Sentences with word «microvasculature»

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

The identification of dormant niches in basement membrane microvasculature and how those niches become metastatic in the neovasculature holds important implications for future breast cancer therapies.

With their organotypic models, Ghajar, Bissell and their collaborators discovered that the protein thrombospondin - 1, which is prevalent in stable microvasculature, creates a dormant niche by suppressing the growth of breast cancer cells.

A new study shows that stable microvasculature constitutes a dormant niche for disseminated breast cancer cells, whereas a sprouting neovasculature (green points) promotes breast tumor cell growth.

Moreover, this study will determine whether changes in retinal microvasculature can be used as a biomarker or clinical indicator for monitoring progression of glaucoma in clinical practice.

Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the microenvironment surrounding microvasculature — the small blood vessels that transport blood within tissues — as a niche where dormant cancer cells reside.

Megakaryocytes — some of which were derived from patients — were seeded into the engineered microvasculature.

Scanning electron micrograph of the coronary microvasculature of a mouse that has been treated with a small molecule tyrosine kinase inhibitor of platelet - derived growth factor receptor beta.

Chairs: Elena Aikawa, Brigham and Women's Hospital / Harvard Medical School and Anjelica Gonzalez, Yale University Christopher Hughes, University of California, Irvine Vascularized and perfused micro-tissues in culture and their use in drug screening Ying Zheng, University of Washington Engineering organ - specific microvasculature

Acquired tumor cell resistance to sunitinib causes resistance in a HT - 29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature

«Our study reveals that a stable microvasculature constitutes a dormant niche, whereas a sprouting neovasculature sparks micrometastatic outgrowth,» says cell biologist Mina Bissell, in whose laboratory this work was done.

Given that breast cancer cells traveling through the bloodstream on their way to secondary sites where breast tumors metastasize most often — lung, bone marrow, brain and liver — must first pass through the basement membrane microvasculature, Ghajar and Bissell suspected that the basement membrane could be a major component of the dormant niche in distant organs.

The tiny sensors, which consist of infrared light - emitting diodes (LEDs) coupled with a sensitive light detector, measure infinitesimal gradations in light in human tissue, due to changing blood volume in the microvasculature as blood circulates through the body — a process that follows in rhythm with the beating of the heart.

In order to mimic the production environment and microvasculature, the structures through which blood flows, the researchers formed silk sponges around porous silk microtubes.

And the work of Landon King, who is the director of the pulmonary and critical care medicine program at Johns Hopkins now; when Landon was a fellow in our laboratory, he discovered that in fact glucocorticoids, corticosteroids induce regulation expression of the aquaporins in the microvasculature of the lung.

Dr. Vivek Srinivasan: Work in my laboratory is attempting to build upon the results in Dr. Huberman's laboratory to use his finding of specific early changes in one layer of the retina in early glaucoma and to develop biomarkers for those changes based on the energy usage and microvasculature in that layer.

Yet, pericyte coverage in resting vessels varies widely in different organs and with type of microvasculature (continuous versus discontinuous versus fenestrated).

Improving our understanding of the relationship between changes in the retinal microvasculature, RNFL and lamina cribrosa in the pathophysiology of glaucoma can inform the development of new therapeutic targets designed to slow the microvasculature changes as a new non-IOP lowering approach to glaucoma therapy.

Type I interferon causes thrombotic microangiopathy by a dose - dependent toxic effect on the microvasculature.

Our goal is that Pro-Islet-1 can free both Type 1 and Type 2 diabetic patients from insulin dependence on a long term basis, while reducing or eliminating hypoglycemic, microvasculature and weight - mediated cardiovascular complications.

Life Extension Eye Pressure Support with Mirtogenol may support healthy blood flow within the tiny vessels (microvasculature) of your eyes, helping to promote healthy fluid pressure.

Cinnamon can also act as an agent that can increase circulation - which is highly beneficial to allow the immune system to reach the very small blood vessels (microvasculature) of the affected lung tissue.