«The present study fills a gap in the literature by showing the relationship between the fatty acid metabolism and
the migration of endothelial cells.»
MicroRNA - 24 inhibits the proliferation and
migration of endothelial cells in patients with atherosclerosis by targeting importin - a3 and regulating inflammatory responses.
It both promotes angiogenesis within the tumor and increased
the migration of endothelial cells, which form the inner lining of blood vessels.
Not exact matches
Like a free pass, its presence on the surface
of lymphoma
cells facilitates their
migration through the vessel walls between adjacent
endothelial cells.
Activation
of endothelial cells elicits a complex series
of responses that include the elaboration
of proteolytic enzymes,
migration, and proliferation.
MicroRNA - 195 regulates proliferation,
migration, angiogenesis and autophagy
of endothelial progenitor
cells by targeting GABARAPL1.
Release
of cytochrome c, Bax
migration, Bid cleavage, and activation
of caspases 2, 3, 6, 7, 8, and 9 during
endothelial cell apoptosis.
Expression
of angiopoietin - 1 in hypoxic pericytes: regulation by hypoxia - inducible factor - 2alpha and participation in
endothelial cell migration and tube formation.
Mechanotransduction The effects
of extracellular matrix stiffening on
endothelial cell health Cynthia Reinhart - King, Cornell University The effects
of membrane cholesterol and extracellular matrix elasticity on vascular smooth muscle
cell mechanics and
migration Zhongkui Hong, University
of South Dakota
Figure 6 shows the effects
of 75 µM kahweol on
endothelial cell migration, as determined by the «wound healing» assay, after 8 and 24 h
of treatment.
Researchers suspect that manipulation
of vascular
endothelial cell migration could be a useful therapeutic approach for those and other conditions.
They include its effects on
endothelial cell «differentiation» to yield tubular - like structures,
endothelial and tumor
cell proliferation, apoptosis, and
migration, as well as its effects on extracellular matrix remodelling enzyme activities
of matrix metalloproteinase - 2 (MMP - 2) and urokinase - type plasminogen activator (uPA).
We show for the first time that kahweol is an anti-angiogenic compound with inhibitory effects in two in vivo and one ex vivo angiogenesis models, with effects on specific steps
of the angiogenic process:
endothelial cell proliferation,
migration, invasion and tube formation on Matrigel.