Sentences with word «microvessel»

«This study demonstrates that microvessels in the brain play a key role in reacting to spikes in demand and accelerating the flow of blood to respond to neuronal activity.»
Fourteen - year disease - free survival falls to 69 percent for patients who have a high microvessel count combined with low nm23, but still have high or moderate E-cadherin levels.
(b) Quantification of microvessel density (MVD) in CD31 - stained tumours grown in WT and Tie2PEKO mice.
Only 44 percent of breast cancer patients with a high microvessel count, low nm23 and low E-cadherin levels are alive and disease free 14 years after surgery.
The researchers suggest it might be that the same things that damage blood vessels in the heart also damage microvessels elsewhere in the body.
Data are given as microvessel total count, and they are means ± S.D. of three different experiments.
B) Microvessel time course for the different treatments mentioned in A. Data are given as microvessel total count at different incubation times (spanning from 3 to to 10 days), and they are means ± S.D. of three different experiments.
The angiogenic response was quantified by microvessel counting according to published criteria [47].
These published studies showed that crude kuzu root preparations or their extracted flavonoids, given as injections or taken orally, Researchers also report that flavonoids lower cholesterol levels, reduce the risk of forming blood clots, protect the heart against cardiovascular disease, and protect the brain by dilating cerebral microvessels to increase blood flow.
Since cancer growth is associated with the formation of chaotic microvessels, the presence and location of cancer become visible.
Endothelial cells begin to branch off from preexisting microvessels and form capillary sprout structures that will ultimately coalesce and perfuse the tumor tissue.
Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.
(d) Quantification of retinal microvessel density (MVD) in P4, P6 and adult retinas of Tie2PEKO mice normalized to WT littermate average.
At intersections meeting within the foundational vascular grid, vertical vascular pillars are printed, which interconnect a pervasive network of microvessels throughout all dimensions of the stem cell - laden tissue.
Furthermore, a clear dose - response inhibition of microvessel formation was observed and quantified in treatments with kahweol.
In one of the membrane - facing channels, the researchers grow glomerular endothelial cells to mimic the blood microvessel compartment of glomeruli.
Transmission electron microscopy with colloidal gold immunocytochemistry showed structural damage in young and aged microvessel endothelium of ApoE4 animals extended to the cytoplasm of perivascular cells, perivascular nerve terminals and hippocampal neurons and glial cells.
E. coli K1 damages microvessels (green) that constitute the blood - brain barrier in an experimental newborn mouse model of meningitis.
The growth of new blood vessels tends to occur quite early for most cancers; even small tumors found via mammogram frequently have a high microvessel count (MVC).
(d) Quantification of microvessel density (MVD) in CD34 - stained plugs using HUVEC - BP shTie2 co-culture spheroids normalized to HUVEC - BP shCtr co-culture spheroids.
«The additional information we can now derive from tumor biomarkers such as E-cadherin, nm23 and microvessel counts should begin to allow us to tailor therapy according to individual tumor types,» added Samuel Hellman, MD, A.N. Pritzker Distinguished Service Professor of radiation and cellular oncology at the University of Chicago and co-author of the paper.
While arteries are the main supply routes into the brain, blood ultimately delivers its payload of oxygen to its final destination via a vast web of smaller capillaries — or microvessels — which permeate brain tissue.
The thin walls of the microvessels mean that the oxygen levels in adjacent brain tissue are mirrored within the capillaries, which can signal to red blood cells to spring into action.
These are cells typically tightly associated with brain microvessels, where they regulate induction and maintenance of the blood / brain barrier, and also control the diameter of the microvessels, thereby regulating local cerebral blood flow.
Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.
Since it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that influence cell behavior in microvessels and interstitial tissues, we make use of intravital microscopy.
Researchers found that while supplementing a high - fat diet with curcumin did not affect total caloric intake, it did reduce weight gain, adiposity, and microvessel density in adipose tissue.
It enhances the quality of the skin on the scalp and improves blood flow in microvessels.
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