Sentences with phrase «middle age mice»

Viruses were used to deliver Arc to middle age mice, after the critical window had closed.

The researchers tested their theory by orally administering a drug that inhibits DNA - PK and found that, in addition to preventing weight gain in the mice, the inhibitor drug boosted mitochondrial content in skeletal muscle, increased aerobic fitness in obese and middle aged mice, and reduced the incidence of obesity and type - 2 diabetes.

Not exact matches

Although stem cells in the hypothalamus create new neurons throughout life, the team noticed that mice start losing them in middle age — about 10 or 11 months old.

Normal mice saw benefits, too: Muscles and pancreas cells healed better in middle - aged mice that got rejuvenation treatments than in mice that did not.

Three groups of middle - aged mice (about a year old) were studied: one group ate a normal diet, in which fewer than 30 percent of calories came from fat, while two others were fed high - calorie diets in which 60 percent of the calories came from fat.

Most recently, they have taken mice in late middle age and lengthened the remainder of their lives by an average of 30 to 40 percent with a drug called rapamycin, an antifungal agent also used to suppress immune responses in transplant patients.

«But after 16 to 18 weeks — the mouse equivalent of early middle age — we noticed that the male mice born to moms with fragmented sleep were eating more.

Among the mice that received no THC, the middle - aged and elderly animals did far worse than the young ones.

To find out, his team gave young, middle - aged and elderly mice a steady but low dose of THC.

And in 2001, molecular biologist Mark Sands at Washington University in St. Louis, Missouri, found a high rate of liver tumors in middle - aged mice that had been treated as newborns with a supposedly safer viral vector.

Overexpressing a single gene called Arc rejuvenates the visual cortex of middle - age mice, making them as plastic as younger mice.

A year is considered middle aged for mice since their life expectancy is about two years.

To find out, the team gave young (2 - month - old), middle - aged (12 - month - old) and elderly (18 - month - old) mice a steady dose of THC.

In today's paper, the team reported what happened when the researchers turned on that killswitch in middle - aged mice, effectively scrubbing clean the mice of senescent cells.

Mice that had been eating a ketogenic diet performed at least as well on memory tests at old age as they did at middle age, while mice eating the normal diet showed an expected age - associated declMice that had been eating a ketogenic diet performed at least as well on memory tests at old age as they did at middle age, while mice eating the normal diet showed an expected age - associated declmice eating the normal diet showed an expected age - associated decline.

The researchers found that middle - aged mice displayed exaggerated pro-inflammatory responses after the first injection.

After initial testing demonstrated that their senoablative constructs could eliminate up to 80 % of senescent cells in cell culture, the Oisín team tested them out in living mice, showing that it can purge senescent cells from multiple tissues in middle - aged animals.

The research team at the University of Wisconsin - Madison studied the microglia activity of young (two months old) and middle - aged (nine to 10 months old) mice.

The study found that the microglia cells — the immune cells of the brain — in middle - aged mice already showed altered activity seen in microglia from older mice.

Another group of mice underwent memory testing at both middle age (one year old) and old age (two years old).

Even 9 - month - old mice (around middle age) improved after receiving the injections, suggesting that their brains could recuperate partially after half a lifetime of damage.

For context in mouse - years, 3 months is sort of like an older teen, and 9 months is about middle - aged.

To do that, he and his colleagues are studying 32 lines of genetically - defined young, middle - aged and old mice.

The professor at the University of Brescia Nisoli gave mice in their «middle age» water with the addition of amino acids that make up protein molecules.

In mice engineered to develop Alzheimer's - like symptoms, alternate - day fasting begun in middle age delayed the onset of memory problems by about six months.

By the time they were in late middle age, the mice that had not been given melatonin began to develop the behavioral changes and cognitive deficits seen in Alzheimer's disease.

Based on mouse studies conducted both at UW and elsewhere, they anticipate the drug «could increase healthy lifespan of middle - aged dogs by 2 - 5 years or more.»