional proteins called TOM20 (red) and HSP60 (blue).
«We know how motor proteins interact with
microtubules but how do you go from individual
microtubules and motor proteins to large
networked structures?»
Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have observed how
microtubules and motor proteins assemble into macroscopic
networks.
These stray chromosomes begin by attaching themselves to any
microtubule from the
network, which covers almost every nook and cranny, a bit like a
network of secondary roads of the mitotic spindle.
Every cell in our bodies contains a railway
network, a system of tiny tracks called
microtubules that run between important destinations inside the cell and allow cargo to be carried from one place to another, reports Professor Rob Cross, Professor of Mechanochemical Cell Biology at Warwick Medical School.
Professor Rob Cross, Professor of Mechanochemical Cell Biology at Warwick Medical School, said: «Every cell in our bodies contains a railway
network, a system of tiny tracks called
microtubules that run between important destinations inside the cell and allow cargo to be carried from one place to another.
From each of the centrosomes, a dense
network of
microtubules is assembled, reaching toward and around the mass of chromosomes.
Nuclei migrate through constricted spaces using
microtubule motors and actin
networks in C. elegans hypodermal cells.
Moreover, intact
microtubules and vimentin intermediate filament
networks are required for further growth.